"CK2" の関連情報検索結果

CK2 kinase–PRC2 signalling regulates genome-wide H3K27 trimethylation and transduces prolonged co...



CK2 kinase–PRC2 signalling regulates genome-wide H3K27 trimethylation and transduces prolonged cold exposure into epigenetic cold memory in plants  Nature

Discovery of a novel, selective CK2 inhibitor class with an unusual basic scaffold - ScienceDirec...



Discovery of a novel, selective CK2 inhibitor class with an unusual basic scaffold  ScienceDirect.com

Protein kinase CK2 sustains de novo fatty acid synthesis by regulating the expression of SCD-1 in...



Protein kinase CK2 sustains de novo fatty acid synthesis by regulating the expression of SCD-1 in human renal cancer cells  Cancer Cell International

Novel CK2 Inhibitor Silmitasertib Shows Promise in Advanced BCC - Targeted Oncology



Novel CK2 Inhibitor Silmitasertib Shows Promise in Advanced BCC  Targeted Oncology

Ellagic Acid and the Metabolite Urolithin A Suppress HSV-1 Infection and Brain Inflammation by Ta...



Ellagic Acid and the Metabolite Urolithin A Suppress HSV-1 Infection and Brain Inflammation by Targeting Casein Kinase CK2  ACS Publications

Picomolar bivalent inhibitors of protein kinase CK2 active against β-coronavirus replication - Sc...



Picomolar bivalent inhibitors of protein kinase CK2 active against β-coronavirus replication  ScienceDirect.com

Q&A: Turning THON fundraising into lifesaving medical treatments - Penn State Health News



Q&A: Turning THON fundraising into lifesaving medical treatments  Penn State Health News

Hinokiflavone is a novel CK2 inhibitor promoting apoptosis and synergizing with chemotherapeutic ...



Hinokiflavone is a novel CK2 inhibitor promoting apoptosis and synergizing with chemotherapeutic agents in cisplatin resistant bladder cancer cells  Nature

Discovery of 7,9-Dibromo-dihydrodibenzofuran as a Potent Casein Kinase 2 (CK2) Inhibitor: Synthes...



Discovery of 7,9-Dibromo-dihydrodibenzofuran as a Potent Casein Kinase 2 (CK2) Inhibitor: Synthesis, Biological Evaluation, and Structural Studies on E-/Z-Isomers  ACS Publications

Body weight control via protein kinase CK2: diet-induced obesity counteracted by pharmacological ...



Body weight control via protein kinase CK2: diet-induced obesity counteracted by pharmacological targeting  ScienceDirect.com

Correction: Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 wit...



Correction: Small molecule induces mitochondrial fusion for neuroprotection via targeting CK2 without affecting its conventional kinase activity | Signal Transduction and Targeted Therapy  Nature

Discovery of 7,9-Dibromo-dihydrodibenzofuran as a Potent Casein Kinase 2 (CK2) Inhibitor: Synthes...



Discovery of 7,9-Dibromo-dihydrodibenzofuran as a Potent Casein Kinase 2 (CK2) Inhibitor: Synthesis, Biological Evaluation, and Structural Studies on E-/Z-Isomers  ACS Publications

Targeting WDR5/ATAD2 signaling by the CK2/IKAROS axis demonstrates therapeutic efficacy in T-ALL ...



Targeting WDR5/ATAD2 signaling by the CK2/IKAROS axis demonstrates therapeutic efficacy in T-ALL  ScienceDirect.com

Missense mutation in the activation segment of the kinase CK2 models Okur-Chung neurodevelopmenta...



Missense mutation in the activation segment of the kinase CK2 models Okur-Chung neurodevelopmental disorder and alters the hippocampal glutamatergic synapse | Molecular Psychiatry  Nature

Scaffold hopping and sidechain modification from a flavone scaffold lead to discovery of potent, ...



Scaffold hopping and sidechain modification from a flavone scaffold lead to discovery of potent, selective CK2A2 inhibitors with favorable properties for CNS activity  ScienceDirect.com

Cold Atmospheric Plasma Jet Promotes Wound Healing Through CK2-Coordinated PI3K/AKT and MAPK Sign...



Cold Atmospheric Plasma Jet Promotes Wound Healing Through CK2-Coordinated PI3K/AKT and MAPK Signaling Pathways  ScienceDirect.com

MOTS-c modulates skeletal muscle function by directly binding and activating CK2 - ScienceDirect.com



MOTS-c modulates skeletal muscle function by directly binding and activating CK2  ScienceDirect.com

Phosphorylation-dependent charge blocks regulate the relaxation of nuclear speckle networks - Sci...



Phosphorylation-dependent charge blocks regulate the relaxation of nuclear speckle networks  ScienceDirect.com

CK2-dependent SK channel dysfunction as contributor to neuronal hyperexcitability in Alzheimer’s ...



CK2-dependent SK channel dysfunction as contributor to neuronal hyperexcitability in Alzheimer’s disease  ScienceDirect.com

Kirenol alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliora...



Kirenol alleviates cerebral ischemia-reperfusion injury by reducing oxidative stress and ameliorating mitochondrial dysfunction via activating the CK2/AKT pathway  ScienceDirect.com

Synthesis and evaluation of chemical linchpins for highly selective CK2α targeting - ScienceDirec...



Synthesis and evaluation of chemical linchpins for highly selective CK2α targeting  ScienceDirect.com

A comprehensive review on the dynamics of protein kinase CK2 in cancer development and optimizing...



A comprehensive review on the dynamics of protein kinase CK2 in cancer development and optimizing therapeutic strategies  ScienceDirect.com

(PDF) The protein kinase CK2 catalytic domain from Plasmodium falciparum: Crystal structure, tyro...



(PDF) The protein kinase CK2 catalytic domain from Plasmodium falciparum: Crystal structure, tyrosine kinase activity and inhibition  researchgate.net

Neuropilin-1-target self-assembled peptide nanoparticles contribute to tumor treatment by inducin...



Neuropilin-1-target self-assembled peptide nanoparticles contribute to tumor treatment by inducing pyroptosis  BMC Cancer

Casein kinase II (CK2) inhibitors - researchgate.net



Casein kinase II (CK2) inhibitors  researchgate.net

Mcam stabilizes a luminal progenitor-like breast cancer cell state via Ck2 control and Src/Akt/St...



Mcam stabilizes a luminal progenitor-like breast cancer cell state via Ck2 control and Src/Akt/Stat3 attenuation  Nature

LMP1, miRNA-BART-3p and CK2 regulate the PI3K/Akt signaling pathway.... - researchgate.net



LMP1, miRNA-BART-3p and CK2 regulate the PI3K/Akt signaling pathway....  researchgate.net

Targeting CK2 eliminates senescent cells and prolongs lifespan in Zmpste24 -deficient mice - Nature



Targeting CK2 eliminates senescent cells and prolongs lifespan in Zmpste24 -deficient mice  Nature

Figure 3. Identification of CK2 substrates using an... - researchgate.net



Figure 3. Identification of CK2 substrates using an...  researchgate.net

Protein Kinase CK2 in Cancer Energetics - Frontiers



Protein Kinase CK2 in Cancer Energetics  Frontiers

Figure 8: Involvement of Bcr-Abl and CK2 in MEK/ERK1/2 and... - researchgate.net



Figure 8: Involvement of Bcr-Abl and CK2 in MEK/ERK1/2 and...  researchgate.net

Targeting CK2 in cancer: a valuable strategy or a waste of time? - Nature



Targeting CK2 in cancer: a valuable strategy or a waste of time?  Nature

Therapeutic targeting of CK2 in acute and chronic leukemias - Nature



Therapeutic targeting of CK2 in acute and chronic leukemias  Nature

Inside the hellish design of the Crusader Kings video games - The Verge



Inside the hellish design of the Crusader Kings video games  The Verge

Protein kinase CK2: a potential therapeutic target for diverse human diseases - Nature



Protein kinase CK2: a potential therapeutic target for diverse human diseases  Nature

Figure 1: Involvement of protein kinase CK2 in blood tumor-associated... - researchgate.net



Figure 1: Involvement of protein kinase CK2 in blood tumor-associated...  researchgate.net

Figure 3. In vitro phosphorylation followed by LC-MS/MS demonstrates... - researchgate.net



Figure 3. In vitro phosphorylation followed by LC-MS/MS demonstrates...  researchgate.net

The ARK2N–CK2 complex initiates transcription-coupled repair through enhancing the interaction of...



The ARK2N–CK2 complex initiates transcription-coupled repair through enhancing the interaction of CSB with lesion-stalled RNAPII  PNAS

Inhibition of CK2 mitigates Alzheimer’s tau pathology by preventing NR2B synaptic mislocalization...



Inhibition of CK2 mitigates Alzheimer’s tau pathology by preventing NR2B synaptic mislocalization  Acta Neuropathologica Communications

CK2 phosphorylation of CMTR1 promotes RNA cap formation and influenza virus infection - ScienceDi...



CK2 phosphorylation of CMTR1 promotes RNA cap formation and influenza virus infection  ScienceDirect.com

Role of protein kinase CK2 in antitumor drug resistance - Journal of Experimental & Clinical Canc...



Role of protein kinase CK2 in antitumor drug resistance  Journal of Experimental & Clinical Cancer Research

Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the ...



Cancer selective cell death induction by a bivalent CK2 inhibitor targeting the ATP site and the allosteric αD pocket  ScienceDirect.com

Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors | Scientific R...



Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors | Scientific Reports  Nature

A CK2 and SUMO-dependent, PML NB-involved regulatory mechanism controlling BLM ubiquitination and...



A CK2 and SUMO-dependent, PML NB-involved regulatory mechanism controlling BLM ubiquitination and G-quadruplex resolution  Nature

Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem ce...



Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease  Nature

Chemically induced degradation of CK2 by proteolysis targeting chimeras based on a ubiquitin–prot...



Chemically induced degradation of CK2 by proteolysis targeting chimeras based on a ubiquitin–proteasome pathway  ScienceDirect.com

Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy - Science | AAAS



Phosphorylation of FAM134C by CK2 controls starvation-induced ER-phagy  Science | AAAS

Pharmacological inhibition of CK2 by silmitasertib mitigates sepsis-induced circulatory collapse,...



Pharmacological inhibition of CK2 by silmitasertib mitigates sepsis-induced circulatory collapse, thus improving septic outcomes in mice  ScienceDirect.com

Silmitasertib (CX-4945), a Clinically Used CK2-Kinase Inhibitor with Additional Effects on GSK3β ...



Silmitasertib (CX-4945), a Clinically Used CK2-Kinase Inhibitor with Additional Effects on GSK3β and DYRK1A Kinases: A Structural Perspective  ACS Publications

Calcineurin and CK2 Reciprocally Regulate Synaptic AMPA Receptor Phenotypes via α2δ-1 in Spinal E...



Calcineurin and CK2 Reciprocally Regulate Synaptic AMPA Receptor Phenotypes via α2δ-1 in Spinal Excitatory Neurons  Journal of Neuroscience

Copper Modulates the Catalytic Activity of Protein Kinase CK2 - Frontiers



Copper Modulates the Catalytic Activity of Protein Kinase CK2  Frontiers

CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregula...



CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in Huntington’s disease  Acta Neuropathologica Communications

CK2 phosphorylation of CCA1 is necessary for its circadian oscillator function in Arabidopsis - PNAS



CK2 phosphorylation of CCA1 is necessary for its circadian oscillator function in Arabidopsis  PNAS

CK2-mediated phosphorylation of SUZ12 promotes PRC2 function by stabilizing enzyme active site - ...



CK2-mediated phosphorylation of SUZ12 promotes PRC2 function by stabilizing enzyme active site  Nature

CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis - Na...



CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis  Nature

Dual Targeting Novel WDR5/ATAD2 Oncogenic Signaling through CK2/Ikaros Axis Demonstrates Synergis...



Dual Targeting Novel WDR5/ATAD2 Oncogenic Signaling through CK2/Ikaros Axis Demonstrates Synergistic Efficacy in T-ALL  ScienceDirect.com

Comparing the efficacy and selectivity of Ck2 inhibitors. A phosphoproteomics approach - ScienceD...



Comparing the efficacy and selectivity of Ck2 inhibitors. A phosphoproteomics approach  ScienceDirect.com

CK2 modulates adipocyte insulin-signaling and is up-regulated in human obesity - Nature



CK2 modulates adipocyte insulin-signaling and is up-regulated in human obesity  Nature

Mechanism of CK2 Inhibition by a Ruthenium-Based Polyoxometalate - Frontiers



Mechanism of CK2 Inhibition by a Ruthenium-Based Polyoxometalate  Frontiers

Au@CeO2 yolk-shell nanozymes restore mitochondrial dynamics and enhance chondrogenic drug respons...



Au@CeO2 yolk-shell nanozymes restore mitochondrial dynamics and enhance chondrogenic drug response for cartilage regeneration in osteoarthritis  ScienceDirect.com

Full article: CSNK2/CK2 regulates selective autophagy of the endoplasmic reticulum - Taylor & Fra...



Full article: CSNK2/CK2 regulates selective autophagy of the endoplasmic reticulum  Taylor & Francis Online

Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation - Nature



Tyrosine phosphorylation of histone H2A by CK2 regulates transcriptional elongation  Nature

CK2 and protein kinases of the CK1 superfamily as targets for neurodegenerative disorders - Front...



CK2 and protein kinases of the CK1 superfamily as targets for neurodegenerative disorders  Frontiers

Unexpected CK2β-antagonistic functionality of bisubstrate inhibitors targeting protein kinase CK2...



Unexpected CK2β-antagonistic functionality of bisubstrate inhibitors targeting protein kinase CK2  ScienceDirect.com

Development of a potent and selective chemical probe for the pleiotropic kinase CK2 - ScienceDire...



Development of a potent and selective chemical probe for the pleiotropic kinase CK2  ScienceDirect.com

Preclinical efficacy of CIGB-300, an anti-CK2 peptide, on breast cancer metastasic colonization -...



Preclinical efficacy of CIGB-300, an anti-CK2 peptide, on breast cancer metastasic colonization  Nature

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly - Nature



mTORC1 and CK2 coordinate ternary and eIF4F complex assembly  Nature

Evaluation of a Selective Chemical Probe Validates That CK2 Mediates Neuroinflammation in a Human...



Evaluation of a Selective Chemical Probe Validates That CK2 Mediates Neuroinflammation in a Human Induced Pluripotent Stem Cell-Derived Microglial Model  Frontiers

CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic m...



CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic massive vacuolization of colorectal cancer cells  Nature

ROS elevate HIF-1α phosphorylation for insect lifespan through the CK2-MKP3-p38 pathway - Science...



ROS elevate HIF-1α phosphorylation for insect lifespan through the CK2-MKP3-p38 pathway  ScienceDirect.com

Protein kinase CK2-dependent aerobic glycolysis-induced lactate dehydrogenase A enhances the migr...



Protein kinase CK2-dependent aerobic glycolysis-induced lactate dehydrogenase A enhances the migration and invasion of cancer cells  Nature

Structural basis for the design of bisubstrate inhibitors of protein kinase CK2 provided by compl...



Structural basis for the design of bisubstrate inhibitors of protein kinase CK2 provided by complex structures with the substrate-competitive inhibitor heparin  ScienceDirect.com

Association of protein kinase CK2 inhibition with cellular radiosensitivity of non-small cell lun...



Association of protein kinase CK2 inhibition with cellular radiosensitivity of non-small cell lung cancer  Nature

Figure 3. 3D binding mode of the four tested compounds with the ATP... - researchgate.net



Figure 3. 3D binding mode of the four tested compounds with the ATP...  researchgate.net

Comparing Two Neurodevelopmental Disorders Linked to CK2: Okur-Chung Neurodevelopmental Syndrome ...



Comparing Two Neurodevelopmental Disorders Linked to CK2: Okur-Chung Neurodevelopmental Syndrome and Poirier-Bienvenu Neurodevelopmental Syndrome—Two Sides of the Same Coin?  Frontiers

Targeting CK2-mediated phosphorylation of p53R2 sensitizes BRCA -proficient cancer cells to PARP ...



Targeting CK2-mediated phosphorylation of p53R2 sensitizes BRCA -proficient cancer cells to PARP inhibitors  Nature

The regulatory subunits of CK2 complex mediate DNA damage response and virulence in Candida Glabr...



The regulatory subunits of CK2 complex mediate DNA damage response and virulence in Candida Glabrata  BMC Microbiology

Crusader Kings 2 DLC – the complete guide - PCGamesN



Crusader Kings 2 DLC – the complete guide  PCGamesN

Protein kinase CK2 is necessary for the adipogenic differentiation of human mesenchymal stem cell...



Protein kinase CK2 is necessary for the adipogenic differentiation of human mesenchymal stem cells  ScienceDirect.com

Circumventing drug resistance through a CK2-targeted combination via attenuating endogenous AhR-T...



Circumventing drug resistance through a CK2-targeted combination via attenuating endogenous AhR-TLS-promoted genomic instability in human colorectal cancer cells  ScienceDirect.com

Myeloid Cell CK2 Regulates Inflammation and Resistance to Bacterial Infection - Frontiers



Myeloid Cell CK2 Regulates Inflammation and Resistance to Bacterial Infection  Frontiers

A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient ...



A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours  Nature

Regulation of DNA Methylation Patterns by CK2-Mediated Phosphorylation of Dnmt3a - ScienceDirect.com



Regulation of DNA Methylation Patterns by CK2-Mediated Phosphorylation of Dnmt3a  ScienceDirect.com

Transformative Tech – CK2 Technologies - Towne Post Network -



Transformative Tech – CK2 Technologies  Towne Post Network -

“Janus” efficacy of CX-5011: CK2 inhibition and methuosis induction by independent mechanisms - S...



“Janus” efficacy of CX-5011: CK2 inhibition and methuosis induction by independent mechanisms  ScienceDirect.com

Casein kinase 2 phosphorylates and induces the SALL2 tumor suppressor degradation in colon cancer...



Casein kinase 2 phosphorylates and induces the SALL2 tumor suppressor degradation in colon cancer cells  Nature

MRE11 stability is regulated by CK2-dependent interaction with R2TP complex - Nature



MRE11 stability is regulated by CK2-dependent interaction with R2TP complex  Nature

Blockade of chemo-resistance to 5-FU by a CK2-targeted combination via attenuating AhR-TLS-promot...



Blockade of chemo-resistance to 5-FU by a CK2-targeted combination via attenuating AhR-TLS-promoted genomic instability in human colon cancer cells  ScienceDirect.com

Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a...



Developmental phosphoproteomics identifies the kinase CK2 as a driver of Hedgehog signaling and a therapeutic target in medulloblastoma  Science | AAAS

IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymph...



IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia  ScienceDirect.com

Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Ene...



Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure  ScienceDirect.com

The best Crusader Kings 2 mods - PCGamesN



The best Crusader Kings 2 mods  PCGamesN

Inhibition of corticosterone synthesis impairs cued water maze consolidation, but it does not aff...



Inhibition of corticosterone synthesis impairs cued water maze consolidation, but it does not affect the expression of BDNF, CK2 and SGK1 genes in dorsal striatum  Frontiers

Small molecule modulators targeting protein kinase CK1 and CK2 - ScienceDirect.com



Small molecule modulators targeting protein kinase CK1 and CK2  ScienceDirect.com

Casein kinase 2 (CK2) increases survivin expression via enhanced β-catenin–T cell factor/lymphoid...



Casein kinase 2 (CK2) increases survivin expression via enhanced β-catenin–T cell factor/lymphoid enhancer binding factor-dependent transcription  PNAS

A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated M...



A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy  ScienceDirect.com

The upstream stimulatory factor USF1 is regulated by protein kinase CK2 phosphorylation - Science...



The upstream stimulatory factor USF1 is regulated by protein kinase CK2 phosphorylation  ScienceDirect.com

Protein Kinase CK2 represents a new target to boost Ibrutinib and Venetoclax induced cytotoxicity...



Protein Kinase CK2 represents a new target to boost Ibrutinib and Venetoclax induced cytotoxicity in mantle cell lymphoma  Frontiers

CK2 Phospho-Dependent Binding of R2TP Complex to TEL2 Is Essential for mTOR and SMG1 Stability - ...



CK2 Phospho-Dependent Binding of R2TP Complex to TEL2 Is Essential for mTOR and SMG1 Stability  ScienceDirect.com

Crusader Kings 2: The Old Gods Review - GameGrin



Crusader Kings 2: The Old Gods Review  GameGrin