Introducing the 'human repairome,' a catalog of DNA 'scars' that may help define personalized can...

Introducing the 'human repairome,' a catalog of DNA 'scars' that may help define personalized cancer treatments  Medical Xpress

Called the 'DREAM complex,' these proteins may determine how fast humans age - Earth.com

Called the 'DREAM complex,' these proteins may determine how fast humans age  Earth.com

“Human REPAIRome“ Catalogues 20,000 DNA Scar Patterns After Double-Stranded Breaks - Genetic Engi...

“Human REPAIRome“ Catalogues 20,000 DNA Scar Patterns After Double-Stranded Breaks  Genetic Engineering and Biotechnology News

DNA-repair pathway clears damaged gut cells and triggers tissue renewal after infection - Phys.org

DNA-repair pathway clears damaged gut cells and triggers tissue renewal after infection  Phys.org

CNIO Researchers Develop the “Human Repairome”: A Comprehensive - Bioengineer.org

CNIO Researchers Develop the “Human Repairome”: A Comprehensive  Bioengineer.org

RNF114, a RING E3 ligase that reads and extends the hybrid ADP-ribose-ubiquitin signal - EMBO Press

RNF114, a RING E3 ligase that reads and extends the hybrid ADP-ribose-ubiquitin signal  EMBO Press

Decoding the ubiquitin network: molecular mechanisms and therapeutic vulnerabilities for precisio...

Decoding the ubiquitin network: molecular mechanisms and therapeutic vulnerabilities for precision radio-sensitization in cancer  Molecular Cancer

HDAC6 as a Modulator of DNA Repair in Alzheimer’s Disease: From Mechanisms to Therapeutic Perspec...

HDAC6 as a Modulator of DNA Repair in Alzheimer’s Disease: From Mechanisms to Therapeutic Perspectives  ACS Publications

The interplay of DNA damage, epigenetics and tumour heterogeneity in driving cancer cell fitness ...

The interplay of DNA damage, epigenetics and tumour heterogeneity in driving cancer cell fitness  Nature

How fast you age may be controlled by a DNA repair boss in your cells - New Scientist

How fast you age may be controlled by a DNA repair boss in your cells  New Scientist

PALB2 and 53BP1 govern post-resection homologous recombination DNA repair - ScienceDirect.com

PALB2 and 53BP1 govern post-resection homologous recombination DNA repair  ScienceDirect.com

Cells Have a Second DNA Repair Toolbox for Difficult Cases - Tufts Now

Cells Have a Second DNA Repair Toolbox for Difficult Cases  Tufts Now

Hsa_circ_0038737 promotes PARPi resistance in castration-resistant prostate cancer via IGF2BP3-me...

Hsa_circ_0038737 promotes PARPi resistance in castration-resistant prostate cancer via IGF2BP3-mediated DNPH1 mRNA stabilization  Molecular Cancer

Pathogenic variants reveal candidate genes for prostate cancer germline testing for men of Africa...

Pathogenic variants reveal candidate genes for prostate cancer germline testing for men of African ancestry  Nature

DNA Damage, Epigenetics Fuel Tumor Diversity and Fitness - Bioengineer.org

DNA Damage, Epigenetics Fuel Tumor Diversity and Fitness  Bioengineer.org

Targeting DNA damage in ageing: towards supercharging DNA repair - Nature

Targeting DNA damage in ageing: towards supercharging DNA repair  Nature

POLD3 Knockdown Impacts Low-Grade Glioma - Bioengineer.org

POLD3 Knockdown Impacts Low-Grade Glioma  Bioengineer.org

Refined DNA repair manipulation enables a universal knock-in strategy in mouse embryos - Nature

Refined DNA repair manipulation enables a universal knock-in strategy in mouse embryos  Nature

The molecular basis of human transcription-coupled DNA repair - Nature

The molecular basis of human transcription-coupled DNA repair  Nature

Infrared and ultraviolet spectroscopic characterization of a key intermediate during DNA repair b...

Infrared and ultraviolet spectroscopic characterization of a key intermediate during DNA repair by (6-4) photolyase  Nature

FTO suppresses DNA repair by inhibiting PARP1 - Nature

FTO suppresses DNA repair by inhibiting PARP1  Nature

Protein droplets help protect genome during heterochromatin repair - USC Dornsife

Protein droplets help protect genome during heterochromatin repair  USC Dornsife

Histone H1 deamidation facilitates chromatin relaxation for DNA repair - Nature

Histone H1 deamidation facilitates chromatin relaxation for DNA repair  Nature

Suppressed DNA repair capacity in flight attendants after air travel - Scientific Reports - Nature

Suppressed DNA repair capacity in flight attendants after air travel - Scientific Reports  Nature

HR eye & MMR eye: one-day assessment of DNA repair-defective tumors eligible for targeted therapy...

HR eye & MMR eye: one-day assessment of DNA repair-defective tumors eligible for targeted therapy  Nature

βTrCP facilitates MRN complex localization on chromatin to enhance DNA repair | Communications Bi...

βTrCP facilitates MRN complex localization on chromatin to enhance DNA repair | Communications Biology  Nature

Mutant p53 confers chemoresistance by activating KMT5B-mediated DNA repair pathway in nasopharyng...

Mutant p53 confers chemoresistance by activating KMT5B-mediated DNA repair pathway in nasopharyngeal carcinoma  ScienceDirect.com

TopBP1 coordinates DNA repair synthesis in mitosis via recruitment of the nuclease scaffold SLX4 ...

TopBP1 coordinates DNA repair synthesis in mitosis via recruitment of the nuclease scaffold SLX4  Nature

SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair - ScienceDirect.com

SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair  ScienceDirect.com

Oncogenic properties of wild-type DNA repair gene FANCA in breast cancer - ScienceDirect.com

Oncogenic properties of wild-type DNA repair gene FANCA in breast cancer  ScienceDirect.com

The reverse transcriptase domain of prime editors contributes to DNA repair in mammalian cells - ...

The reverse transcriptase domain of prime editors contributes to DNA repair in mammalian cells  Nature

Teniposide Triggers DNA Repair Inhibition by Binding and Ubiquitination of Apurinic/Apyrimidinic ...

Teniposide Triggers DNA Repair Inhibition by Binding and Ubiquitination of Apurinic/Apyrimidinic Endonuclease 1 to Boost Oxidative DNA Damage for Lung Cancer Destruction  ACS Publications

DNA repair and disease: insights from the human DNA glycosylase NEIL family - Nature

DNA repair and disease: insights from the human DNA glycosylase NEIL family  Nature

Mystery solved: New study reveals how DNA repair genes play a major role in Huntington's disease ...

Mystery solved: New study reveals how DNA repair genes play a major role in Huntington's disease  UCLA Health

Cancer vulnerabilities exposed by finding interactions among DNA repair factors - Nature

Cancer vulnerabilities exposed by finding interactions among DNA repair factors  Nature

Robust prediction of synthetic gRNA activity and cryptic DNA repair by disentangling cellular CRI...

Robust prediction of synthetic gRNA activity and cryptic DNA repair by disentangling cellular CRISPR cleavage outcomes  Nature

Upregulation of POLE and proficient DNA repair are features of CIC DUX4 sarcomas - Nature

Upregulation of POLE and proficient DNA repair are features of CIC DUX4 sarcomas  Nature

Cell-cycle dependent DNA repair and replication unifies patterns of chromosome instability - Nature

Cell-cycle dependent DNA repair and replication unifies patterns of chromosome instability  Nature

Dynamics of DNA Repair by Class-II Photolyases via a Unified Electron-Transfer Bifurcating Mechan...

Dynamics of DNA Repair by Class-II Photolyases via a Unified Electron-Transfer Bifurcating Mechanism  ACS Publications

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senesc...

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells  Nature

Structural and molecular basis of PCNA-activated FAN1 nuclease function in DNA repair - Nature

Structural and molecular basis of PCNA-activated FAN1 nuclease function in DNA repair  Nature

RNA transcripts serve as a template for double-strand break repair in human cells - Nature

RNA transcripts serve as a template for double-strand break repair in human cells  Nature

How a crucial DNA repair protein works—and what it means for cancer treatment - Scripps Research

How a crucial DNA repair protein works—and what it means for cancer treatment  Scripps Research

MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistanc...

MS CETSA deep functional proteomics uncovers DNA repair programs leading to gemcitabine resistance  Nature

Function and inhibition of the DNA repair enzyme SNM1A - ScienceDirect.com

Function and inhibition of the DNA repair enzyme SNM1A  ScienceDirect.com

Inherited deficiency of DIAPH1 identifies a DNA double strand break repair pathway regulated by γ...

Inherited deficiency of DIAPH1 identifies a DNA double strand break repair pathway regulated by γ-actin  Nature

Virtual fragment screening for DNA repair inhibitors in vast chemical space - Nature

Virtual fragment screening for DNA repair inhibitors in vast chemical space  Nature

CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair - Nature

CHAMP1 complex directs heterochromatin assembly and promotes homology-directed DNA repair  Nature

Targeting Novel Molecular Mechanisms May Repair Damaged DNA - Northwestern University

Targeting Novel Molecular Mechanisms May Repair Damaged DNA  Northwestern University

NASA Provides Hardware for Space Station DNA Repair Experiment - NASA (.gov)

NASA Provides Hardware for Space Station DNA Repair Experiment  NASA (.gov)

D-2-hydroxyglutarate impairs DNA repair through epigenetic reprogramming - Nature

D-2-hydroxyglutarate impairs DNA repair through epigenetic reprogramming  Nature

The interplay of DNA repair context with target sequence predictably biases Cas9-generated mutati...

The interplay of DNA repair context with target sequence predictably biases Cas9-generated mutations  Nature

High protein intake causes gene-length-dependent transcriptional decline, shortens lifespan and a...

High protein intake causes gene-length-dependent transcriptional decline, shortens lifespan and accelerates ageing in progeroid DNA repair-deficient mice | npj Metabolic Health and Disease  Nature

Nuclear and genome dynamics underlying DNA double-strand break repair - Nature

Nuclear and genome dynamics underlying DNA double-strand break repair  Nature

A complete DNA repair system assembled by two endosymbionts restores heat tolerance of the insect...

A complete DNA repair system assembled by two endosymbionts restores heat tolerance of the insect host  PNAS

Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction - Nature

Endothelial-Ercc1 DNA repair deficiency provokes blood-brain barrier dysfunction  Nature

Distinct developmental outcomes in DNA repair-deficient FANCC c.67delG mutant and FANCC - Nature

Distinct developmental outcomes in DNA repair-deficient FANCC c.67delG mutant and FANCC  Nature

Changes in DNA repair compartments and cohesin loss promote DNA damage accumulation in aged oocyt...

Changes in DNA repair compartments and cohesin loss promote DNA damage accumulation in aged oocytes  ScienceDirect.com

Particulate hexavalent chromium inhibits global transcription of genes in DNA repair pathways, pa...

Particulate hexavalent chromium inhibits global transcription of genes in DNA repair pathways, particularly targeting homologous recombination repair, base excision repair, mismatch repair and microhomology-mediated end-joining  ScienceDirect.com

RIF1 integrates DNA repair and transcriptional requirements during the establishment of humoral i...

RIF1 integrates DNA repair and transcriptional requirements during the establishment of humoral immune responses  Nature

Genome-wide profiling of DNA repair proteins in single cells - Nature

Genome-wide profiling of DNA repair proteins in single cells  Nature

SART3 promotes homologous recombination repair by stimulating DNA-RNA hybrids removal and DNA end...

SART3 promotes homologous recombination repair by stimulating DNA-RNA hybrids removal and DNA end resection  Nature

ATAD5-BAZ1B interaction modulates PCNA ubiquitination during DNA repair - Nature

ATAD5-BAZ1B interaction modulates PCNA ubiquitination during DNA repair  Nature

A dual role of Cohesin in DNA DSB repair - Nature

A dual role of Cohesin in DNA DSB repair  Nature

RNA’s Surprising Role in DNA Repair - Georgia Tech News Center

RNA’s Surprising Role in DNA Repair  Georgia Tech News Center

DTX3L-mediated TIRR nuclear export and degradation regulates DNA repair pathway choice and PARP i...

DTX3L-mediated TIRR nuclear export and degradation regulates DNA repair pathway choice and PARP inhibitor sensitivity  Nature

Dynamics and mechanism of DNA repair by a bifunctional cryptochrome - PNAS

Dynamics and mechanism of DNA repair by a bifunctional cryptochrome  PNAS

Rapid DNA Repair in Mesenchymal Stem Cells and Bone Regeneration by Nanoparticle-Based Codelivery...

Rapid DNA Repair in Mesenchymal Stem Cells and Bone Regeneration by Nanoparticle-Based Codelivery of Nrf2-mRNA and Dexamethasone  ACS Publications

TET2 germline variants promote kidney disease by impairing DNA repair and activating cytosolic nu...

TET2 germline variants promote kidney disease by impairing DNA repair and activating cytosolic nucleotide sensors  Nature

Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime...

Large DNA deletions occur during DNA repair at 20-fold lower frequency for base editors and prime editors than for Cas9 nucleases  Nature

PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation - EMBO Press

PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation  EMBO Press

NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance - Nature

NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance  Nature

A NPAS4–NuA4 complex couples synaptic activity to DNA repair - Nature

A NPAS4–NuA4 complex couples synaptic activity to DNA repair  Nature

Cohesin regulates homology search during recombinational DNA repair - Nature

Cohesin regulates homology search during recombinational DNA repair  Nature

Parp1 promotes sleep, which enhances DNA repair in neurons - ScienceDirect.com

Parp1 promotes sleep, which enhances DNA repair in neurons  ScienceDirect.com

Crucial role and mechanism of transcription-coupled DNA repair in bacteria - Nature

Crucial role and mechanism of transcription-coupled DNA repair in bacteria  Nature

Ancient bacteria show evidence of DNA repair - PNAS

Ancient bacteria show evidence of DNA repair  PNAS

TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival - Scienc...

TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival  ScienceDirect.com

Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells - PNAS

Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells  PNAS

DNA damage-induced proteasome phosphorylation controls substrate recognition and facilitates DNA ...

DNA damage-induced proteasome phosphorylation controls substrate recognition and facilitates DNA repair  PNAS

Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1 - ScienceDirect.com

Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1  ScienceDirect.com

Mutagenesis and DNA Repair Regulation Group - National Institute of Environmental Health Sciences...

Mutagenesis and DNA Repair Regulation Group  National Institute of Environmental Health Sciences (.gov)

Structural basis of human transcription–DNA repair coupling - Nature

Structural basis of human transcription–DNA repair coupling  Nature

Visualizing the DNA repair process by a photolyase at atomic resolution - Science | AAAS

Visualizing the DNA repair process by a photolyase at atomic resolution  Science | AAAS

Action Heroes of DNA Repair - Harvard Medical School

Action Heroes of DNA Repair  Harvard Medical School

DNA repair during nonreductional meiosis in the asexual rotifer Adineta vaga - Science | AAAS

DNA repair during nonreductional meiosis in the asexual rotifer Adineta vaga  Science | AAAS

Msc1 is a nuclear envelope protein that reinforces DNA repair in late mitosis - ScienceDirect.com

Msc1 is a nuclear envelope protein that reinforces DNA repair in late mitosis  ScienceDirect.com

Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity - PNAS

Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity  PNAS

Monogenic Diseases of DNA Repair - The New England Journal of Medicine

Monogenic Diseases of DNA Repair  The New England Journal of Medicine

DNA double-strand break–capturing nuclear envelope tubules drive DNA repair - Nature

DNA double-strand break–capturing nuclear envelope tubules drive DNA repair  Nature

Recruitment of DNA methyltransferase I to DNA repair sites - PNAS

Recruitment of DNA methyltransferase I to DNA repair sites  PNAS

Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair - PNAS

Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair  PNAS

DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks - ScienceDirect.com

DNA Repair Profiling Reveals Nonrandom Outcomes at Cas9-Mediated Breaks  ScienceDirect.com

Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer - Nature

Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer  Nature

A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53...

A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers  ScienceDirect.com

DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Prot...

DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein  Science | AAAS

Enhancement of glycolysis-dependent DNA repair regulated by FOXO1 knockdown via PFKFB3 attenuates...

Enhancement of glycolysis-dependent DNA repair regulated by FOXO1 knockdown via PFKFB3 attenuates hyperglycemia-induced endothelial oxidative stress injury  ScienceDirect.com

Oncometabolites suppress DNA repair by disrupting local chromatin signalling - Nature

Oncometabolites suppress DNA repair by disrupting local chromatin signalling  Nature

Unveiling FRG1’s DNA repair role in breast cancer - Nature

Unveiling FRG1’s DNA repair role in breast cancer  Nature

When it comes to DNA repair, it’s not one tool fits all - UT Health San Antonio

When it comes to DNA repair, it’s not one tool fits all  UT Health San Antonio