"IL-2" の関連情報検索結果

Anti-inflammatory therapy with low-dose IL-2 in acute coronary syndromes: a randomized phase 2 tr...



Anti-inflammatory therapy with low-dose IL-2 in acute coronary syndromes: a randomized phase 2 trial  Nature

IL-2 and GLP-1 receptor agonist combination tackles neuroinflammation - Drug Target Review



IL-2 and GLP-1 receptor agonist combination tackles neuroinflammation  Drug Target Review

First-in-Class IL-2 Pathway Agonist Advances in AD - Dermatology Times



First-in-Class IL-2 Pathway Agonist Advances in AD  Dermatology Times

Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, dou...



Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial  The Lancet

FDA Clears IND Application for Novel IL-2 Agent in Advanced NSCLC - CancerNetwork



FDA Clears IND Application for Novel IL-2 Agent in Advanced NSCLC  CancerNetwork

IL-2 and IL-15 augment HBV therapeutic vaccination and PD1 blockade for functional cure in the AA...



IL-2 and IL-15 augment HBV therapeutic vaccination and PD1 blockade for functional cure in the AAV-HBV mouse model  Frontiers

Aulos looks to Phase III for IL-2 mAb in NSCLC and melanoma - Clinical Trials Arena



Aulos looks to Phase III for IL-2 mAb in NSCLC and melanoma  Clinical Trials Arena

Nektar says IL-2 pathway agonist rejected by Lilly succeeds in atopic dermatitis trial - FirstWor...



Nektar says IL-2 pathway agonist rejected by Lilly succeeds in atopic dermatitis trial  FirstWord Pharma

A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals - ...



A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals  Science | AAAS

[ESMO 2025] GI Innovation’s IL-2 therapy shows tumor response in ICB-resistant cancers - koreabio...



[ESMO 2025] GI Innovation’s IL-2 therapy shows tumor response in ICB-resistant cancers  koreabiomed.com

PD-1 + IL-2 power couple: Wake up 'sleepy' T cells to turbo-charge cancer cures - EurekAlert!



PD-1 + IL-2 power couple: Wake up 'sleepy' T cells to turbo-charge cancer cures  EurekAlert!

αTIGIT-IL2 achieves tumor regression by promoting tumor-infiltrating regulatory T cell fragility ...



αTIGIT-IL2 achieves tumor regression by promoting tumor-infiltrating regulatory T cell fragility in mouse models  Nature

Novel IL-2 Therapy Combo Yields Initial Responses in Nonsquamous NSCLC - CancerNetwork



Novel IL-2 Therapy Combo Yields Initial Responses in Nonsquamous NSCLC  CancerNetwork

In Silico tool for predicting, designing and scanning IL-2 inducing peptides | Scientific Reports...



In Silico tool for predicting, designing and scanning IL-2 inducing peptides | Scientific Reports  Nature

TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion | Nature Com...



TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion | Nature Communications  Nature

Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune respons...



Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune response  Nature

Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficac...



Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficacy in mouse autoimmune models  Nature

An immune competent in vitro model of IL2 induced vascular leakage enables mechanistic insights a...



An immune competent in vitro model of IL2 induced vascular leakage enables mechanistic insights and evaluation of mitigation strategies  Nature

An in situ engineered chimeric IL-2 receptor potentiates the tumoricidal activity of proinflammat...



An in situ engineered chimeric IL-2 receptor potentiates the tumoricidal activity of proinflammatory CAR macrophages in renal cell carcinoma  Nature

Biomineral tablets for long-acting IL-2 immunotherapy - Nature



Biomineral tablets for long-acting IL-2 immunotherapy  Nature

PD-1 x IL-2 antibody fusions: The next Keytruda competitors? - BioCentury



PD-1 x IL-2 antibody fusions: The next Keytruda competitors?  BioCentury

Low-dose interleukin-2 for recurrent early pregnancy loss: a proof-of-concept study - medRxiv



Low-dose interleukin-2 for recurrent early pregnancy loss: a proof-of-concept study  medRxiv

Mural risks going to the wall as IL-2 flop triggers 90% staff reduction, hunt for strategic alter...



Mural risks going to the wall as IL-2 flop triggers 90% staff reduction, hunt for strategic alternatives  Fierce Biotech

Anti-cancer effect of interleukin-2 fused to flagellin expressed by tumor-targeting Salmonella | ...



Anti-cancer effect of interleukin-2 fused to flagellin expressed by tumor-targeting Salmonella | Oncogene  Nature

Examining the evidence for IL-2 in amyotrophic lateral sclerosis - The Lancet



Examining the evidence for IL-2 in amyotrophic lateral sclerosis  The Lancet

Adding low-dose IL-2 to riluzole may improve survival in ALS - ALS News Today



Adding low-dose IL-2 to riluzole may improve survival in ALS  ALS News Today

Design of facilitated dissociation enables timing of cytokine signalling - Nature



Design of facilitated dissociation enables timing of cytokine signalling  Nature

A higher ratio of IL-2/IL-4 may be an early predictor of acute graft-versus-host disease after al...



A higher ratio of IL-2/IL-4 may be an early predictor of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation  Frontiers

Topline atopic dermatitis data showcase IL-2 modulator’s ‘incredibly novel’ mechanism - Healio



Topline atopic dermatitis data showcase IL-2 modulator’s ‘incredibly novel’ mechanism  Healio

FDA Clears IND for GL-IL2-138 in Cancer and Beyond - Targeted Oncology



FDA Clears IND for GL-IL2-138 in Cancer and Beyond  Targeted Oncology

Reshape the Fates of Treg and CD8+T Cells Through IL-2Rα by Synergizing Divergent Receptor-Biased...



Reshape the Fates of Treg and CD8+T Cells Through IL-2Rα by Synergizing Divergent Receptor-Biased IL-2 PEGylates  Wiley

9 biotechs making waves in interleukin therapeutics in 2025 - Labiotech.eu



9 biotechs making waves in interleukin therapeutics in 2025  Labiotech.eu

CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation | Nature Communic...



CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation | Nature Communications  Nature

Korea. IL-2 Series - Official Pre-Order Trailer - IGN



Korea. IL-2 Series - Official Pre-Order Trailer  IGN

Mural hits a wall | ApexOnco - Clinical Trials news and analysis - Oncology Pipeline



Mural hits a wall | ApexOnco - Clinical Trials news and analysis  Oncology Pipeline

Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 ove...



Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer  Nature

Low-dose interleukin-2 added to standard ALS treatment extends patient survival, clinical trial f...



Low-dose interleukin-2 added to standard ALS treatment extends patient survival, clinical trial finds  Medical Xpress

BLIMP1 negatively regulates IL-2 signaling in T cells - Science | AAAS



BLIMP1 negatively regulates IL-2 signaling in T cells  Science | AAAS

A glimpse into the application of the immunomodulatory effect of IL-2 in systemic lupus erythemat...



A glimpse into the application of the immunomodulatory effect of IL-2 in systemic lupus erythematosus  Frontiers

Interleukin-2 Inhibitors Clinical Trial Pipeline - GlobeNewswire



Interleukin-2 Inhibitors Clinical Trial Pipeline  GlobeNewswire

Coya Therapeutics Announces Results of Investigator-Initiated Study of LD IL-2 and CTLA4-Ig Demon...



Coya Therapeutics Announces Results of Investigator-Initiated Study of LD IL-2 and CTLA4-Ig Demonstrating Treg Enhancement and Cognitive Stability in Frontotemporal Dementia Patients  Business Wire

Coordinating interleukin-2 encoding circRNA with immunomodulatory lipid nanoparticles to potentia...



Coordinating interleukin-2 encoding circRNA with immunomodulatory lipid nanoparticles to potentiate cancer immunotherapy  Science | AAAS

France: budget approved, Lecornu survives censorship - Il Sole 24 ORE



France: budget approved, Lecornu survives censorship  Il Sole 24 ORE

Korea. IL-2 Series Releases New Gameplay Trailer - Bleeding Cool News



Korea. IL-2 Series Releases New Gameplay Trailer  Bleeding Cool News

New Flight Sim Wants You Broke To Get Above Minimum Spec - DualShockers



New Flight Sim Wants You Broke To Get Above Minimum Spec  DualShockers

National Air and Space Museum Completes Restoration of Ilyushin Il-2 Shturmovik - Vintage Aviatio...



National Air and Space Museum Completes Restoration of Ilyushin Il-2 Shturmovik  Vintage Aviation News

The Interleukin-2 Market is Set to Reach USD 4 Billion by 2034, Driven by IL-2 Targeting Fusion P...



The Interleukin-2 Market is Set to Reach USD 4 Billion by 2034, Driven by IL-2 Targeting Fusion Proteins, Monoclonal antibodies, and Gene Therapies Across Immunology, Dermatology, Neurodegenerative Disorders, and Oncology | DelveInsight  Yahoo Finance

Real-time visualization of STAT activation in live cells using genetically encoded biosensors - N...



Real-time visualization of STAT activation in live cells using genetically encoded biosensors  Nature

Flight sim "Korea. IL-2 series" developers dived to the ground and showed local residents - IXBT....



Flight sim "Korea. IL-2 series" developers dived to the ground and showed local residents  IXBT.games

IL-2 based cancer immunotherapies: an evolving paradigm - Frontiers



IL-2 based cancer immunotherapies: an evolving paradigm  Frontiers

Low-Dose Interleukin-2 Reduces Proinflammatory Biomarkers in Phase 2 Study of Alzheimer Disease -...



Low-Dose Interleukin-2 Reduces Proinflammatory Biomarkers in Phase 2 Study of Alzheimer Disease  NeurologyLive

Low-dose interleukin 2 therapy halts the progression of post-streptococcal autoimmune complicatio...



Low-dose interleukin 2 therapy halts the progression of post-streptococcal autoimmune complications in a rat model of rheumatic heart disease | mBio  ASM Journals

Effects of interleukin-2 in immunostimulation and immunosuppression - Rockefeller University Press



Effects of interleukin-2 in immunostimulation and immunosuppression  Rockefeller University Press

Basiliximab for IL‐2‐Associated Inflammatory Disorder With Atopic Dermatitis - Becker - 2025 - Pe...



Basiliximab for IL‐2‐Associated Inflammatory Disorder With Atopic Dermatitis - Becker - 2025 - Pediatric Dermatology  Wiley Online Library

Low-dose interleukin 2 therapy halts the progression of post-streptococcal autoimmune complicatio...



Low-dose interleukin 2 therapy halts the progression of post-streptococcal autoimmune complications in a rat model of rheumatic heart disease  ASM Journals

Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor ...



Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor  PNAS

PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function - Nature



PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function  Nature

Harnessing IL-2 for immunotherapy against cancer and chronic infection: a historical perspective ...



Harnessing IL-2 for immunotherapy against cancer and chronic infection: a historical perspective and emerging trends  Nature

Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells - Nature



Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells  Nature

Competition for IL-2 between Regulatory and Effector T Cells to Chisel Immune Responses - Frontiers



Competition for IL-2 between Regulatory and Effector T Cells to Chisel Immune Responses  Frontiers

Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and...



Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity  Nature

Engineering IL-2 for immunotherapy of autoimmunity and cancer - Nature



Engineering IL-2 for immunotherapy of autoimmunity and cancer  Nature

Dynamically modeling the effective range of IL-2 dosage in the treatment of systemic lupus erythe...



Dynamically modeling the effective range of IL-2 dosage in the treatment of systemic lupus erythematosus  ScienceDirect.com

IL-2 treatment can be dangerous. How can drug firms tackle its challenges? - Chemical & Engineeri...



IL-2 treatment can be dangerous. How can drug firms tackle its challenges?  Chemical & Engineering News

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program - Nature



PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program  Nature

Scientists Identify Key Biomarkers That May Predict Low-Dose IL-2 Treatment Efficacy in People wi...



Scientists Identify Key Biomarkers That May Predict Low-Dose IL-2 Treatment Efficacy in People with Systemic Lupus Erythematosus  Lupus Foundation of America

A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy -...



A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy  Nature

A single-agent fusion of human IL-2 and anti-IL-2 antibody that selectively expands regulatory T ...



A single-agent fusion of human IL-2 and anti-IL-2 antibody that selectively expands regulatory T cells  Nature

Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue...



Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue  Nature

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulator...



Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation  Nature

A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in...



A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia  Science | AAAS

Regulatory T-Cell Response to Low-Dose Interleukin-2 in Ischemic Heart Disease - NEJM Evidence



Regulatory T-Cell Response to Low-Dose Interleukin-2 in Ischemic Heart Disease  NEJM Evidence

An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism - Nature



An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism  Nature

A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8 - Nature



A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8  Nature

An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer - Nature



An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer  Nature

Regulatory T cells control toxicity in a humanized model of IL-2 therapy - Nature



Regulatory T cells control toxicity in a humanized model of IL-2 therapy  Nature

Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulatio...



Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity  Nature

Low-Dose IL-2 Therapy in Autoimmune and Rheumatic Diseases - Frontiers



Low-Dose IL-2 Therapy in Autoimmune and Rheumatic Diseases  Frontiers

Measurement of IFN-γ and IL-2 for the assessment of the cellular immunity against SARS-CoV-2 - Na...



Measurement of IFN-γ and IL-2 for the assessment of the cellular immunity against SARS-CoV-2  Nature

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes - Sci...



Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes  Science | AAAS

De novo design of potent and selective mimics of IL-2 and IL-15 - Nature



De novo design of potent and selective mimics of IL-2 and IL-15  Nature

IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8 - Nature



IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8  Nature

IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor ...



IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor | Nature Immunology  Nature

An engineered IL-2 partial agonist promotes CD8+ T cell stemness - Nature



An engineered IL-2 partial agonist promotes CD8+ T cell stemness  Nature

Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist...



Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist  Nature

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helpe...



Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells  Science | AAAS

Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung...



Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung allograft acceptance in mice  Nature

A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo ...



A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells  Nature

Restoring IL-2 to its cancer immunotherapy glory - Nature



Restoring IL-2 to its cancer immunotherapy glory  Nature

Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney tra...



Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney transplant recipients  Nature

The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity ...



The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity  Wiley Online Library

Molecular reshaping of phage-displayed Interleukin-2 at beta chain receptor interface to obtain p...



Molecular reshaping of phage-displayed Interleukin-2 at beta chain receptor interface to obtain potent super-agonists with improved developability profiles  Nature

Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of ...



Potent antitumour activity of interleukin-2-Fc fusion proteins requires Fc-mediated depletion of regulatory T-cells  Nature

WW2 Flight Sim Il-2 Sturmovik Announces Final Expansion Before New Korea Game - DualShockers



WW2 Flight Sim Il-2 Sturmovik Announces Final Expansion Before New Korea Game  DualShockers

T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes - Nature



T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes  Nature

Why measure soluble interleukin-2 receptor levels? - News-Medical



Why measure soluble interleukin-2 receptor levels?  News-Medical

Overcoming toxicities: are IL-2 smart cytokines the next big thing? - Labiotech.eu



Overcoming toxicities: are IL-2 smart cytokines the next big thing?  Labiotech.eu

A promising option for unremitting ulcerative colitis: Low-dose IL-2 - Boston Children's Answers



A promising option for unremitting ulcerative colitis: Low-dose IL-2  Boston Children's Answers

T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics - ...



T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics  Nature

Life-extended glycosylated IL-2 promotes Treg induction and suppression of autoimmunity - Nature



Life-extended glycosylated IL-2 promotes Treg induction and suppression of autoimmunity  Nature