Aulos looks to Phase III for IL-2 mAb in NSCLC and melanoma - Clinical Trials Arena

Aulos looks to Phase III for IL-2 mAb in NSCLC and melanoma  Clinical Trials Arena

Novel IL-2 Therapy Combo Yields Initial Responses in Nonsquamous NSCLC - CancerNetwork

Novel IL-2 Therapy Combo Yields Initial Responses in Nonsquamous NSCLC  CancerNetwork

In Silico tool for predicting, designing and scanning IL-2 inducing peptides | Scientific Reports...

In Silico tool for predicting, designing and scanning IL-2 inducing peptides | Scientific Reports  Nature

A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals - ...

A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals  Science | AAAS

Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, dou...

Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial  The Lancet

Medicenna Therapeutics Reports Second Quarter Fiscal 2026 Financial Results and Provides a Corpor...

Medicenna Therapeutics Reports Second Quarter Fiscal 2026 Financial Results and Provides a Corporate Update  GlobeNewswire

2 Babies Sickened In IL, Parents Warned Not To Use Recalled Baby Formula Amid Botulism Outbreak -...

2 Babies Sickened In IL, Parents Warned Not To Use Recalled Baby Formula Amid Botulism Outbreak  Patch

Nektar says IL-2 pathway agonist rejected by Lilly succeeds in atopic dermatitis trial - FirstWor...

Nektar says IL-2 pathway agonist rejected by Lilly succeeds in atopic dermatitis trial  FirstWord Pharma

Adding low-dose IL-2 to riluzole may improve survival in ALS - ALS News Today

Adding low-dose IL-2 to riluzole may improve survival in ALS  ALS News Today

Mural risks going to the wall as IL-2 flop triggers 90% staff reduction, hunt for strategic alter...

Mural risks going to the wall as IL-2 flop triggers 90% staff reduction, hunt for strategic alternatives  Fierce Biotech

Genetic Leap receives FDA IND clearance for first-in-class, oral natural IL-2 modulator - PR News...

Genetic Leap receives FDA IND clearance for first-in-class, oral natural IL-2 modulator  PR Newswire

PD-1 x IL-2 antibody fusions: The next Keytruda competitors? - BioCentury

PD-1 x IL-2 antibody fusions: The next Keytruda competitors?  BioCentury

IL-2 and IL-15 augment HBV therapeutic vaccination and PD1 blockade for functional cure in the AA...

IL-2 and IL-15 augment HBV therapeutic vaccination and PD1 blockade for functional cure in the AAV-HBV mouse model  Frontiers

[ESMO 2025] GI Innovation’s IL-2 therapy shows tumor response in ICB-resistant cancers - koreabio...

[ESMO 2025] GI Innovation’s IL-2 therapy shows tumor response in ICB-resistant cancers  koreabiomed.com

TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion | Nature Com...

TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion | Nature Communications  Nature

Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune respons...

Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune response  Nature

An in situ engineered chimeric IL-2 receptor potentiates the tumoricidal activity of proinflammat...

An in situ engineered chimeric IL-2 receptor potentiates the tumoricidal activity of proinflammatory CAR macrophages in renal cell carcinoma  Nature

Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficac...

Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficacy in mouse autoimmune models  Nature

Biomineral tablets for long-acting IL-2 immunotherapy - Nature

Biomineral tablets for long-acting IL-2 immunotherapy  Nature

CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation | Nature Communic...

CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation | Nature Communications  Nature

FDA Clears IND for GL-IL2-138 in Cancer and Beyond - Targeted Oncology

FDA Clears IND for GL-IL2-138 in Cancer and Beyond  Targeted Oncology

PD-1 + IL-2 power couple: Wake up 'sleepy' T cells to turbo-charge cancer cures - EurekAlert!

PD-1 + IL-2 power couple: Wake up 'sleepy' T cells to turbo-charge cancer cures  EurekAlert!

Coordinating interleukin-2 encoding circRNA with immunomodulatory lipid nanoparticles to potentia...

Coordinating interleukin-2 encoding circRNA with immunomodulatory lipid nanoparticles to potentiate cancer immunotherapy  Science | AAAS

Examining the evidence for IL-2 in amyotrophic lateral sclerosis - The Lancet

Examining the evidence for IL-2 in amyotrophic lateral sclerosis  The Lancet

Reshape the Fates of Treg and CD8+T Cells Through IL-2Rα by Synergizing Divergent Receptor-Biased...

Reshape the Fates of Treg and CD8+T Cells Through IL-2Rα by Synergizing Divergent Receptor-Biased IL-2 PEGylates  Wiley

Low-Dose Interleukin-2 Reduces Proinflammatory Biomarkers in Phase 2 Study of Alzheimer Disease -...

Low-Dose Interleukin-2 Reduces Proinflammatory Biomarkers in Phase 2 Study of Alzheimer Disease  Neurology Live

A glimpse into the application of the immunomodulatory effect of IL-2 in systemic lupus erythemat...

A glimpse into the application of the immunomodulatory effect of IL-2 in systemic lupus erythematosus  Frontiers

National Air and Space Museum Completes Restoration of Ilyushin Il-2 Shturmovik - Vintage Aviatio...

National Air and Space Museum Completes Restoration of Ilyushin Il-2 Shturmovik  Vintage Aviation News

Interleukin-2 Inhibitors Clinical Trial Pipeline Accelerates as 20+ Pharma Companies Rigorously D...

Interleukin-2 Inhibitors Clinical Trial Pipeline Accelerates as 20+ Pharma Companies Rigorously Develop Drugs for Market Entry | DelveInsight  GlobeNewswire

Low-dose interleukin-2 for recurrent early pregnancy loss: a proof-of-concept study - medRxiv

Low-dose interleukin-2 for recurrent early pregnancy loss: a proof-of-concept study  medRxiv

Nektar touts 'deepening clinical effect' of IL-2 agonist in atopic dermatitis - FirstWord Pharma

Nektar touts 'deepening clinical effect' of IL-2 agonist in atopic dermatitis  FirstWord Pharma

Topline atopic dermatitis data showcase IL-2 modulator’s ‘incredibly novel’ mechanism - Healio

Topline atopic dermatitis data showcase IL-2 modulator’s ‘incredibly novel’ mechanism  Healio

Based on the immune system: the role of the IL-2 family in pancreatic disease - Frontiers

Based on the immune system: the role of the IL-2 family in pancreatic disease  Frontiers

Low-dose interleukin-2 added to standard ALS treatment extends patient survival, clinical trial f...

Low-dose interleukin-2 added to standard ALS treatment extends patient survival, clinical trial finds  Medical Xpress

IL-15: from discovery to FDA approval - Journal of Hematology & Oncology

IL-15: from discovery to FDA approval  Journal of Hematology & Oncology

Cubs Place Catcher Miguel Amaya on the 10-day IL, 2 Days After Activating Him - FOX Sports

Cubs Place Catcher Miguel Amaya on the 10-day IL, 2 Days After Activating Him  FOX Sports

Low-dose interleukin 2 therapy halts the progression of post-streptococcal autoimmune complicatio...

Low-dose interleukin 2 therapy halts the progression of post-streptococcal autoimmune complications in a rat model of rheumatic heart disease | mBio  ASM Journals

WW2 Flight Sim Il-2 Sturmovik Announces Final Expansion Before New Korea Game - DualShockers

WW2 Flight Sim Il-2 Sturmovik Announces Final Expansion Before New Korea Game  DualShockers

Aulos Bioscience to Present Promising Phase 2 Data for Novel IL-2 Therapeutic AU-007 in Melanoma ...

Aulos Bioscience to Present Promising Phase 2 Data for Novel IL-2 Therapeutic AU-007 in Melanoma at AACR Annual Meeting  Yahoo Finance

Regulating IL-2 Immune Signaling Function Via A Core Allosteric Structural Network - ScienceDirec...

Regulating IL-2 Immune Signaling Function Via A Core Allosteric Structural Network  ScienceDirect.com

Teva and Fosun Pharma Enter into a Strategic Partnership to - GlobeNewswire

Teva and Fosun Pharma Enter into a Strategic Partnership to  GlobeNewswire

Engineered IL-2 molecule shows promise in treating autoimmune disease - healthenews.mcgill.ca

Engineered IL-2 molecule shows promise in treating autoimmune disease  healthenews.mcgill.ca

IL-2 based cancer immunotherapies: an evolving paradigm - Frontiers

IL-2 based cancer immunotherapies: an evolving paradigm  Frontiers

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothe...

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells  PNAS

Synthekine nabs $100M to boost IL-2 programs after rivals hit setbacks - Endpoints News

Synthekine nabs $100M to boost IL-2 programs after rivals hit setbacks  Endpoints News

Harnessing IL-2 for immunotherapy against cancer and chronic infection: a historical perspective ...

Harnessing IL-2 for immunotherapy against cancer and chronic infection: a historical perspective and emerging trends  Nature

PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function - Nature

PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function  Nature

Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor ...

Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor  PNAS

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program - Nature

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program  Nature

Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and...

Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity  Nature

Competition for IL-2 between Regulatory and Effector T Cells to Chisel Immune Responses - Frontiers

Competition for IL-2 between Regulatory and Effector T Cells to Chisel Immune Responses  Frontiers

Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells - Nature

Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells  Nature

A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy -...

A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy  Nature

Engineering IL-2 for immunotherapy of autoimmunity and cancer - Nature

Engineering IL-2 for immunotherapy of autoimmunity and cancer  Nature

A single-agent fusion of human IL-2 and anti-IL-2 antibody that selectively expands regulatory T ...

A single-agent fusion of human IL-2 and anti-IL-2 antibody that selectively expands regulatory T cells  Nature

CD8 cis-targeted IL-2 drives potent antiviral activity against hepatitis B virus - Science | AAAS

CD8 cis-targeted IL-2 drives potent antiviral activity against hepatitis B virus  Science | AAAS

An engineered IL-2 partial agonist promotes CD8+ T cell stemness - Nature

An engineered IL-2 partial agonist promotes CD8+ T cell stemness  Nature

De novo design of potent and selective mimics of IL-2 and IL-15 - Nature

De novo design of potent and selective mimics of IL-2 and IL-15  Nature

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulator...

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation  Nature

An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity...

An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice  Science | AAAS

Measurement of IFN-γ and IL-2 for the assessment of the cellular immunity against SARS-CoV-2 - Na...

Measurement of IFN-γ and IL-2 for the assessment of the cellular immunity against SARS-CoV-2  Nature

T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes - Nature

T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes  Nature

An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism - Nature

An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism  Nature

Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulatio...

Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity  Nature

A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in...

A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia  Science | AAAS

Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates ...

Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates dysfunctional CD8  Nature

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes - Sci...

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes  Science | AAAS

Molecular reshaping of phage-displayed Interleukin-2 at beta chain receptor interface to obtain p...

Molecular reshaping of phage-displayed Interleukin-2 at beta chain receptor interface to obtain potent super-agonists with improved developability profiles  Nature

Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue...

Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue  Nature

Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung...

Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung allograft acceptance in mice  Nature

A promising option for unremitting ulcerative colitis: Low-dose IL-2 - Boston Children's Answers

A promising option for unremitting ulcerative colitis: Low-dose IL-2  Boston Children's Answers

Scientists Identify Key Biomarkers That May Predict Low-Dose IL-2 Treatment Efficacy in People wi...

Scientists Identify Key Biomarkers That May Predict Low-Dose IL-2 Treatment Efficacy in People with Systemic Lupus Erythematosus  Lupus Foundation of America

Regulatory T cells control toxicity in a humanized model of IL-2 therapy - Nature

Regulatory T cells control toxicity in a humanized model of IL-2 therapy  Nature

A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8 - Nature

A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8  Nature

newsGP - Hope for simplifying coeliac disease diagnosis - RACGP

newsGP - Hope for simplifying coeliac disease diagnosis  RACGP

Dynamically modeling the effective range of IL-2 dosage in the treatment of systemic lupus erythe...

Dynamically modeling the effective range of IL-2 dosage in the treatment of systemic lupus erythematosus  ScienceDirect.com

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helpe...

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells  Science | AAAS

Low-Dose IL-2 Therapy in Autoimmune and Rheumatic Diseases - Frontiers

Low-Dose IL-2 Therapy in Autoimmune and Rheumatic Diseases  Frontiers

BCANTT 2024: Rationally Engineered IL2 for Enhanced Treatment of Local and Metastatic Bladder Can...

BCANTT 2024: Rationally Engineered IL2 for Enhanced Treatment of Local and Metastatic Bladder Cancer  UroToday

Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney tra...

Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney transplant recipients  Nature

IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor ...

IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor | Nature Immunology  Nature

An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer - Nature

An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer  Nature

A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo ...

A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells  Nature

A novel human IL-2 mutein with minimal systemic toxicity exerts greater antitumor efficacy than w...

A novel human IL-2 mutein with minimal systemic toxicity exerts greater antitumor efficacy than wild-type IL-2  Nature

Managing Toxicities of High-Dose Interleukin-2 - CancerNetwork

Managing Toxicities of High-Dose Interleukin-2  CancerNetwork

A CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organism - Nature

A CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organism  Nature

Efficacy and antitumor activity of a mutant type of interleukin 2 - Nature

Efficacy and antitumor activity of a mutant type of interleukin 2  Nature

Restoring IL-2 to its cancer immunotherapy glory - Nature

Restoring IL-2 to its cancer immunotherapy glory  Nature

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism - N...

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism  Nature

IL-2 Signaling Axis Defects: How Many Faces? - Frontiers

IL-2 Signaling Axis Defects: How Many Faces?  Frontiers

T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics - ...

T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics  Nature

T cell antitumor immunity by targeting IL-2 receptor signaling - Nature

T cell antitumor immunity by targeting IL-2 receptor signaling  Nature

Why measure soluble interleukin-2 receptor levels? - News-Medical

Why measure soluble interleukin-2 receptor levels?  News-Medical

T cell receptor and IL-2 signaling strength control memory CD8 - Nature

T cell receptor and IL-2 signaling strength control memory CD8  Nature

Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist...

Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist  Nature

Overcoming toxicities: are IL-2 smart cytokines the next big thing? - Labiotech.eu

Overcoming toxicities: are IL-2 smart cytokines the next big thing?  Labiotech.eu

PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells - Nature

PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells  Nature

Spatial microniches of IL-2 combine with IL-10 to drive lung migratory T - Nature

Spatial microniches of IL-2 combine with IL-10 to drive lung migratory T  Nature

Life-extended glycosylated IL-2 promotes Treg induction and suppression of autoimmunity - Nature

Life-extended glycosylated IL-2 promotes Treg induction and suppression of autoimmunity  Nature

An essential role for the IL-2 receptor in T - Nature

An essential role for the IL-2 receptor in T  Nature