Coupling IL-2 with IL-10 to mitigate toxicity and enhance antitumor immunity - ScienceDirect.com

Coupling IL-2 with IL-10 to mitigate toxicity and enhance antitumor immunity  ScienceDirect.com

TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion | Nature Com...

TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion | Nature Communications  Nature

Coya Therapeutics Announces Completion of Patient Enrollment of an Investigator-Initiated, Open-L...

Coya Therapeutics Announces Completion of Patient Enrollment of an Investigator-Initiated, Open-Label Study with Low-Dose IL-2 and CTLA4-Ig Combination Treatment in Patients with Mild to Moderate Frontotemporal Dementia  PR Newswire

A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals - ...

A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals  Science | AAAS

Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, dou...

Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial  The Lancet

Nektar says IL-2 pathway agonist rejected by Lilly succeeds in atopic dermatitis trial - FirstWor...

Nektar says IL-2 pathway agonist rejected by Lilly succeeds in atopic dermatitis trial  FirstWord Pharma

Synergistic potential of PD-1 blockade and IL-2 in cancer therapy via targeted bi-functional mole...

Synergistic potential of PD-1 blockade and IL-2 in cancer therapy via targeted bi-functional molecule design  ScienceDirect.com

Low-dose interleukin-2 induces clonal expansion of BACH2-repressed effector regulatory T cells fo...

Low-dose interleukin-2 induces clonal expansion of BACH2-repressed effector regulatory T cells following acute coronary syndrome  Nature

In Silico tool for predicting, designing and scanning IL-2 inducing peptides | Scientific Reports...

In Silico tool for predicting, designing and scanning IL-2 inducing peptides | Scientific Reports  Nature

Interleukin-2 and its receptors: Implications and therapeutic prospects in immune-mediated disord...

Interleukin-2 and its receptors: Implications and therapeutic prospects in immune-mediated disorders of central nervous system  ScienceDirect.com

An in situ engineered chimeric IL-2 receptor potentiates the tumoricidal activity of proinflammat...

An in situ engineered chimeric IL-2 receptor potentiates the tumoricidal activity of proinflammatory CAR macrophages in renal cell carcinoma  Nature

Directed disruption of IL2 aggregation and receptor binding sites produces designer biologics wit...

Directed disruption of IL2 aggregation and receptor binding sites produces designer biologics with enhanced specificity and improved production capacity  ScienceDirect.com

Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune respons...

Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune response  Nature

Dual IL-2/IL-21 priming augments the anti-tumor function of CD16V-CAR/TRAIL-engineered NK cells i...

Dual IL-2/IL-21 priming augments the anti-tumor function of CD16V-CAR/TRAIL-engineered NK cells in combination with monoclonal antibodies  ScienceDirect.com

Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficac...

Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficacy in mouse autoimmune models  Nature

IL-2 immunotherapy rescues irradiation-induced T cell exhaustion in mouse colon cancer - ScienceD...

IL-2 immunotherapy rescues irradiation-induced T cell exhaustion in mouse colon cancer  ScienceDirect.com

Regulatory T cell therapy promotes TGF-β and IL-6-dependent pro-inflammatory Th17 cell generation...

Regulatory T cell therapy promotes TGF-β and IL-6-dependent pro-inflammatory Th17 cell generation by reducing IL-2  Nature

Antibody durability is influenced by interleukin-2 production by undifferentiated memory T helper...

Antibody durability is influenced by interleukin-2 production by undifferentiated memory T helper cells and extensive B cell clonal expansion  ScienceDirect.com

Biomineral tablets for long-acting IL-2 immunotherapy - Nature

Biomineral tablets for long-acting IL-2 immunotherapy  Nature

CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation | Nature Communic...

CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation | Nature Communications  Nature

First-in-human evaluation of a no-alpha interleukin–2 mutein: safety and preliminary pharmacodyna...

First-in-human evaluation of a no-alpha interleukin–2 mutein: safety and preliminary pharmacodynamic and clinical effect  Frontiers

Coordinating interleukin-2 encoding circRNA with immunomodulatory lipid nanoparticles to potentia...

Coordinating interleukin-2 encoding circRNA with immunomodulatory lipid nanoparticles to potentiate cancer immunotherapy  Science | AAAS

Promising Dementia Treatment Trial: Coya Therapeutics Completes Key FTD Study Enrollment with Zer...

Promising Dementia Treatment Trial: Coya Therapeutics Completes Key FTD Study Enrollment with Zero Safety Issues  Stock Titan

Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 ove...

Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer  Nature

Anti-cancer effect of interleukin-2 fused to flagellin expressed by tumor-targeting Salmonella - ...

Anti-cancer effect of interleukin-2 fused to flagellin expressed by tumor-targeting Salmonella  Nature

An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to...

An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to promote T cell anergy  ScienceDirect.com

Examining the evidence for IL-2 in amyotrophic lateral sclerosis - The Lancet

Examining the evidence for IL-2 in amyotrophic lateral sclerosis  The Lancet

Interleukin-2-secreting T helper cells promote extra-follicular B cell maturation via intrinsic r...

Interleukin-2-secreting T helper cells promote extra-follicular B cell maturation via intrinsic regulation of a B cell mTOR-AKT-Blimp-1 axis  ScienceDirect.com

Based on the immune system: the role of the IL-2 family in pancreatic disease - Frontiers

Based on the immune system: the role of the IL-2 family in pancreatic disease  Frontiers

Regulating IL-2 Immune Signaling Function Via A Core Allosteric Structural Network - ScienceDirec...

Regulating IL-2 Immune Signaling Function Via A Core Allosteric Structural Network  ScienceDirect.com

A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-media...

A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies  ScienceDirect.com

Human serum albumin promotes interactions between HSA-IL-2 fusion protein and CD122 for enhancing...

Human serum albumin promotes interactions between HSA-IL-2 fusion protein and CD122 for enhancing immunotherapy  ScienceDirect.com

WW2 Flight Sim Il-2 Sturmovik Announces Final Expansion Before New Korea Game - DualShockers

WW2 Flight Sim Il-2 Sturmovik Announces Final Expansion Before New Korea Game  DualShockers

Novel [18F]FPG-interleukin-2 conjugate for monitoring immune checkpoint therapy with positron emi...

Novel [18F]FPG-interleukin-2 conjugate for monitoring immune checkpoint therapy with positron emission tomography  ScienceDirect.com

IL-2/anti-IL-2 antibody complexes augment immune responses to therapeutic cancer vaccines - PNAS

IL-2/anti-IL-2 antibody complexes augment immune responses to therapeutic cancer vaccines  PNAS

Antibody-based delivery of interleukin-2 modulates the immunosuppressive tumor microenvironment a...

Antibody-based delivery of interleukin-2 modulates the immunosuppressive tumor microenvironment and achieves cure in pancreatic ductal adenocarcinoma syngeneic mice  Journal of Experimental & Clinical Cancer Research

Early Serum IL-2 Levels Are Associated With CAR T-Cell Expansion Post–CAR T-Cell Therapy - OncLive

Early Serum IL-2 Levels Are Associated With CAR T-Cell Expansion Post–CAR T-Cell Therapy  OncLive

Predictive biomarkers for low-dose IL-2 therapy efficacy in systemic lupus erythematosus: a clini...

Predictive biomarkers for low-dose IL-2 therapy efficacy in systemic lupus erythematosus: a clinical analysis  Arthritis Research & Therapy

Scientists Identify Key Biomarkers That May Predict Low-Dose IL-2 Treatment Efficacy in People wi...

Scientists Identify Key Biomarkers That May Predict Low-Dose IL-2 Treatment Efficacy in People with Systemic Lupus Erythematosus  Lupus Foundation of America

Novel design of potent anti-tumour activity of IL-2 prodrug by FAPα-mediated activation - Science...

Novel design of potent anti-tumour activity of IL-2 prodrug by FAPα-mediated activation  ScienceDirect.com

Targeting systemic IL-2 to BCMA CAR-T cells - Nature

Targeting systemic IL-2 to BCMA CAR-T cells  Nature

Interleukin-2 improves insulin sensitivity through hypothalamic sympathetic activation in obese m...

Interleukin-2 improves insulin sensitivity through hypothalamic sympathetic activation in obese mice  Journal of Neuroinflammation

Spatial microniches of IL-2 combine with IL-10 to drive lung migratory T - Nature

Spatial microniches of IL-2 combine with IL-10 to drive lung migratory T  Nature

IL-2 based cancer immunotherapies: an evolving paradigm - Frontiers

IL-2 based cancer immunotherapies: an evolving paradigm  Frontiers

Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strateg...

Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies  Molecular Cancer

A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models - JC...

A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models  JCI.org

IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective...

IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein  Science | AAAS

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothe...

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells  PNAS

Emerging mechanisms and applications of low-dose IL-2 therapy in autoimmunity - ScienceDirect.com

Emerging mechanisms and applications of low-dose IL-2 therapy in autoimmunity  ScienceDirect.com

Harnessing IL-2 for immunotherapy against cancer and chronic infection: a historical perspective ...

Harnessing IL-2 for immunotherapy against cancer and chronic infection: a historical perspective and emerging trends  Nature

Exogenous IL-2 delays memory precursors generation and is essential for enhancing memory cells ef...

Exogenous IL-2 delays memory precursors generation and is essential for enhancing memory cells effector functions  ScienceDirect.com

PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function - Nature

PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function  Nature

Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with redu...

Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with reduced toxicity  JCI.org

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program - Nature

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program  Nature

Autocrine and paracrine IL-2 signals collaborate to regulate distinct phases of CD8 T cell memory...

Autocrine and paracrine IL-2 signals collaborate to regulate distinct phases of CD8 T cell memory  ScienceDirect.com

Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor ...

Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor  PNAS

A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy -...

A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy  Nature

Tumor-activated IL-2 mRNA delivered by lipid nanoparticles for cancer immunotherapy - ScienceDire...

Tumor-activated IL-2 mRNA delivered by lipid nanoparticles for cancer immunotherapy  ScienceDirect.com

Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and...

Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity | Signal Transduction and Targeted Therapy  Nature

BCANTT 2024: Rationally Engineered IL2 for Enhanced Treatment of Local and Metastatic Bladder Can...

BCANTT 2024: Rationally Engineered IL2 for Enhanced Treatment of Local and Metastatic Bladder Cancer  UroToday

An engineered IL-2 partial agonist promotes CD8+ T cell stemness - Nature

An engineered IL-2 partial agonist promotes CD8+ T cell stemness  Nature

IL-2 immunotherapy for targeting regulatory T cells in autoimmunity - Genes & Immunity - Nature

IL-2 immunotherapy for targeting regulatory T cells in autoimmunity - Genes & Immunity  Nature

IL-2-free tumor-infiltrating lymphocyte therapy with PD-1 blockade demonstrates potent efficacy i...

IL-2-free tumor-infiltrating lymphocyte therapy with PD-1 blockade demonstrates potent efficacy in advanced gynecologic cancer  BMC Medicine

Competition for IL-2 between Regulatory and Effector T Cells to Chisel Immune Responses - Frontiers

Competition for IL-2 between Regulatory and Effector T Cells to Chisel Immune Responses  Frontiers

Competitive inhibition of IL-2/IL-2R has a dual effect on HSC ex vivo expansion and IL-2R (CD25) ...

Competitive inhibition of IL-2/IL-2R has a dual effect on HSC ex vivo expansion and IL-2R (CD25) content  ScienceDirect.com

IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function - Sci...

IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function  ScienceDirect.com

Membrane-bound IL-2 improves the expansion, survival, and phenotype of CAR Tregs and confers resi...

Membrane-bound IL-2 improves the expansion, survival, and phenotype of CAR Tregs and confers resistance to calcineurin inhibitors  Frontiers

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulator...

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation  Nature

Engineering IL-2 for immunotherapy of autoimmunity and cancer - Nature

Engineering IL-2 for immunotherapy of autoimmunity and cancer  Nature

Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung...

Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung allograft acceptance in mice  Nature

De novo design of potent and selective mimics of IL-2 and IL-15 - Nature

De novo design of potent and selective mimics of IL-2 and IL-15  Nature

Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells - Nature

Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells  Nature

A chemically inducible IL-2 receptor signaling complex allows for effective in vitro and in vivo ...

A chemically inducible IL-2 receptor signaling complex allows for effective in vitro and in vivo selection of engineered CD4+ T cells  ScienceDirect.com

Interleukin-2 immunotherapy reveals human regulatory T cell subsets with distinct functional and ...

Interleukin-2 immunotherapy reveals human regulatory T cell subsets with distinct functional and tissue-homing characteristics  ScienceDirect.com

A single-agent fusion of human IL-2 and anti-IL-2 antibody that selectively expands regulatory T ...

A single-agent fusion of human IL-2 and anti-IL-2 antibody that selectively expands regulatory T cells  Nature

Molecular reshaping of phage-displayed Interleukin-2 at beta chain receptor interface to obtain p...

Molecular reshaping of phage-displayed Interleukin-2 at beta chain receptor interface to obtain potent super-agonists with improved developability profiles | Communications Biology  Nature

Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney tra...

Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney transplant recipients  Nature

Defining the Threshold IL-2 Signal Required for Induction of Selective Treg Cell Responses Using ...

Defining the Threshold IL-2 Signal Required for Induction of Selective Treg Cell Responses Using Engineered IL-2 Muteins  Frontiers

Engineered E. coli Nissle 1917 for delivery of bioactive IL-2 for cancer immunotherapy - Nature

Engineered E. coli Nissle 1917 for delivery of bioactive IL-2 for cancer immunotherapy  Nature

Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist...

Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist  Nature

Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulatio...

Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity  Nature

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes - Sci...

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes  Science | AAAS

Attenuated IL-2 muteins leverage the TCR signal to enhance regulatory T cell homeostasis and resp...

Attenuated IL-2 muteins leverage the TCR signal to enhance regulatory T cell homeostasis and response in vivo  Frontiers

An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer - Nature

An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer  Nature

A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo ...

A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells  Nature

IL-2 Complexed With Anti–IL-2 Antibody Expands the Maternal T-Regulatory Cell Pool and Alleviates...

IL-2 Complexed With Anti–IL-2 Antibody Expands the Maternal T-Regulatory Cell Pool and Alleviates Fetal Loss in Abortion-Prone Mice  ScienceDirect.com

Dynamically modeling the effective range of IL-2 dosage in the treatment of systemic lupus erythe...

Dynamically modeling the effective range of IL-2 dosage in the treatment of systemic lupus erythematosus  ScienceDirect.com

Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in ty...

Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes  Nature

A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in...

A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia  Science | AAAS

IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor ...

IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor | Nature Immunology  Nature

Regulatory T cells control toxicity in a humanized model of IL-2 therapy - Nature

Regulatory T cells control toxicity in a humanized model of IL-2 therapy  Nature

An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism - Nature

An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism  Nature

Measurement of IFN-γ and IL-2 for the assessment of the cellular immunity against SARS-CoV-2 - Na...

Measurement of IFN-γ and IL-2 for the assessment of the cellular immunity against SARS-CoV-2  Nature

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helpe...

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells  Science | AAAS

Bridging therapy-induced phenotypes and genetic immune dysregulation to study interleukin-2-induc...

Bridging therapy-induced phenotypes and genetic immune dysregulation to study interleukin-2-induced immunotoxicology  ScienceDirect.com

Differential Roles of IL-2 Signaling in Developing versus Mature Tregs - ScienceDirect.com

Differential Roles of IL-2 Signaling in Developing versus Mature Tregs  ScienceDirect.com

T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics - ...

T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics  Nature

Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue...

Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue  Nature

Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates ...

Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates dysfunctional CD8  Nature

A CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organism - Nature

A CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organism  Nature