Cubs Place Catcher Miguel Amaya on the 10-day IL, 2 Days After Activating Him - FOX Sports

Cubs Place Catcher Miguel Amaya on the 10-day IL, 2 Days After Activating Him  FOX Sports

TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8 - Nature

TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8  Nature

A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals - ...

A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals  Science | AAAS

Interleukin-2 and its receptors: Implications and therapeutic prospects in immune-mediated disord...

Interleukin-2 and its receptors: Implications and therapeutic prospects in immune-mediated disorders of central nervous system  ScienceDirect.com

Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, dou...

Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial  The Lancet

Sammy T. Simpson, 90 of Barnhill - wfiwradio.com

Sammy T. Simpson, 90 of Barnhill  wfiwradio.com

First-in-human evaluation of a no-alpha interleukin–2 mutein: safety and preliminary pharmacodyna...

First-in-human evaluation of a no-alpha interleukin–2 mutein: safety and preliminary pharmacodynamic and clinical effect  Frontiers

Low-dose interleukin-2 induces clonal expansion of BACH2-repressed effector regulatory T cells fo...

Low-dose interleukin-2 induces clonal expansion of BACH2-repressed effector regulatory T cells following acute coronary syndrome  Nature

IL-2 immunotherapy rescues irradiation-induced T cell exhaustion in mouse colon cancer - ScienceD...

IL-2 immunotherapy rescues irradiation-induced T cell exhaustion in mouse colon cancer  ScienceDirect.com

Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficac...

Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficacy in mouse autoimmune models  Nature

Directed disruption of IL2 aggregation and receptor binding sites produces designer biologics wit...

Directed disruption of IL2 aggregation and receptor binding sites produces designer biologics with enhanced specificity and improved production capacity  ScienceDirect.com

Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune respons...

Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune response  Nature

A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-media...

A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies  ScienceDirect.com

Biomineral tablets for long-acting IL-2 immunotherapy - Nature

Biomineral tablets for long-acting IL-2 immunotherapy  Nature

An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to...

An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to promote T cell anergy  ScienceDirect.com

CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation | Nature Communic...

CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation | Nature Communications  Nature

Dual IL-2/IL-21 priming augments the anti-tumor function of CD16V-CAR/TRAIL-engineered NK cells i...

Dual IL-2/IL-21 priming augments the anti-tumor function of CD16V-CAR/TRAIL-engineered NK cells in combination with monoclonal antibodies  ScienceDirect.com

An in situ engineered chimeric IL-2 receptor potentiates the tumoricidal activity of proinflammat...

An in situ engineered chimeric IL-2 receptor potentiates the tumoricidal activity of proinflammatory CAR macrophages in renal cell carcinoma  Nature

In Silico tool for predicting, designing and scanning IL-2 inducing peptides | Scientific Reports...

In Silico tool for predicting, designing and scanning IL-2 inducing peptides | Scientific Reports  Nature

Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 ove...

Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer  Nature

Interleukin-2 improves insulin sensitivity through hypothalamic sympathetic activation in obese m...

Interleukin-2 improves insulin sensitivity through hypothalamic sympathetic activation in obese mice  Journal of Neuroinflammation

Anti-cancer effect of interleukin-2 fused to flagellin expressed by tumor-targeting Salmonella - ...

Anti-cancer effect of interleukin-2 fused to flagellin expressed by tumor-targeting Salmonella  Nature

Regulating IL-2 Immune Signaling Function Via A Core Allosteric Structural Network - ScienceDirec...

Regulating IL-2 Immune Signaling Function Via A Core Allosteric Structural Network  ScienceDirect.com

Human serum albumin promotes interactions between HSA-IL-2 fusion protein and CD122 for enhancing...

Human serum albumin promotes interactions between HSA-IL-2 fusion protein and CD122 for enhancing immunotherapy  ScienceDirect.com

Novel [18F]FPG-interleukin-2 conjugate for monitoring immune checkpoint therapy with positron emi...

Novel [18F]FPG-interleukin-2 conjugate for monitoring immune checkpoint therapy with positron emission tomography  ScienceDirect.com

Examining the evidence for IL-2 in amyotrophic lateral sclerosis - The Lancet

Examining the evidence for IL-2 in amyotrophic lateral sclerosis  The Lancet

Abstract 4144964: Low-Dose IL-2 Lowers Arterial Inflammation and Trends Towards Lower MACE in pat...

Abstract 4144964: Low-Dose IL-2 Lowers Arterial Inflammation and Trends Towards Lower MACE in patients with ACS: The results of the IVORY trial and IVORY FINALE study  American Heart Association Journals

Predictive biomarkers for low-dose IL-2 therapy efficacy in systemic lupus erythematosus: a clini...

Predictive biomarkers for low-dose IL-2 therapy efficacy in systemic lupus erythematosus: a clinical analysis  Arthritis Research & Therapy

Scientists Identify Key Biomarkers That May Predict Low-Dose IL-2 Treatment Efficacy in People wi...

Scientists Identify Key Biomarkers That May Predict Low-Dose IL-2 Treatment Efficacy in People with Systemic Lupus Erythematosus  Lupus Foundation of America

WW2 Flight Sim Il-2 Sturmovik Announces Final Expansion Before New Korea Game - DualShockers

WW2 Flight Sim Il-2 Sturmovik Announces Final Expansion Before New Korea Game  DualShockers

Early Serum IL-2 Levels Are Associated With CAR T-Cell Expansion Post–CAR T-Cell Therapy - OncLive

Early Serum IL-2 Levels Are Associated With CAR T-Cell Expansion Post–CAR T-Cell Therapy  OncLive

Based on the immune system: the role of the IL-2 family in pancreatic disease - Frontiers

Based on the immune system: the role of the IL-2 family in pancreatic disease  Frontiers

Spatial microniches of IL-2 combine with IL-10 to drive lung migratory T - Nature

Spatial microniches of IL-2 combine with IL-10 to drive lung migratory T  Nature

Targeting systemic IL-2 to BCMA CAR-T cells - Nature

Targeting systemic IL-2 to BCMA CAR-T cells  Nature

Interleukin-2 immunotherapy reveals human regulatory T cell subsets with distinct functional and ...

Interleukin-2 immunotherapy reveals human regulatory T cell subsets with distinct functional and tissue-homing characteristics  ScienceDirect.com

T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics - ...

T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics  Nature

Harnessing IL-2 for immunotherapy against cancer and chronic infection: a historical perspective ...

Harnessing IL-2 for immunotherapy against cancer and chronic infection: a historical perspective and emerging trends  Nature

Novel design of potent anti-tumour activity of IL-2 prodrug by FAPα-mediated activation - Science...

Novel design of potent anti-tumour activity of IL-2 prodrug by FAPα-mediated activation  ScienceDirect.com

Cubs pitcher Soroka headed to IL after 2 innings with new team - CBC

Cubs pitcher Soroka headed to IL after 2 innings with new team  CBC

Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T ...

Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation  Nature

IL-2 based cancer immunotherapies: an evolving paradigm - Frontiers

IL-2 based cancer immunotherapies: an evolving paradigm  Frontiers

IL-2 family cytokines IL-9 and IL-21 differentially regulate innate and adaptive type 2 immunity ...

IL-2 family cytokines IL-9 and IL-21 differentially regulate innate and adaptive type 2 immunity in asthma  ScienceDirect.com

10-Day Weather Forecast for Chicago, IL - The Weather Channel | weather.com - The Weather Channel

10-Day Weather Forecast for Chicago, IL - The Weather Channel | weather.com  The Weather Channel

Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strateg...

Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies  Molecular Cancer

A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models - JC...

A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models  JCI.org

Exogenous IL-2 delays memory precursors generation and is essential for enhancing memory cells ef...

Exogenous IL-2 delays memory precursors generation and is essential for enhancing memory cells effector functions  ScienceDirect.com

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothe...

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells  PNAS

Emerging mechanisms and applications of low-dose IL-2 therapy in autoimmunity - ScienceDirect.com

Emerging mechanisms and applications of low-dose IL-2 therapy in autoimmunity  ScienceDirect.com

CD8 cis-targeted IL-2 drives potent antiviral activity against hepatitis B virus - Science | AAAS

CD8 cis-targeted IL-2 drives potent antiviral activity against hepatitis B virus  Science | AAAS

PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function - Nature

PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function  Nature

Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor ...

Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor  PNAS

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program - Nature

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program  Nature

Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with redu...

Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with reduced toxicity  JCI.org

Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and...

Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity | Signal Transduction and Targeted Therapy  Nature

Tumor-activated IL-2 mRNA delivered by lipid nanoparticles for cancer immunotherapy - ScienceDire...

Tumor-activated IL-2 mRNA delivered by lipid nanoparticles for cancer immunotherapy  ScienceDirect.com

A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy -...

A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy  Nature

IL-2-free tumor-infiltrating lymphocyte therapy with PD-1 blockade demonstrates potent efficacy i...

IL-2-free tumor-infiltrating lymphocyte therapy with PD-1 blockade demonstrates potent efficacy in advanced gynecologic cancer  BMC Medicine

IL-2 immunotherapy for targeting regulatory T cells in autoimmunity - Genes & Immunity - Nature

IL-2 immunotherapy for targeting regulatory T cells in autoimmunity - Genes & Immunity  Nature

IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function - Sci...

IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function  ScienceDirect.com

An engineered IL-2 partial agonist promotes CD8+ T cell stemness - Nature

An engineered IL-2 partial agonist promotes CD8+ T cell stemness  Nature

Engineering IL-2 for immunotherapy of autoimmunity and cancer - Nature

Engineering IL-2 for immunotherapy of autoimmunity and cancer  Nature

Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells - Nature

Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells  Nature

Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung...

Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung allograft acceptance in mice  Nature

An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity...

An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice  Science | AAAS

A single-agent fusion of human IL-2 and anti-IL-2 antibody that selectively expands regulatory T ...

A single-agent fusion of human IL-2 and anti-IL-2 antibody that selectively expands regulatory T cells  Nature

Localization of Salmonella and albumin-IL-2 to the tumor microenvironment augments anticancer T c...

Localization of Salmonella and albumin-IL-2 to the tumor microenvironment augments anticancer T cell immunity  Journal of Biomedical Science

Competitive inhibition of IL-2/IL-2R has a dual effect on HSC ex vivo expansion and IL-2R (CD25) ...

Competitive inhibition of IL-2/IL-2R has a dual effect on HSC ex vivo expansion and IL-2R (CD25) content  ScienceDirect.com

Membrane-bound IL-2 improves the expansion, survival, and phenotype of CAR Tregs and confers resi...

Membrane-bound IL-2 improves the expansion, survival, and phenotype of CAR Tregs and confers resistance to calcineurin inhibitors  Frontiers

Competition for IL-2 between Regulatory and Effector T Cells to Chisel Immune Responses - Frontiers

Competition for IL-2 between Regulatory and Effector T Cells to Chisel Immune Responses  Frontiers

Defining the Threshold IL-2 Signal Required for Induction of Selective Treg Cell Responses Using ...

Defining the Threshold IL-2 Signal Required for Induction of Selective Treg Cell Responses Using Engineered IL-2 Muteins  Frontiers

De novo design of potent and selective mimics of IL-2 and IL-15 - Nature

De novo design of potent and selective mimics of IL-2 and IL-15  Nature

Attenuated IL-2 muteins leverage the TCR signal to enhance regulatory T cell homeostasis and resp...

Attenuated IL-2 muteins leverage the TCR signal to enhance regulatory T cell homeostasis and response in vivo  Frontiers

A chemically inducible IL-2 receptor signaling complex allows for effective in vitro and in vivo ...

A chemically inducible IL-2 receptor signaling complex allows for effective in vitro and in vivo selection of engineered CD4+ T cells  ScienceDirect.com

Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulatio...

Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity  Nature

Molecular reshaping of phage-displayed Interleukin-2 at beta chain receptor interface to obtain p...

Molecular reshaping of phage-displayed Interleukin-2 at beta chain receptor interface to obtain potent super-agonists with improved developability profiles | Communications Biology  Nature

Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney tra...

Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney transplant recipients  Nature

Bridging therapy-induced phenotypes and genetic immune dysregulation to study interleukin-2-induc...

Bridging therapy-induced phenotypes and genetic immune dysregulation to study interleukin-2-induced immunotoxicology  ScienceDirect.com

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulator...

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation  Nature

An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer - Nature

An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer  Nature

Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue...

Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue  Nature

Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist...

Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist  Nature

A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in...

A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia  Science | AAAS

A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo ...

A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells  Nature

Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates ...

Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates dysfunctional CD8  Nature

The antitumor effect induced by an IL-2 ‘no-alpha’ mutein depends on changes in the CD8 - Frontiers

The antitumor effect induced by an IL-2 ‘no-alpha’ mutein depends on changes in the CD8  Frontiers

IL-2 Signaling Axis Defects: How Many Faces? - Frontiers

IL-2 Signaling Axis Defects: How Many Faces?  Frontiers

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes - Sci...

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes  Science | AAAS

Differential Roles of IL-2 Signaling in Developing versus Mature Tregs - ScienceDirect.com

Differential Roles of IL-2 Signaling in Developing versus Mature Tregs  ScienceDirect.com

Measurement of IFN-γ and IL-2 for the assessment of the cellular immunity against SARS-CoV-2 - Na...

Measurement of IFN-γ and IL-2 for the assessment of the cellular immunity against SARS-CoV-2  Nature

T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes - Nature

T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes  Nature

A promising option for unremitting ulcerative colitis: Low-dose IL-2 - Boston Children's Answers

A promising option for unremitting ulcerative colitis: Low-dose IL-2  Boston Children's Answers

Engineered E. coli Nissle 1917 for delivery of bioactive IL-2 for cancer immunotherapy - Nature

Engineered E. coli Nissle 1917 for delivery of bioactive IL-2 for cancer immunotherapy  Nature

Efficacy and antitumor activity of a mutant type of interleukin 2 - Nature

Efficacy and antitumor activity of a mutant type of interleukin 2  Nature

An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism - Nature

An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism  Nature

A CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organism - Nature

A CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organism  Nature

BCANTT 2024: Rationally Engineered IL2 for Enhanced Treatment of Local and Metastatic Bladder Can...

BCANTT 2024: Rationally Engineered IL2 for Enhanced Treatment of Local and Metastatic Bladder Cancer  UroToday

IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor ...

IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor | Nature Immunology  Nature

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helpe...

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells  Science | AAAS

Overcoming toxicities: are IL-2 smart cytokines the next big thing? - Labiotech.eu

Overcoming toxicities: are IL-2 smart cytokines the next big thing?  Labiotech.eu

Dynamically modeling the effective range of IL-2 dosage in the treatment of systemic lupus erythe...

Dynamically modeling the effective range of IL-2 dosage in the treatment of systemic lupus erythematosus  ScienceDirect.com