αTIGIT-IL2 achieves tumor regression by promoting tumor-infiltrating regulatory T cell fragility ...

αTIGIT-IL2 achieves tumor regression by promoting tumor-infiltrating regulatory T cell fragility in mouse models  Nature

IL-2 and GLP-1 receptor agonist combination tackles neuroinflammation - Drug Target Review

IL-2 and GLP-1 receptor agonist combination tackles neuroinflammation  Drug Target Review

FDA Clears IND Application for Novel IL-2 Agent in Advanced NSCLC - CancerNetwork

FDA Clears IND Application for Novel IL-2 Agent in Advanced NSCLC  CancerNetwork

Low-Dose IL-2 Rebalances Immunity in SLE, With Yuebo Jin, MD - HCPLive

Low-Dose IL-2 Rebalances Immunity in SLE, With Yuebo Jin, MD  HCPLive

FDA Clears IND for GL-IL2-138 in Cancer and Beyond - Targeted Oncology

FDA Clears IND for GL-IL2-138 in Cancer and Beyond  Targeted Oncology

Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, dou...

Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial  The Lancet

BLIMP1 negatively regulates IL-2 signaling in T cells - Science | AAAS

BLIMP1 negatively regulates IL-2 signaling in T cells  Science | AAAS

Coya Therapeutics Announces That Its Combination LD IL-2/GLP-1 RA Candidate (COYA 303) Demonstrat...

Coya Therapeutics Announces That Its Combination LD IL-2/GLP-1 RA Candidate (COYA 303) Demonstrated Potent Systemic and Brain Anti-Inflammatory Efficacy In Vivo  Yahoo Finance

Nektar says IL-2 pathway agonist rejected by Lilly succeeds in atopic dermatitis trial - FirstWor...

Nektar says IL-2 pathway agonist rejected by Lilly succeeds in atopic dermatitis trial  FirstWord Pharma

TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion | Nature Com...

TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion | Nature Communications  Nature

Claude on Google Cloud’s Vertex AI: FedRAMP High and IL2 Authorized - Anthropic

Claude on Google Cloud’s Vertex AI: FedRAMP High and IL2 Authorized  Anthropic

Mural risks going to the wall as IL-2 flop triggers 90% staff reduction, hunt for strategic alter...

Mural risks going to the wall as IL-2 flop triggers 90% staff reduction, hunt for strategic alternatives  Fierce Biotech

PD-1 + IL-2 power couple: Wake up 'sleepy' T cells to turbo-charge cancer cures - EurekAlert!

PD-1 + IL-2 power couple: Wake up 'sleepy' T cells to turbo-charge cancer cures  EurekAlert!

In-situ trichosanthin-IL2/pectin dynamic hydrogel activates dendritic cells and reverses T cell e...

In-situ trichosanthin-IL2/pectin dynamic hydrogel activates dendritic cells and reverses T cell exhaustion for post-operative cancer therapy  ScienceDirect.com

PD-1 x IL-2 antibody fusions: The next Keytruda competitors? - BioCentury

PD-1 x IL-2 antibody fusions: The next Keytruda competitors?  BioCentury

A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals - ...

A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals  Science | AAAS

In Silico tool for predicting, designing and scanning IL-2 inducing peptides | Scientific Reports...

In Silico tool for predicting, designing and scanning IL-2 inducing peptides | Scientific Reports  Nature

An in situ engineered chimeric IL-2 receptor potentiates the tumoricidal activity of proinflammat...

An in situ engineered chimeric IL-2 receptor potentiates the tumoricidal activity of proinflammatory CAR macrophages in renal cell carcinoma  Nature

Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune respons...

Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune response  Nature

CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation | Nature Communic...

CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation | Nature Communications  Nature

Regulatory T cell therapy promotes TGF-β and IL-6-dependent pro-inflammatory Th17 cell generation...

Regulatory T cell therapy promotes TGF-β and IL-6-dependent pro-inflammatory Th17 cell generation by reducing IL-2  Nature

First-in-Class IL-2 Pathway Agonist Advances in AD - Dermatology Times

First-in-Class IL-2 Pathway Agonist Advances in AD  Dermatology Times

The Interleukin-2 Market is Set to Reach USD 4 Billion by 2034, Driven by IL-2 Targeting Fusion P...

The Interleukin-2 Market is Set to Reach USD 4 Billion by 2034, Driven by IL-2 Targeting Fusion Proteins, Monoclonal antibodies, and Gene Therapies Across Immunology, Dermatology, Neurodegenerative Disorders, and Oncology | DelveInsight  PR Newswire

Examining the evidence for IL-2 in amyotrophic lateral sclerosis - The Lancet

Examining the evidence for IL-2 in amyotrophic lateral sclerosis  The Lancet

Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 ove...

Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer  Nature

Adding low-dose IL-2 to riluzole may improve survival in ALS - ALS News Today

Adding low-dose IL-2 to riluzole may improve survival in ALS  ALS News Today

Biomineral tablets for long-acting IL-2 immunotherapy - Nature

Biomineral tablets for long-acting IL-2 immunotherapy  Nature

A glimpse into the application of the immunomodulatory effect of IL-2 in systemic lupus erythemat...

A glimpse into the application of the immunomodulatory effect of IL-2 in systemic lupus erythematosus  Frontiers

Coya Therapeutics Announces That Its Combination LD IL-2/GLP-1 RA Candidate (COYA 303) Demonstrat...

Coya Therapeutics Announces That Its Combination LD IL-2/GLP-1 RA Candidate (COYA 303) Demonstrated Potent Systemic and Brain Anti-Inflammatory Efficacy In Vivo  Eagle-Tribune

Coordinating interleukin-2 encoding circRNA with immunomodulatory lipid nanoparticles to potentia...

Coordinating interleukin-2 encoding circRNA with immunomodulatory lipid nanoparticles to potentiate cancer immunotherapy  Science | AAAS

National Air and Space Museum Completes Restoration of Ilyushin Il-2 Shturmovik - Vintage Aviatio...

National Air and Space Museum Completes Restoration of Ilyushin Il-2 Shturmovik  Vintage Aviation News

Teva and Fosun Pharma Enter into a Strategic Partnership to Develop Novel Anti-PD1-IL2 Therapy (T...

Teva and Fosun Pharma Enter into a Strategic Partnership to Develop Novel Anti-PD1-IL2 Therapy (TEV-56278) in Immuno-Oncology  Yahoo Finance

Molecular design and characterization of AB248, a CD8 cis-targeted IL2.... - researchgate.net

Molecular design and characterization of AB248, a CD8 cis-targeted IL2....  researchgate.net

Reshape the Fates of Treg and CD8+T Cells Through IL-2Rα by Synergizing Divergent Receptor-Biased...

Reshape the Fates of Treg and CD8+T Cells Through IL-2Rα by Synergizing Divergent Receptor-Biased IL-2 PEGylates  Wiley

Low-Dose IL-2 Shows Promise in Early Alzheimer’s Trial - European Medical Journal

Low-Dose IL-2 Shows Promise in Early Alzheimer’s Trial  European Medical Journal

[ESMO 2025] GI Innovation’s IL-2 therapy shows tumor response in ICB-resistant cancers - koreabio...

[ESMO 2025] GI Innovation’s IL-2 therapy shows tumor response in ICB-resistant cancers  koreabiomed.com

Teva's Breakthrough Cancer Immunotherapy Gains Momentum with Major Asian Market Partnership - Sto...

Teva's Breakthrough Cancer Immunotherapy Gains Momentum with Major Asian Market Partnership  Stock Titan

WW2 Flight Sim Il-2 Sturmovik Announces Final Expansion Before New Korea Game - DualShockers

WW2 Flight Sim Il-2 Sturmovik Announces Final Expansion Before New Korea Game  DualShockers

Topline atopic dermatitis data showcase IL-2 modulator’s ‘incredibly novel’ mechanism - Healio

Topline atopic dermatitis data showcase IL-2 modulator’s ‘incredibly novel’ mechanism  Healio

Genetic Leap to advance IL-2 modulator into clinic - BioWorld MedTech

Genetic Leap to advance IL-2 modulator into clinic  BioWorld MedTech

Nektar touts 'deepening clinical effect' of IL-2 agonist in atopic dermatitis - FirstWord Pharma

Nektar touts 'deepening clinical effect' of IL-2 agonist in atopic dermatitis  FirstWord Pharma

CD2-targeted nanoparticles encapsulating IL-2 induce tolerogenic Tregs and TGF-β-producing NK cel...

CD2-targeted nanoparticles encapsulating IL-2 induce tolerogenic Tregs and TGF-β-producing NK cells that stabilize Tregs for long-term therapeutic efficacy in immune-mediated disorders  Frontiers

Based on the immune system: the role of the IL-2 family in pancreatic disease - Frontiers

Based on the immune system: the role of the IL-2 family in pancreatic disease  Frontiers

CD8 cis-targeted IL-2 drives potent antiviral activity against hepatitis B virus - Science | AAAS

CD8 cis-targeted IL-2 drives potent antiviral activity against hepatitis B virus  Science | AAAS

IL-2 based cancer immunotherapies: an evolving paradigm - Frontiers

IL-2 based cancer immunotherapies: an evolving paradigm  Frontiers

A cytokine receptor-masked IL2 prodrug selectively activates tumor-infiltrating lymphocytes for p...

A cytokine receptor-masked IL2 prodrug selectively activates tumor-infiltrating lymphocytes for potent antitumor therapy  Nature

A tetraspecific engager armed with a non-alpha IL-2 variant harnesses natural killer cells agains...

A tetraspecific engager armed with a non-alpha IL-2 variant harnesses natural killer cells against B cell non-Hodgkin lymphoma  Science | AAAS

Engineered IL-2 molecule shows promise in treating autoimmune disease - McGill University

Engineered IL-2 molecule shows promise in treating autoimmune disease  McGill University

BCANTT 2024: Rationally Engineered IL2 for Enhanced Treatment of Local and Metastatic Bladder Can...

BCANTT 2024: Rationally Engineered IL2 for Enhanced Treatment of Local and Metastatic Bladder Cancer  UroToday

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program - Nature

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program  Nature

Basiliximab for IL‐2‐Associated Inflammatory Disorder With Atopic Dermatitis - Becker - Pediatric...

Basiliximab for IL‐2‐Associated Inflammatory Disorder With Atopic Dermatitis - Becker - Pediatric Dermatology  Wiley Online Library

Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor ...

Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor  PNAS

Harnessing IL-2 for immunotherapy against cancer and chronic infection: a historical perspective ...

Harnessing IL-2 for immunotherapy against cancer and chronic infection: a historical perspective and emerging trends  Nature

A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy -...

A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy  Nature

Dual role of IL-2 signaling mediated by different IL-2 receptor... - researchgate.net

Dual role of IL-2 signaling mediated by different IL-2 receptor...  researchgate.net

IL-2R structure and signaling. The IL-2 receptor (IL-2R) has three... - researchgate.net

IL-2R structure and signaling. The IL-2 receptor (IL-2R) has three...  researchgate.net

Synthekine nabs $100M to boost IL-2 programs after rivals hit setbacks - Endpoints News

Synthekine nabs $100M to boost IL-2 programs after rivals hit setbacks  Endpoints News

PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function - Nature

PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function  Nature

IL-2 treatment can be dangerous. Here’s how drug firms are trying to fix it - Chemical & Engineer...

IL-2 treatment can be dangerous. Here’s how drug firms are trying to fix it  Chemical & Engineering News

A single-agent fusion of human IL-2 and anti-IL-2 antibody that selectively expands regulatory T ...

A single-agent fusion of human IL-2 and anti-IL-2 antibody that selectively expands regulatory T cells  Nature

Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2...

Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain  EMBO Press

An engineered IL-2 partial agonist promotes CD8+ T cell stemness - Nature

An engineered IL-2 partial agonist promotes CD8+ T cell stemness  Nature

IL-2 Sturmovik Flying Circus Vol. IV Released - FSElite

IL-2 Sturmovik Flying Circus Vol. IV Released  FSElite

De novo design of potent and selective mimics of IL-2 and IL-15 - Nature

De novo design of potent and selective mimics of IL-2 and IL-15  Nature

Fig. 4. IL-2-induced T cell proliferation in the presence of high-dose... - researchgate.net

Fig. 4. IL-2-induced T cell proliferation in the presence of high-dose...  researchgate.net

Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and...

Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity  Nature

Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates ...

Targeting tumor microenvironment with antibody-guided IL-2 pro-cytokine promotes and rejuvenates dysfunctional CD8  Nature

Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulatio...

Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity  Nature

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes - Sci...

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes  Science | AAAS

Early Serum IL-2 Levels Are Associated With CAR T-Cell Expansion Post–CAR T-Cell Therapy - OncLive

Early Serum IL-2 Levels Are Associated With CAR T-Cell Expansion Post–CAR T-Cell Therapy  OncLive

IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor ...

IL-2 regulates tumor-reactive CD8+ T cell exhaustion by activating the aryl hydrocarbon receptor | Nature Immunology  Nature

Regulating IL-2 Immune Signaling Function Via A Core Allosteric Structural Network - ScienceDirec...

Regulating IL-2 Immune Signaling Function Via A Core Allosteric Structural Network  ScienceDirect.com

A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8 - Nature

A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8  Nature

Measurement of IFN-γ and IL-2 for the assessment of the cellular immunity against SARS-CoV-2 - Na...

Measurement of IFN-γ and IL-2 for the assessment of the cellular immunity against SARS-CoV-2  Nature

IL-2- and IFN-γ-producing CD4⁺ T cells and CD8⁺ T cells in splenocytes... - researchgate.net

IL-2- and IFN-γ-producing CD4⁺ T cells and CD8⁺ T cells in splenocytes...  researchgate.net

An essential role for the IL-2 receptor in T - Nature

An essential role for the IL-2 receptor in T  Nature

Engineered E. coli Nissle 1917 for delivery of bioactive IL-2 for cancer immunotherapy - Nature

Engineered E. coli Nissle 1917 for delivery of bioactive IL-2 for cancer immunotherapy  Nature

A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo ...

A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells  Nature

Low-Dose IL-2 Shows Promise for Allergic Rhinitis Relief - European Medical Journal

Low-Dose IL-2 Shows Promise for Allergic Rhinitis Relief  European Medical Journal

T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes - Nature

T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes  Nature

Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue...

Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue  Nature

IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8 - Nature

IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8  Nature

Effects of rIL2/anti-IL2 antibody complex on chikungunya virus-induced chronic arthritis in a mou...

Effects of rIL2/anti-IL2 antibody complex on chikungunya virus-induced chronic arthritis in a mouse model  Nature

Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells - Nature

Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells  Nature

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothe...

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells  PNAS

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helpe...

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells  Science | AAAS

Scientists Identify Key Biomarkers That May Predict Low-Dose IL-2 Treatment Efficacy in People wi...

Scientists Identify Key Biomarkers That May Predict Low-Dose IL-2 Treatment Efficacy in People with Systemic Lupus Erythematosus  Lupus Foundation of America

Engineering IL-2 for immunotherapy of autoimmunity and cancer - Nature

Engineering IL-2 for immunotherapy of autoimmunity and cancer  Nature

IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repress...

IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression  Nature

TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the no...

TNFR2 ligation in human T regulatory cells enhances IL2-induced cell proliferation through the non-canonical NF-κB pathway  Nature

Spatial microniches of IL-2 combine with IL-10 to drive lung migratory T - Nature

Spatial microniches of IL-2 combine with IL-10 to drive lung migratory T  Nature

Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a...

Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein  Nature

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism - N...

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism  Nature

Efficacy and antitumor activity of a mutant type of interleukin 2 - Nature

Efficacy and antitumor activity of a mutant type of interleukin 2  Nature

Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with a...

Efficacy and safety of low-dose interleukin-2 in combination with methotrexate in patients with active rheumatoid arthritis: a randomized, double-blind, placebo-controlled phase 2 trial  Nature

Low-Dose IL-2 Therapy in Autoimmune and Rheumatic Diseases - Frontiers

Low-Dose IL-2 Therapy in Autoimmune and Rheumatic Diseases  Frontiers

IL6 suppresses vaccine responses in neonates by enhancing IL2 activity on T follicular helper cel...

IL6 suppresses vaccine responses in neonates by enhancing IL2 activity on T follicular helper cells  Nature

Harnessing immune power against tumours - Roche

Harnessing immune power against tumours  Roche

Implanted “Drug Factories” Deliver Cancer Treatment Directly to Tumors - National Cancer Institut...

Implanted “Drug Factories” Deliver Cancer Treatment Directly to Tumors  National Cancer Institute (.gov)

An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism - Nature

An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism  Nature