"MEK" の関連情報検索結果

Coinhibition of the MEK/RTK pathway has high therapeutic efficacy in KRAS-mutant non-small cell l...



Coinhibition of the MEK/RTK pathway has high therapeutic efficacy in KRAS-mutant non-small cell lung cancer  Nature

Basroparib overcomes acquired resistance to MEK inhibitors by inhibiting Wnt-mediated cancer stem...



Basroparib overcomes acquired resistance to MEK inhibitors by inhibiting Wnt-mediated cancer stemness in KRAS-mutated colorectal cancer  ScienceDirect.com

Free Iran 2025– Maryam Rajavi’s Remarks on the MEK’s 60th Anniversary - National Council of Resis...



Free Iran 2025– Maryam Rajavi’s Remarks on the MEK’s 60th Anniversary  National Council of Resistance of Iran - NCRI

Impact of MEK Inhibition on Childhood RASopathy-Associated Hypertrophic Cardiomyopathy - JACC Jou...



Impact of MEK Inhibition on Childhood RASopathy-Associated Hypertrophic Cardiomyopathy  JACC Journals

The role of MEK inhibition in pediatric low-grade gliomas - Frontiers



The role of MEK inhibition in pediatric low-grade gliomas  Frontiers

Dr Moertel on the Importance of Managing MEK Inhibitor–Associated Toxicites in NF1-Associated PN ...



Dr Moertel on the Importance of Managing MEK Inhibitor–Associated Toxicites in NF1-Associated PN  OncLive

Blocking Nitrosylation Boosts MEK Inhibitors in Aggressive Melanoma - Targeted Oncology



Blocking Nitrosylation Boosts MEK Inhibitors in Aggressive Melanoma  Targeted Oncology

Cx43 enhances response to BRAF/MEK inhibitors by reducing DNA repair capacity - Nature



Cx43 enhances response to BRAF/MEK inhibitors by reducing DNA repair capacity  Nature

DCP1A, a MEK substrate, regulates the self-renewal and differentiation of mouse embryonic stem ce...



DCP1A, a MEK substrate, regulates the self-renewal and differentiation of mouse embryonic stem cells  ScienceDirect.com

Efficacy of MEK inhibitors in Erdheim-Chester disease: impact of MAPK pathway pathogenic variants...



Efficacy of MEK inhibitors in Erdheim-Chester disease: impact of MAPK pathway pathogenic variants | Leukemia  Nature

FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and ...



FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma  ScienceDirect.com

The MEK inhibitor trametinib is effective in inhibiting the growth of canine oral squamous cell c...



The MEK inhibitor trametinib is effective in inhibiting the growth of canine oral squamous cell carcinoma  Nature

BRAF/MEK inhibition induces cell state transitions boosting immune checkpoint sensitivity in BRAF...



BRAF/MEK inhibition induces cell state transitions boosting immune checkpoint sensitivity in BRAF  ScienceDirect.com

MEK inhibitors are effective in Erdheim–Chester disease regardless of MAPK pathway mutations | Le...



MEK inhibitors are effective in Erdheim–Chester disease regardless of MAPK pathway mutations | Leukemia  Nature

Novel high throughput 3D ECM remodeling assay identifies MEK as key driver of fibrotic fibroblast...



Novel high throughput 3D ECM remodeling assay identifies MEK as key driver of fibrotic fibroblast activity  ScienceDirect.com

Case report: Successful use of MEK inhibitors as an adjuvant approach in the treatment of pediatr...



Case report: Successful use of MEK inhibitors as an adjuvant approach in the treatment of pediatric MAP4 RAF1 fusion-positive solid tumor  Nature

Heme promotes venetoclax resistance in multiple myeloma through MEK-ERK signaling and purine bios...



Heme promotes venetoclax resistance in multiple myeloma through MEK-ERK signaling and purine biosynthesis  ScienceDirect.com

Targeting gut microbiota and arginase boosts MEK inhibitors’ enhancement of antitumour immunity v...



Targeting gut microbiota and arginase boosts MEK inhibitors’ enhancement of antitumour immunity via MHC-I upregulation in colorectal cancer  Nature

MEK inhibition prevents human skin graft rejection by promoting CD8+TCF1+ over CD8 effector T cel...



MEK inhibition prevents human skin graft rejection by promoting CD8+TCF1+ over CD8 effector T cells  ScienceDirect.com

Concurrent SOS1 and MEK suppression inhibits signaling and growth of NF1-null melanoma - ScienceD...



Concurrent SOS1 and MEK suppression inhibits signaling and growth of NF1-null melanoma  ScienceDirect.com

Fifth International Diada Castellera: A Human Tower Will Be Built at the MEK on 3 May 2025 - Staa...



Fifth International Diada Castellera: A Human Tower Will Be Built at the MEK on 3 May 2025  Staatliche Museen zu Berlin

Toluene, styrene and methyl-ethyl-ketone inhalation: Effects on the power of cortical oscillation...



Toluene, styrene and methyl-ethyl-ketone inhalation: Effects on the power of cortical oscillations in rats  ScienceDirect.com

ELABELA targets the MEK/ERK axis to enhance trophoblast invasion in early-onset preeclampsia - Na...



ELABELA targets the MEK/ERK axis to enhance trophoblast invasion in early-onset preeclampsia  Nature

Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melano...



Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases  ScienceDirect.com

Adjuvant BRAF/MEK versus anti-PD-1 in BRAF-mutant melanoma: a propensity score matched survival a...



Adjuvant BRAF/MEK versus anti-PD-1 in BRAF-mutant melanoma: a propensity score matched survival analysis  Nature

The clinically relevant MEK inhibitor mirdametinib combined with D-cycloserine and prediction err...



The clinically relevant MEK inhibitor mirdametinib combined with D-cycloserine and prediction error disrupts fear memory in PTSD models  Nature

Effective Toxicity Management is Key to Maximizing Benefit With MEK Inhibitors in NF1-Associated ...



Effective Toxicity Management is Key to Maximizing Benefit With MEK Inhibitors in NF1-Associated PN  OncLive

KOMET in the landscape of MEK inhibitor clinical trials for plexiform neurofibromas - The Lancet



KOMET in the landscape of MEK inhibitor clinical trials for plexiform neurofibromas  The Lancet

mutation treated with BRAF/MEK-targeted therapy plus cetuximab: A case report - Baishideng Publis...



mutation treated with BRAF/MEK-targeted therapy plus cetuximab: A case report  Baishideng Publishing Group

MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and...



MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB  Nature

Impact of MEK Inhibition on Childhood RASopathy-Associated Hypertrophic Cardiomyopathy - JACC Jou...



Impact of MEK Inhibition on Childhood RASopathy-Associated Hypertrophic Cardiomyopathy  JACC Journals

Global trends and emerging insights in BRAF and MEK inhibitor resistance in melanoma: a bibliomet...



Global trends and emerging insights in BRAF and MEK inhibitor resistance in melanoma: a bibliometric analysis  Frontiers

Overcoming melanoma therapy resistance with RAF-MEK and FAK inhibition - ScienceDirect.com



Overcoming melanoma therapy resistance with RAF-MEK and FAK inhibition  ScienceDirect.com

Molecular profiling is critical to guide MEK inhibitor use in Erdheim-Chester disease | Leukemia ...



Molecular profiling is critical to guide MEK inhibitor use in Erdheim-Chester disease | Leukemia  Nature

Cutaneous adverse events associated with BRAF and MEK inhibitors: a systematic review and meta-an...



Cutaneous adverse events associated with BRAF and MEK inhibitors: a systematic review and meta-analysis  Frontiers

Extension for the Project on the Sámi Collection at MEK until November 2025 - Staatliche Museen z...



Extension for the Project on the Sámi Collection at MEK until November 2025  Staatliche Museen zu Berlin

A novel therapeutic strategy for leukopenia: Miltefosine activates the Ras/MEK/ERK pathway to pro...



A novel therapeutic strategy for leukopenia: Miltefosine activates the Ras/MEK/ERK pathway to promote neutrophil differentiation  ScienceDirect.com

Combustion reaction mechanisms of methyl ethyl ketone peroxide (MEKPO) via the integration of Rea...



Combustion reaction mechanisms of methyl ethyl ketone peroxide (MEKPO) via the integration of ReaxFF-MD and DFT  ScienceDirect.com

MEK inhibitors in maintenance of a postoperative patient with vasculopathy due to neurofibromatos...



MEK inhibitors in maintenance of a postoperative patient with vasculopathy due to neurofibromatosis type I  SciELO México

Mujahedin-e Khalq (MEK) - The People's Mojahedin Organization of Iran (PMOI) - National Council o...



Mujahedin-e Khalq (MEK) - The People's Mojahedin Organization of Iran (PMOI)  National Council of Resistance of Iran - NCRI

Cardiotoxicity of BRAF/MEK Inhibitors Mimicking Apical Hypertrophic Cardiomyopathy - Cureus



Cardiotoxicity of BRAF/MEK Inhibitors Mimicking Apical Hypertrophic Cardiomyopathy  Cureus

MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells - Scien...



MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells  ScienceDirect.com

The Trace of Maryam Rajavi in an Internal Tragedy of the MEK / What Do the MEK Do with Their Corp...



The Trace of Maryam Rajavi in an Internal Tragedy of the MEK / What Do the MEK Do with Their Corpses?  رکنا

Terrorists, cultists – or champions of Iranian democracy? The wild wild story of the MEK - The Gu...



Terrorists, cultists – or champions of Iranian democracy? The wild wild story of the MEK  The Guardian

Mujahadeen-e-Khalq (MEK) - Council on Foreign Relations



Mujahadeen-e-Khalq (MEK)  Council on Foreign Relations

Treatment decisions and the use of MEK inhibitors for children with neurofibromatosis type 1-rela...



Treatment decisions and the use of MEK inhibitors for children with neurofibromatosis type 1-related plexiform neurofibromas  BMC Cancer

MEK inhibitors: a promising targeted therapy for cardiovascular disease - Frontiers



MEK inhibitors: a promising targeted therapy for cardiovascular disease  Frontiers

MEK inhibitors for the treatment of non-small cell lung cancer - Journal of Hematology & Oncology



MEK inhibitors for the treatment of non-small cell lung cancer  Journal of Hematology & Oncology

Optimizing photoswitchable MEK - PNAS



Optimizing photoswitchable MEK  PNAS

T lymphocytes into memory stem cells with potent antitumor effects - Nature



T lymphocytes into memory stem cells with potent antitumor effects  Nature

Fine-tuning of MEK signaling is pivotal for limiting B and T cell activation - ScienceDirect.com



Fine-tuning of MEK signaling is pivotal for limiting B and T cell activation  ScienceDirect.com

Synergic activity of FGFR2 and MEK inhibitors in the treatment of FGFR2-amplified cancers of unkn...



Synergic activity of FGFR2 and MEK inhibitors in the treatment of FGFR2-amplified cancers of unknown primary  ScienceDirect.com

MEK inhibitor resistance in lung adenocarcinoma is associated with addiction to sustained ERK sup...



MEK inhibitor resistance in lung adenocarcinoma is associated with addiction to sustained ERK suppression  Nature

Meet Mek Thorpe, GARE Ambassador - California Department of Corrections and Rehabilitation (.gov)



Meet Mek Thorpe, GARE Ambassador  California Department of Corrections and Rehabilitation (.gov)

BRAF–MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas - NEJM



BRAF–MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas  NEJM

Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antib...



Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antibodies in tumor therapy  Nature

Mechanistic and Clinical Overview Cardiovascular Toxicity of BRAF and MEK Inhibitors: JACC: Cardi...



Mechanistic and Clinical Overview Cardiovascular Toxicity of BRAF and MEK Inhibitors: JACC: CardioOncology State-of-the-Art Review  JACC Journals

Cardiotoxicity of BRAF/MEK Inhibitors: A Longitudinal Study Incorporating Contemporary Definition...



Cardiotoxicity of BRAF/MEK Inhibitors: A Longitudinal Study Incorporating Contemporary Definitions and Risk Scores  JACC Journals

Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy - Nature



Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy  Nature

KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS - Scien...



KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS  ScienceDirect.com

Defectors Tell of Torture and Forced Sterilization in Militant Iranian Cult - The Intercept



Defectors Tell of Torture and Forced Sterilization in Militant Iranian Cult  The Intercept

Structural basis for the action of the drug trametinib at KSR-bound MEK - Nature



Structural basis for the action of the drug trametinib at KSR-bound MEK  Nature

The overview of Mitogen-activated extracellular signal-regulated kinase (MEK)-based dual inhibito...



The overview of Mitogen-activated extracellular signal-regulated kinase (MEK)-based dual inhibitor in the treatment of cancers  ScienceDirect.com

MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive G...



MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ  Nature

Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial | Nature M...



Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial | Nature Medicine  Nature

Exceptional Response to MEK Inhibition in a Patient With RAF1-Mutant Myxofibrosarcoma: Case Repor...



Exceptional Response to MEK Inhibition in a Patient With RAF1-Mutant Myxofibrosarcoma: Case Report and Mechanistic Overview  ASCO Publications

Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor pro...



Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor progression  Nature

Who is the Iranian group targeted by bombers and beloved of Trump allies? - The Guardian



Who is the Iranian group targeted by bombers and beloved of Trump allies?  The Guardian

PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK - ScienceDire...



PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK  ScienceDirect.com

Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-dri...



Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers  Nature

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage - Nature



Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage  Nature

MEK inhibition enhances the response to tyrosine kinase inhibitors in acute myeloid leukemia - Na...



MEK inhibition enhances the response to tyrosine kinase inhibitors in acute myeloid leukemia  Nature

Effect of NFX-179 MEK inhibitor on cutaneous neurofibromas in persons with neurofibromatosis type...



Effect of NFX-179 MEK inhibitor on cutaneous neurofibromas in persons with neurofibromatosis type 1  Science | AAAS

The CNK–HYP scaffolding complex promotes RAF activation by enhancing KSR–MEK interaction - Nature



The CNK–HYP scaffolding complex promotes RAF activation by enhancing KSR–MEK interaction  Nature

Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberran...



Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer  Nature

Global view of the RAF-MEK-ERK module and its immediate downstream effectors - Nature



Global view of the RAF-MEK-ERK module and its immediate downstream effectors  Nature

MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer - Nature



MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer  Nature

IL-1β-activated PI3K/AKT and MEK/ERK pathways coordinately promote induction of partial epithelia...



IL-1β-activated PI3K/AKT and MEK/ERK pathways coordinately promote induction of partial epithelial–mesenchymal transition  Cell Communication and Signaling

CDK4/6 inhibition sensitizes MEK inhibition by inhibiting cell cycle and proliferation in pancrea...



CDK4/6 inhibition sensitizes MEK inhibition by inhibiting cell cycle and proliferation in pancreatic ductal adenocarcinoma  Nature

Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Sig...



Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling  ScienceDirect.com

Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities ...



Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers  Science | AAAS

Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated ...



Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated Fibroblasts With Mesenchymal Stem Cell-Like Features to Overcome Immunotherapy Resistance in Pancreatic Cancer  ScienceDirect.com

Efficacy of MEK inhibition in patients with histiocytic neoplasms - Nature



Efficacy of MEK inhibition in patients with histiocytic neoplasms  Nature

Combined BRAF and MEK Inhibition versus BRAF Inhibition Alone in Melanoma - NEJM



Combined BRAF and MEK Inhibition versus BRAF Inhibition Alone in Melanoma  NEJM

Live-cell target engagement of allosteric MEKi on MEK–RAF/KSR–14-3-3 complexes - Nature



Live-cell target engagement of allosteric MEKi on MEK–RAF/KSR–14-3-3 complexes  Nature

Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors - ...



Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors  Nature

MEK inhibitors increase the mortality rate in mice with LPS-induced inflammation through IL-12-NO...



MEK inhibitors increase the mortality rate in mice with LPS-induced inflammation through IL-12-NO signaling  Nature

Simulating BRAFV600E-MEK-ERK signalling dynamics in response to vertical inhibition treatment str...



Simulating BRAFV600E-MEK-ERK signalling dynamics in response to vertical inhibition treatment strategies  Nature

Design, Synthesis, and Biological Evaluation of MEK PROTACs - ACS Publications



Design, Synthesis, and Biological Evaluation of MEK PROTACs  ACS Publications

Concurrent inhibition of pBADS99 synergistically improves MEK inhibitor efficacy in KRAS - Nature



Concurrent inhibition of pBADS99 synergistically improves MEK inhibitor efficacy in KRAS  Nature

Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases - ...



Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases  Nature

Iran: The MEK in Albania - National Council of Resistance of Iran - NCRI



Iran: The MEK in Albania  National Council of Resistance of Iran - NCRI

The limitations of targeting MEK signalling in Glioblastoma therapy - Nature



The limitations of targeting MEK signalling in Glioblastoma therapy  Nature

Former MEK leader Massoud Rajavi died under US guard, say Iran media - Al Jazeera



Former MEK leader Massoud Rajavi died under US guard, say Iran media  Al Jazeera

Targeting mTOR signaling overcomes acquired resistance to combined BRAF and MEK inhibition in BRA...



Targeting mTOR signaling overcomes acquired resistance to combined BRAF and MEK inhibition in BRAF -mutant melanoma  Nature

Evidence for an Oceanic Source of Methyl Ethyl Ketone to the Atmosphere - AGU Publications



Evidence for an Oceanic Source of Methyl Ethyl Ketone to the Atmosphere  AGU Publications

Characterization of two melanoma cell lines resistant to BRAF/MEK inhibitors (vemurafenib and cob...



Characterization of two melanoma cell lines resistant to BRAF/MEK inhibitors (vemurafenib and cobimetinib)  Cell Communication and Signaling

Immunomodulatory effects of BRAF and MEK inhibitors: Implications for Melanoma therapy - ScienceD...



Immunomodulatory effects of BRAF and MEK inhibitors: Implications for Melanoma therapy  ScienceDirect.com

Robustness of MEK-ERK Dynamics and Origins of Cell-to-Cell Variability in MAPK Signaling - Scienc...



Robustness of MEK-ERK Dynamics and Origins of Cell-to-Cell Variability in MAPK Signaling  ScienceDirect.com

Differential effects of MEK inhibitors on rat neural stem cell differentiation: Repressive roles ...



Differential effects of MEK inhibitors on rat neural stem cell differentiation: Repressive roles of MEK2 in neurogenesis and induction of astrocytogenesis by PD98059  ScienceDirect.com