"MEK" の関連情報検索結果
Coinhibition of the MEK/RTK pathway has high therapeutic efficacy in KRAS-mutant non-small cell l...

Basroparib overcomes acquired resistance to MEK inhibitors by inhibiting Wnt-mediated cancer stem...

Basroparib overcomes acquired resistance to MEK inhibitors by inhibiting Wnt-mediated cancer stemness in KRAS-mutated colorectal cancer ScienceDirect.com
Free Iran 2025– Maryam Rajavi’s Remarks on the MEK’s 60th Anniversary - National Council of Resis...

Free Iran 2025– Maryam Rajavi’s Remarks on the MEK’s 60th Anniversary National Council of Resistance of Iran - NCRI
Impact of MEK Inhibition on Childhood RASopathy-Associated Hypertrophic Cardiomyopathy - JACC Jou...

Impact of MEK Inhibition on Childhood RASopathy-Associated Hypertrophic Cardiomyopathy JACC Journals
The role of MEK inhibition in pediatric low-grade gliomas - Frontiers

The role of MEK inhibition in pediatric low-grade gliomas Frontiers
Dr Moertel on the Importance of Managing MEK Inhibitor–Associated Toxicites in NF1-Associated PN ...

Dr Moertel on the Importance of Managing MEK Inhibitor–Associated Toxicites in NF1-Associated PN OncLive
Blocking Nitrosylation Boosts MEK Inhibitors in Aggressive Melanoma - Targeted Oncology

Blocking Nitrosylation Boosts MEK Inhibitors in Aggressive Melanoma Targeted Oncology
Cx43 enhances response to BRAF/MEK inhibitors by reducing DNA repair capacity - Nature

Cx43 enhances response to BRAF/MEK inhibitors by reducing DNA repair capacity Nature
DCP1A, a MEK substrate, regulates the self-renewal and differentiation of mouse embryonic stem ce...

DCP1A, a MEK substrate, regulates the self-renewal and differentiation of mouse embryonic stem cells ScienceDirect.com
Efficacy of MEK inhibitors in Erdheim-Chester disease: impact of MAPK pathway pathogenic variants...

FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and ...

FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma ScienceDirect.com
The MEK inhibitor trametinib is effective in inhibiting the growth of canine oral squamous cell c...

BRAF/MEK inhibition induces cell state transitions boosting immune checkpoint sensitivity in BRAF...

BRAF/MEK inhibition induces cell state transitions boosting immune checkpoint sensitivity in BRAF ScienceDirect.com
MEK inhibitors are effective in Erdheim–Chester disease regardless of MAPK pathway mutations | Le...

Novel high throughput 3D ECM remodeling assay identifies MEK as key driver of fibrotic fibroblast...

Novel high throughput 3D ECM remodeling assay identifies MEK as key driver of fibrotic fibroblast activity ScienceDirect.com
Case report: Successful use of MEK inhibitors as an adjuvant approach in the treatment of pediatr...

Heme promotes venetoclax resistance in multiple myeloma through MEK-ERK signaling and purine bios...

Heme promotes venetoclax resistance in multiple myeloma through MEK-ERK signaling and purine biosynthesis ScienceDirect.com
Targeting gut microbiota and arginase boosts MEK inhibitors’ enhancement of antitumour immunity v...

MEK inhibition prevents human skin graft rejection by promoting CD8+TCF1+ over CD8 effector T cel...

MEK inhibition prevents human skin graft rejection by promoting CD8+TCF1+ over CD8 effector T cells ScienceDirect.com
Concurrent SOS1 and MEK suppression inhibits signaling and growth of NF1-null melanoma - ScienceD...

Concurrent SOS1 and MEK suppression inhibits signaling and growth of NF1-null melanoma ScienceDirect.com
Fifth International Diada Castellera: A Human Tower Will Be Built at the MEK on 3 May 2025 - Staa...

Fifth International Diada Castellera: A Human Tower Will Be Built at the MEK on 3 May 2025 Staatliche Museen zu Berlin
Toluene, styrene and methyl-ethyl-ketone inhalation: Effects on the power of cortical oscillation...

Toluene, styrene and methyl-ethyl-ketone inhalation: Effects on the power of cortical oscillations in rats ScienceDirect.com
ELABELA targets the MEK/ERK axis to enhance trophoblast invasion in early-onset preeclampsia - Na...

ELABELA targets the MEK/ERK axis to enhance trophoblast invasion in early-onset preeclampsia Nature
Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melano...

Combined inhibition of focal adhesion kinase and RAF/MEK elicits synergistic inhibition of melanoma growth and reduces metastases ScienceDirect.com
Adjuvant BRAF/MEK versus anti-PD-1 in BRAF-mutant melanoma: a propensity score matched survival a...

The clinically relevant MEK inhibitor mirdametinib combined with D-cycloserine and prediction err...

Effective Toxicity Management is Key to Maximizing Benefit With MEK Inhibitors in NF1-Associated ...

Effective Toxicity Management is Key to Maximizing Benefit With MEK Inhibitors in NF1-Associated PN OncLive
KOMET in the landscape of MEK inhibitor clinical trials for plexiform neurofibromas - The Lancet

KOMET in the landscape of MEK inhibitor clinical trials for plexiform neurofibromas The Lancet
mutation treated with BRAF/MEK-targeted therapy plus cetuximab: A case report - Baishideng Publis...

mutation treated with BRAF/MEK-targeted therapy plus cetuximab: A case report Baishideng Publishing Group
MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and...

Impact of MEK Inhibition on Childhood RASopathy-Associated Hypertrophic Cardiomyopathy - JACC Jou...

Impact of MEK Inhibition on Childhood RASopathy-Associated Hypertrophic Cardiomyopathy JACC Journals
Global trends and emerging insights in BRAF and MEK inhibitor resistance in melanoma: a bibliomet...

Overcoming melanoma therapy resistance with RAF-MEK and FAK inhibition - ScienceDirect.com

Overcoming melanoma therapy resistance with RAF-MEK and FAK inhibition ScienceDirect.com
Molecular profiling is critical to guide MEK inhibitor use in Erdheim-Chester disease | Leukemia ...

Molecular profiling is critical to guide MEK inhibitor use in Erdheim-Chester disease | Leukemia Nature
Cutaneous adverse events associated with BRAF and MEK inhibitors: a systematic review and meta-an...

Extension for the Project on the Sámi Collection at MEK until November 2025 - Staatliche Museen z...

Extension for the Project on the Sámi Collection at MEK until November 2025 Staatliche Museen zu Berlin
A novel therapeutic strategy for leukopenia: Miltefosine activates the Ras/MEK/ERK pathway to pro...

A novel therapeutic strategy for leukopenia: Miltefosine activates the Ras/MEK/ERK pathway to promote neutrophil differentiation ScienceDirect.com
Combustion reaction mechanisms of methyl ethyl ketone peroxide (MEKPO) via the integration of Rea...

Combustion reaction mechanisms of methyl ethyl ketone peroxide (MEKPO) via the integration of ReaxFF-MD and DFT ScienceDirect.com
MEK inhibitors in maintenance of a postoperative patient with vasculopathy due to neurofibromatos...

MEK inhibitors in maintenance of a postoperative patient with vasculopathy due to neurofibromatosis type I SciELO México
Mujahedin-e Khalq (MEK) - The People's Mojahedin Organization of Iran (PMOI) - National Council o...

Mujahedin-e Khalq (MEK) - The People's Mojahedin Organization of Iran (PMOI) National Council of Resistance of Iran - NCRI
Cardiotoxicity of BRAF/MEK Inhibitors Mimicking Apical Hypertrophic Cardiomyopathy - Cureus

Cardiotoxicity of BRAF/MEK Inhibitors Mimicking Apical Hypertrophic Cardiomyopathy Cureus
MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells - Scien...

MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells ScienceDirect.com
The Trace of Maryam Rajavi in an Internal Tragedy of the MEK / What Do the MEK Do with Their Corp...

Terrorists, cultists – or champions of Iranian democracy? The wild wild story of the MEK - The Gu...

Terrorists, cultists – or champions of Iranian democracy? The wild wild story of the MEK The Guardian
Mujahadeen-e-Khalq (MEK) - Council on Foreign Relations

Mujahadeen-e-Khalq (MEK) Council on Foreign Relations
Treatment decisions and the use of MEK inhibitors for children with neurofibromatosis type 1-rela...

MEK inhibitors: a promising targeted therapy for cardiovascular disease - Frontiers

MEK inhibitors: a promising targeted therapy for cardiovascular disease Frontiers
MEK inhibitors for the treatment of non-small cell lung cancer - Journal of Hematology & Oncology

MEK inhibitors for the treatment of non-small cell lung cancer Journal of Hematology & Oncology
Optimizing photoswitchable MEK - PNAS

T lymphocytes into memory stem cells with potent antitumor effects - Nature

T lymphocytes into memory stem cells with potent antitumor effects Nature
Fine-tuning of MEK signaling is pivotal for limiting B and T cell activation - ScienceDirect.com

Fine-tuning of MEK signaling is pivotal for limiting B and T cell activation ScienceDirect.com
Synergic activity of FGFR2 and MEK inhibitors in the treatment of FGFR2-amplified cancers of unkn...

Synergic activity of FGFR2 and MEK inhibitors in the treatment of FGFR2-amplified cancers of unknown primary ScienceDirect.com
MEK inhibitor resistance in lung adenocarcinoma is associated with addiction to sustained ERK sup...

Meet Mek Thorpe, GARE Ambassador - California Department of Corrections and Rehabilitation (.gov)

Meet Mek Thorpe, GARE Ambassador California Department of Corrections and Rehabilitation (.gov)
BRAF–MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas - NEJM

BRAF–MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas NEJM
Proimmunogenic impact of MEK inhibition synergizes with agonist anti-CD40 immunostimulatory antib...

Mechanistic and Clinical Overview Cardiovascular Toxicity of BRAF and MEK Inhibitors: JACC: Cardi...

Cardiotoxicity of BRAF/MEK Inhibitors: A Longitudinal Study Incorporating Contemporary Definition...

Cardiotoxicity of BRAF/MEK Inhibitors: A Longitudinal Study Incorporating Contemporary Definitions and Risk Scores JACC Journals
Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy - Nature

Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy Nature
KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS - Scien...

KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS ScienceDirect.com
Defectors Tell of Torture and Forced Sterilization in Militant Iranian Cult - The Intercept

Defectors Tell of Torture and Forced Sterilization in Militant Iranian Cult The Intercept
Structural basis for the action of the drug trametinib at KSR-bound MEK - Nature

Structural basis for the action of the drug trametinib at KSR-bound MEK Nature
The overview of Mitogen-activated extracellular signal-regulated kinase (MEK)-based dual inhibito...

The overview of Mitogen-activated extracellular signal-regulated kinase (MEK)-based dual inhibitor in the treatment of cancers ScienceDirect.com
MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive G...

MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ Nature
Combined PD-1, BRAF and MEK inhibition in BRAFV600E colorectal cancer: a phase 2 trial | Nature M...

Exceptional Response to MEK Inhibition in a Patient With RAF1-Mutant Myxofibrosarcoma: Case Repor...

Exceptional Response to MEK Inhibition in a Patient With RAF1-Mutant Myxofibrosarcoma: Case Report and Mechanistic Overview ASCO Publications
Combined MEK and JAK/STAT3 pathway inhibition effectively decreases SHH medulloblastoma tumor pro...

Who is the Iranian group targeted by bombers and beloved of Trump allies? - The Guardian

Who is the Iranian group targeted by bombers and beloved of Trump allies? The Guardian
PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK - ScienceDire...

PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK ScienceDirect.com
Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-dri...

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage - Nature

Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage Nature
MEK inhibition enhances the response to tyrosine kinase inhibitors in acute myeloid leukemia - Na...

MEK inhibition enhances the response to tyrosine kinase inhibitors in acute myeloid leukemia Nature
Effect of NFX-179 MEK inhibitor on cutaneous neurofibromas in persons with neurofibromatosis type...

Effect of NFX-179 MEK inhibitor on cutaneous neurofibromas in persons with neurofibromatosis type 1 Science | AAAS
The CNK–HYP scaffolding complex promotes RAF activation by enhancing KSR–MEK interaction - Nature

The CNK–HYP scaffolding complex promotes RAF activation by enhancing KSR–MEK interaction Nature
Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberran...

Global view of the RAF-MEK-ERK module and its immediate downstream effectors - Nature

Global view of the RAF-MEK-ERK module and its immediate downstream effectors Nature
MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer - Nature

MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer Nature
IL-1β-activated PI3K/AKT and MEK/ERK pathways coordinately promote induction of partial epithelia...

IL-1β-activated PI3K/AKT and MEK/ERK pathways coordinately promote induction of partial epithelial–mesenchymal transition Cell Communication and Signaling
CDK4/6 inhibition sensitizes MEK inhibition by inhibiting cell cycle and proliferation in pancrea...

Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Sig...

Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling ScienceDirect.com
Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities ...

Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers Science | AAAS
Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated ...

Efficacy of MEK inhibition in patients with histiocytic neoplasms - Nature

Efficacy of MEK inhibition in patients with histiocytic neoplasms Nature
Combined BRAF and MEK Inhibition versus BRAF Inhibition Alone in Melanoma - NEJM

Combined BRAF and MEK Inhibition versus BRAF Inhibition Alone in Melanoma NEJM
Live-cell target engagement of allosteric MEKi on MEK–RAF/KSR–14-3-3 complexes - Nature

Live-cell target engagement of allosteric MEKi on MEK–RAF/KSR–14-3-3 complexes Nature
Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors - ...

Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors Nature
MEK inhibitors increase the mortality rate in mice with LPS-induced inflammation through IL-12-NO...

Simulating BRAFV600E-MEK-ERK signalling dynamics in response to vertical inhibition treatment str...

Design, Synthesis, and Biological Evaluation of MEK PROTACs - ACS Publications

Design, Synthesis, and Biological Evaluation of MEK PROTACs ACS Publications
Concurrent inhibition of pBADS99 synergistically improves MEK inhibitor efficacy in KRAS - Nature

Concurrent inhibition of pBADS99 synergistically improves MEK inhibitor efficacy in KRAS Nature
Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases - ...

Intrinsically active MEK variants are differentially regulated by proteinases and phosphatases Nature
Iran: The MEK in Albania - National Council of Resistance of Iran - NCRI

Iran: The MEK in Albania National Council of Resistance of Iran - NCRI
The limitations of targeting MEK signalling in Glioblastoma therapy - Nature

The limitations of targeting MEK signalling in Glioblastoma therapy Nature
Former MEK leader Massoud Rajavi died under US guard, say Iran media - Al Jazeera

Former MEK leader Massoud Rajavi died under US guard, say Iran media Al Jazeera
Targeting mTOR signaling overcomes acquired resistance to combined BRAF and MEK inhibition in BRA...

Evidence for an Oceanic Source of Methyl Ethyl Ketone to the Atmosphere - AGU Publications

Evidence for an Oceanic Source of Methyl Ethyl Ketone to the Atmosphere AGU Publications
Characterization of two melanoma cell lines resistant to BRAF/MEK inhibitors (vemurafenib and cob...

Characterization of two melanoma cell lines resistant to BRAF/MEK inhibitors (vemurafenib and cobimetinib) Cell Communication and Signaling
Immunomodulatory effects of BRAF and MEK inhibitors: Implications for Melanoma therapy - ScienceD...

Immunomodulatory effects of BRAF and MEK inhibitors: Implications for Melanoma therapy ScienceDirect.com
Robustness of MEK-ERK Dynamics and Origins of Cell-to-Cell Variability in MAPK Signaling - Scienc...

Robustness of MEK-ERK Dynamics and Origins of Cell-to-Cell Variability in MAPK Signaling ScienceDirect.com
Differential effects of MEK inhibitors on rat neural stem cell differentiation: Repressive roles ...
