NSMB’s 30th anniversary: shining a light on the invisible - Nature

NSMB’s 30th anniversary: shining a light on the invisible  Nature

Why New Super Mario Bros. 2 Cannot Rest on the Original's Laurels - Nintendo World Report

Why New Super Mario Bros. 2 Cannot Rest on the Original's Laurels  Nintendo World Report

New Super Mario Bros. 2 review for 3DS - Gaming Age

New Super Mario Bros. 2 review for 3DS  Gaming Age

Structural basis for excitatory neuropeptide signaling - Nature

Structural basis for excitatory neuropeptide signaling  Nature

Uncovering global SUMOylation signaling networks in a site-specific manner - Nature

Uncovering global SUMOylation signaling networks in a site-specific manner  Nature

An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem ...

An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells  Nature

A rule of seven in Watson-Crick base-pairing of mismatched sequences - Nature

A rule of seven in Watson-Crick base-pairing of mismatched sequences  Nature

A family of macrodomain proteins reverses cellular mono-ADP-ribosylation - Nature

A family of macrodomain proteins reverses cellular mono-ADP-ribosylation  Nature

Cryo-electron microscopy structure of the TRPV2 ion channel - Nature

Cryo-electron microscopy structure of the TRPV2 ion channel  Nature

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A ...

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses  Nature

The N domain of Argonaute drives duplex unwinding during RISC assembly - Nature

The N domain of Argonaute drives duplex unwinding during RISC assembly  Nature

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers - Nature

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers  Nature

Sequence-specific regulator Prdm14 safeguards mouse ESCs from entering extraembryonic endoderm fa...

Sequence-specific regulator Prdm14 safeguards mouse ESCs from entering extraembryonic endoderm fates  Nature

Structural basis of substrate recognition and specificity in the N-end rule pathway - Nature

Structural basis of substrate recognition and specificity in the N-end rule pathway  Nature

Fluorescent fusion protein knockout mediated by anti-GFP nanobody - Nature

Fluorescent fusion protein knockout mediated by anti-GFP nanobody  Nature

RdRP-synthesized antisense ribosomal siRNAs silence pre-rRNA via the nuclear RNAi pathway - Nature

RdRP-synthesized antisense ribosomal siRNAs silence pre-rRNA via the nuclear RNAi pathway  Nature

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site - Nature

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site  Nature

LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis eleg...

LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans  Nature

A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein - Nature

A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein  Nature

Recognition of microbial glycans by human intelectin-1 - Nature

Recognition of microbial glycans by human intelectin-1  Nature

Structural dynamics of potassium-channel gating revealed by single-molecule FRET - Nature

Structural dynamics of potassium-channel gating revealed by single-molecule FRET  Nature

Assembly, analysis and architecture of atypical ubiquitin chains - Nature

Assembly, analysis and architecture of atypical ubiquitin chains  Nature

The program for processing newly synthesized histones H3.1 and H4 - Nature

The program for processing newly synthesized histones H3.1 and H4  Nature

Structurally encoded intraclass differences in EphA clusters drive distinct cell responses - Nature

Structurally encoded intraclass differences in EphA clusters drive distinct cell responses  Nature

The E3 ligase RNF8 regulates KU80 removal and NHEJ repair - Nature

The E3 ligase RNF8 regulates KU80 removal and NHEJ repair  Nature

Prereplication-complex formation: a molecular double take? - Nature

Prereplication-complex formation: a molecular double take?  Nature

Privateer: software for the conformational validation of carbohydrate structures - Nature

Privateer: software for the conformational validation of carbohydrate structures  Nature

The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1A - Na...

The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1A  Nature

MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD - Nature

MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD  Nature

An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse...

An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3  Nature

Transcription-dependent dynamic supercoiling is a short-range genomic force - Nature

Transcription-dependent dynamic supercoiling is a short-range genomic force  Nature

Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin main...

Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance  Nature

A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome -...

A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome  Nature

A specialized molecular motion opens the Hv1 voltage-gated proton channel - Nature

A specialized molecular motion opens the Hv1 voltage-gated proton channel  Nature

The evolutionary journey of Argonaute proteins - Nature

The evolutionary journey of Argonaute proteins  Nature

Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export com...

Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex  Nature

The RNA exosome promotes transcription termination of backtracked RNA polymerase II - Nature

The RNA exosome promotes transcription termination of backtracked RNA polymerase II  Nature

Nucleosome assembly is required for nuclear pore complex assembly in mouse zygotes - Nature

Nucleosome assembly is required for nuclear pore complex assembly in mouse zygotes  Nature

New Super Mario Bros. U Hands-on Preview - Hands-on Preview - Nintendo World Report

New Super Mario Bros. U Hands-on Preview - Hands-on Preview  Nintendo World Report

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A - Nature

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A  Nature

Mechanism of activation of bacterial cellulose synthase by cyclic di-GMP - Nature

Mechanism of activation of bacterial cellulose synthase by cyclic di-GMP  Nature

Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases - Nature

Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases  Nature

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab - Nature

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab  Nature

Technologies to probe functions and mechanisms of long noncoding RNAs - Nature

Technologies to probe functions and mechanisms of long noncoding RNAs  Nature

New Super Mario Bros. Wii review: impressive, and then some - Ars Technica

New Super Mario Bros. Wii review: impressive, and then some  Ars Technica

Solo or doppio: how many CENP-As make a centromeric nucleosome? - Nature

Solo or doppio: how many CENP-As make a centromeric nucleosome?  Nature

Replication stress: getting back on track - Nature

Replication stress: getting back on track  Nature

A distinct mechanism for the ABC transporter BtuCD–BtuF revealed by the dynamics of complex forma...

A distinct mechanism for the ABC transporter BtuCD–BtuF revealed by the dynamics of complex formation  Nature

More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules - ...

More-powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules  Nature

DNA secondary structures and epigenetic determinants of cancer genome evolution - Nature

DNA secondary structures and epigenetic determinants of cancer genome evolution  Nature

The active site of O-GlcNAc transferase imposes constraints on substrate sequence - Nature

The active site of O-GlcNAc transferase imposes constraints on substrate sequence  Nature

Centromere chromatin: a loose grip on the nucleosome? - Nature

Centromere chromatin: a loose grip on the nucleosome?  Nature

A complex network of factors with overlapping affinities represses splicing through intronic elem...

A complex network of factors with overlapping affinities represses splicing through intronic elements  Nature

Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasome...

Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes  Nature

Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy - Nature

Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy  Nature

New Super Mario Bros. U Deluxe Review - TheSixthAxis

New Super Mario Bros. U Deluxe Review  TheSixthAxis

HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin - ...

HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin  Nature

Transient ribosomal attenuation coordinates protein synthesis and co-translational folding - Nature

Transient ribosomal attenuation coordinates protein synthesis and co-translational folding  Nature

Structural basis of respiratory syncytial virus neutralization by motavizumab - Nature

Structural basis of respiratory syncytial virus neutralization by motavizumab  Nature

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair - Nature

Human DNA polymerase θ grasps the primer terminus to mediate DNA repair  Nature

X-ray crystal structure of voltage-gated proton channel - Nature

X-ray crystal structure of voltage-gated proton channel  Nature

Structural snapshot of cytoplasmic pre-60S ribosomal particles bound by Nmd3, Lsg1, Tif6 and Reh1...

Structural snapshot of cytoplasmic pre-60S ribosomal particles bound by Nmd3, Lsg1, Tif6 and Reh1  Nature

Complex interactions between the DNA-damage response and mammalian telomeres - Nature

Complex interactions between the DNA-damage response and mammalian telomeres  Nature

Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by th...

Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne  Nature

A conserved activation element in BMP signaling during Drosophila development - Nature

A conserved activation element in BMP signaling during Drosophila development  Nature

Site-resolved measurement of water-protein interactions by solution NMR - Nature

Site-resolved measurement of water-protein interactions by solution NMR  Nature

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation - Nature

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation  Nature

Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptor - Nature

Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptor  Nature

Intrinsic histone-DNA interactions are not the major determinant of nucleosome positions in vivo ...

Intrinsic histone-DNA interactions are not the major determinant of nucleosome positions in vivo  Nature

NMR Exchange Format: a unified and open standard for representation of NMR restraint data - Nature

NMR Exchange Format: a unified and open standard for representation of NMR restraint data  Nature

The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing ...

The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex  Nature

Bimodal expression of PHO84 is modulated by early termination of antisense transcription - Nature

Bimodal expression of PHO84 is modulated by early termination of antisense transcription  Nature

Structure of the retinoid X receptor α–liver X receptor β (RXRα–LXRβ) heterodimer on DNA - Nature

Structure of the retinoid X receptor α–liver X receptor β (RXRα–LXRβ) heterodimer on DNA  Nature

Expanding the RNA-recognition code of PUF proteins - Nature

Expanding the RNA-recognition code of PUF proteins  Nature

Mechanism of potassium-channel selectivity revealed by Na - Nature

Mechanism of potassium-channel selectivity revealed by Na  Nature

Review - New Super Mario Bros 2 Co-Op Review - Co-Optimus

Review - New Super Mario Bros 2 Co-Op Review  Co-Optimus

Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2 - Nature

Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2  Nature

A timer to coordinate substrate processing by the 26S proteasome - Nature

A timer to coordinate substrate processing by the 26S proteasome  Nature

A route to new cancer therapies: the FA pathway is essential in BRCA1- or BRCA2-deficient cells -...

A route to new cancer therapies: the FA pathway is essential in BRCA1- or BRCA2-deficient cells  Nature

Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs - Nature

Structural basis of G-tract recognition and encaging by hnRNP F quasi-RRMs  Nature

The microtubule-associated tau protein has intrinsic acetyltransferase activity - Nature

The microtubule-associated tau protein has intrinsic acetyltransferase activity  Nature

A team effort blocks the ribosome in its tracks - Nature

A team effort blocks the ribosome in its tracks  Nature

Two-step adhesive binding by classical cadherins - Nature

Two-step adhesive binding by classical cadherins  Nature

Friedreich's ataxia–associated GAA repeats induce replication-fork reversal and unusual molecular...

Friedreich's ataxia–associated GAA repeats induce replication-fork reversal and unusual molecular junctions  Nature

Nectin ectodomain structures reveal a canonical adhesive interface - Nature

Nectin ectodomain structures reveal a canonical adhesive interface  Nature

Plasmepsin V shows its carnivorous side - Nature

Plasmepsin V shows its carnivorous side  Nature

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling - Nature

STAT2 is an essential adaptor in USP18-mediated suppression of type I interferon signaling  Nature

NMR disentangles a dynamic disaggregase machinery - Nature

NMR disentangles a dynamic disaggregase machinery  Nature

The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks - Nature

The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks  Nature

Mechanisms for U2AF to define 3′ splice sites and regulate alternative splicing in the human geno...

Mechanisms for U2AF to define 3′ splice sites and regulate alternative splicing in the human genome  Nature

ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4 - Nature

ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4  Nature

The Microprocessor controls the activity of mammalian retrotransposons - Nature

The Microprocessor controls the activity of mammalian retrotransposons  Nature

DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage - Nature

DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage  Nature

Structure of the Atg101–Atg13 complex reveals essential roles of Atg101 in autophagy initiation -...

Structure of the Atg101–Atg13 complex reveals essential roles of Atg101 in autophagy initiation  Nature

Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures - ...

Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures  Nature

Structural insights into human KAP1 PHD finger–bromodomain and its role in gene silencing - Nature

Structural insights into human KAP1 PHD finger–bromodomain and its role in gene silencing  Nature

Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation - Nature

Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation  Nature

Mapping the sequence of conformational changes underlying selectivity filter gating in the K - Na...

Mapping the sequence of conformational changes underlying selectivity filter gating in the K  Nature

Structural and biochemical studies of the 5′→3′ exoribonuclease Xrn1 - Nature

Structural and biochemical studies of the 5′→3′ exoribonuclease Xrn1  Nature

Cryo-EM structure of the mature dengue virus at 3.5-Å resolution - Nature

Cryo-EM structure of the mature dengue virus at 3.5-Å resolution  Nature