New Super Mario Bros Wii speedrunner gets AGDQ's standing ovation by playing the entire soundtrac...

New Super Mario Bros Wii speedrunner gets AGDQ's standing ovation by playing the entire soundtrack on piano while beating the game with controllers strapped to his body  GamesRadar+

NSMB’s 30th anniversary: shining a light on the invisible - Nature

NSMB’s 30th anniversary: shining a light on the invisible  Nature

New Super Mario Bros.™ U Deluxe - Nintendo

New Super Mario Bros.™ U Deluxe  Nintendo

...what actually happened at the 2012 NSMB The AIR-prentice? - Pinkbike

...what actually happened at the 2012 NSMB The AIR-prentice?  Pinkbike

Why New Super Mario Bros. 2 Cannot Rest on the Original's Laurels - Nintendo World Report

Why New Super Mario Bros. 2 Cannot Rest on the Original's Laurels  Nintendo World Report

Structural basis for excitatory neuropeptide signaling - Nature

Structural basis for excitatory neuropeptide signaling  Nature

Structural basis of the specificity of USP18 toward ISG15 - Nature

Structural basis of the specificity of USP18 toward ISG15  Nature

Cryo-electron microscopy structure of the TRPV2 ion channel - Nature

Cryo-electron microscopy structure of the TRPV2 ion channel  Nature

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A ...

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses  Nature

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers - Nature

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers  Nature

A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein - Nature

A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein  Nature

Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit...

Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit  Nature

RdRP-synthesized antisense ribosomal siRNAs silence pre-rRNA via the nuclear RNAi pathway - Nature

RdRP-synthesized antisense ribosomal siRNAs silence pre-rRNA via the nuclear RNAi pathway  Nature

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site - Nature

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site  Nature

Recognition of microbial glycans by human intelectin-1 - Nature

Recognition of microbial glycans by human intelectin-1  Nature

Atomic model of a nonenveloped virus reveals pH sensors for a coordinated process of cell entry -...

Atomic model of a nonenveloped virus reveals pH sensors for a coordinated process of cell entry  Nature

The energy landscape of adenylate kinase during catalysis - Nature

The energy landscape of adenylate kinase during catalysis  Nature

Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export com...

Structural basis for the assembly and nucleic acid binding of the TREX-2 transcription-export complex  Nature

Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase REC...

Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5  Nature

A family of macrodomain proteins reverses cellular mono-ADP-ribosylation - Nature

A family of macrodomain proteins reverses cellular mono-ADP-ribosylation  Nature

Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation ...

Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation  Nature

The E3 ligase RNF8 regulates KU80 removal and NHEJ repair - Nature

The E3 ligase RNF8 regulates KU80 removal and NHEJ repair  Nature

MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria - Nature

MIA40 is an oxidoreductase that catalyzes oxidative protein folding in mitochondria  Nature

The evolutionary journey of Argonaute proteins - Nature

The evolutionary journey of Argonaute proteins  Nature

MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD - Nature

MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD  Nature

Fluorescent fusion protein knockout mediated by anti-GFP nanobody - Nature

Fluorescent fusion protein knockout mediated by anti-GFP nanobody  Nature

Assembly, analysis and architecture of atypical ubiquitin chains - Nature

Assembly, analysis and architecture of atypical ubiquitin chains  Nature

Structure of a kinesin–tubulin complex and implications for kinesin motility - Nature

Structure of a kinesin–tubulin complex and implications for kinesin motility  Nature

The histone methyltransferase MLL1 permits the oscillation of circadian gene expression - Nature

The histone methyltransferase MLL1 permits the oscillation of circadian gene expression  Nature

Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin main...

Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance  Nature

New Super Mario Bros. U Hands-on Preview - Hands-on Preview - Nintendo World Report

New Super Mario Bros. U Hands-on Preview - Hands-on Preview  Nintendo World Report

Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pne...

Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site  Nature

Solo or doppio: how many CENP-As make a centromeric nucleosome? - Nature

Solo or doppio: how many CENP-As make a centromeric nucleosome?  Nature

PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells - Nature

PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells  Nature

The RNA exosome promotes transcription termination of backtracked RNA polymerase II - Nature

The RNA exosome promotes transcription termination of backtracked RNA polymerase II  Nature

Structural aspects of messenger RNA reading frame maintenance by the ribosome - Nature

Structural aspects of messenger RNA reading frame maintenance by the ribosome  Nature

'New Super Mario Bros. U Deluxe' is the best game I've ever despised - Mashable

'New Super Mario Bros. U Deluxe' is the best game I've ever despised  Mashable

Structure of the Atg101–Atg13 complex reveals essential roles of Atg101 in autophagy initiation -...

Structure of the Atg101–Atg13 complex reveals essential roles of Atg101 in autophagy initiation  Nature

Notch is a direct negative regulator of the DNA-damage response - Nature

Notch is a direct negative regulator of the DNA-damage response  Nature

Transcriptional regulation by Polycomb group proteins - Nature

Transcriptional regulation by Polycomb group proteins  Nature

X-ray crystal structure of voltage-gated proton channel - Nature

X-ray crystal structure of voltage-gated proton channel  Nature

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A - Nature

N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A  Nature

A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly - Nature

A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly  Nature

An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem ...

An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells  Nature

Cotranscriptional exon skipping in the genotoxic stress response - Nature

Cotranscriptional exon skipping in the genotoxic stress response  Nature

An Untimely Review of the Now Not So New Super Mario Bros. - VentureBeat

An Untimely Review of the Now Not So New Super Mario Bros.  VentureBeat

The structural basis of direct glucocorticoid-mediated transrepression - Nature

The structural basis of direct glucocorticoid-mediated transrepression  Nature

Intrinsic tethering activity of endosomal Rab proteins - Nature

Intrinsic tethering activity of endosomal Rab proteins  Nature

Site-resolved measurement of water-protein interactions by solution NMR - Nature

Site-resolved measurement of water-protein interactions by solution NMR  Nature

A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome -...

A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome  Nature

Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfe...

Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer  Nature

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90 - Nature

Dissection of the ATP-induced conformational cycle of the molecular chaperone Hsp90  Nature

ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4 - Nature

ERK1 and ERK2 regulate embryonic stem cell self-renewal through phosphorylation of Klf4  Nature

Privateer: software for the conformational validation of carbohydrate structures - Nature

Privateer: software for the conformational validation of carbohydrate structures  Nature

A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization...

A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization  Nature

Real-time assembly landscape of bacterial 30S translation initiation complex - Nature

Real-time assembly landscape of bacterial 30S translation initiation complex  Nature

Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation - Nature

Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation  Nature

NMR Exchange Format: a unified and open standard for representation of NMR restraint data - Nature

NMR Exchange Format: a unified and open standard for representation of NMR restraint data  Nature

Technologies to probe functions and mechanisms of long noncoding RNAs - Nature

Technologies to probe functions and mechanisms of long noncoding RNAs  Nature

E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1 - Nature

E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1  Nature

Decapping is preceded by 3′ uridylation in a novel pathway of bulk mRNA turnover - Nature

Decapping is preceded by 3′ uridylation in a novel pathway of bulk mRNA turnover  Nature

Mapping the sequence of conformational changes underlying selectivity filter gating in the K - Na...

Mapping the sequence of conformational changes underlying selectivity filter gating in the K  Nature

The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing ...

The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex  Nature

An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse...

An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3  Nature

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA - Nature

Human BRCA2 protein promotes RAD51 filament formation on RPA-covered single-stranded DNA  Nature

HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin - ...

HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin  Nature

PTEN is a protein tyrosine phosphatase for IRS1 - Nature

PTEN is a protein tyrosine phosphatase for IRS1  Nature

A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming - Nature

A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming  Nature

Topoisomerase I poisoning results in PARP-mediated replication fork reversal - Nature

Topoisomerase I poisoning results in PARP-mediated replication fork reversal  Nature

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation - Nature

A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation  Nature

Molecular mechanisms for protein-encoded inheritance - Nature

Molecular mechanisms for protein-encoded inheritance  Nature

Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis - Nature

Structure of collagenase G reveals a chew-and-digest mechanism of bacterial collagenolysis  Nature

Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function - N...

Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function  Nature

The structural basis for specific decoding of AUA by isoleucine tRNA on the ribosome - Nature

The structural basis for specific decoding of AUA by isoleucine tRNA on the ribosome  Nature

Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasome...

Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes  Nature

DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex - Nature

DNA binding alters coactivator interaction surfaces of the intact VDR–RXR complex  Nature

Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair - Nature

Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair  Nature

Structure of the cholera toxin secretion channel in its closed state - Nature

Structure of the cholera toxin secretion channel in its closed state  Nature

The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1A - Na...

The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1A  Nature

Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy - Nature

Structure of the human ATG12~ATG5 conjugate required for LC3 lipidation in autophagy  Nature

Nectin ectodomain structures reveal a canonical adhesive interface - Nature

Nectin ectodomain structures reveal a canonical adhesive interface  Nature

Atomic structure of the Y complex of the nuclear pore - Nature

Atomic structure of the Y complex of the nuclear pore  Nature

Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery - Na...

Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery  Nature

Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction -...

Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction  Nature

DICER- and AGO3-dependent generation of retinoic acid–induced DR2 Alu RNAs regulates human stem c...

DICER- and AGO3-dependent generation of retinoic acid–induced DR2 Alu RNAs regulates human stem cell proliferation  Nature

Structural basis of respiratory syncytial virus neutralization by motavizumab - Nature

Structural basis of respiratory syncytial virus neutralization by motavizumab  Nature

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition - Na...

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition  Nature

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab - Nature

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab  Nature

Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway...

Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway  Nature

Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistanc...

Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance  Nature

The microtubule-associated tau protein has intrinsic acetyltransferase activity - Nature

The microtubule-associated tau protein has intrinsic acetyltransferase activity  Nature

Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherin...

Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherins  Nature

Friedreich's ataxia–associated GAA repeats induce replication-fork reversal and unusual molecular...

Friedreich's ataxia–associated GAA repeats induce replication-fork reversal and unusual molecular junctions  Nature

Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures - ...

Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures  Nature

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells - Nature

SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells  Nature

An accurately preorganized IRES RNA structure enables eIF4G capture for initiation of viral trans...

An accurately preorganized IRES RNA structure enables eIF4G capture for initiation of viral translation  Nature

Supramolecular SNARE assembly precedes hemifusion in SNARE-mediated membrane fusion - Nature

Supramolecular SNARE assembly precedes hemifusion in SNARE-mediated membrane fusion  Nature

Cis -acting noncoding RNAs: friends and foes - Nature

Cis -acting noncoding RNAs: friends and foes  Nature

Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins - ...

Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins  Nature

The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks - Nature

The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks  Nature