60 New Super Mario Bros. for Nintendo DS tracks added to Nintendo Music - Nintendo Wire

60 New Super Mario Bros. for Nintendo DS tracks added to Nintendo Music  Nintendo Wire

NSMB’s 30th anniversary: shining a light on the invisible - Nature

NSMB’s 30th anniversary: shining a light on the invisible  Nature

Early embryonic-like cells are induced by downregulating replication-dependent chromatin assembly...

Early embryonic-like cells are induced by downregulating replication-dependent chromatin assembly  Nature

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein - Nature

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein  Nature

Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit...

Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit  Nature

A family of macrodomain proteins reverses cellular mono-ADP-ribosylation - Nature

A family of macrodomain proteins reverses cellular mono-ADP-ribosylation  Nature

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks ...

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks  Nature

Molecular basis for N-terminal acetylation by the heterodimeric NatA complex - Nature

Molecular basis for N-terminal acetylation by the heterodimeric NatA complex  Nature

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis - Nature

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis  Nature

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutatio...

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations  Nature

An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem ...

An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells  Nature

Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states - Nature

Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states  Nature

A) recruits and repels proteins to regulate mRNA homeostasis - Nature

A) recruits and repels proteins to regulate mRNA homeostasis  Nature

Fluorescent fusion protein knockout mediated by anti-GFP nanobody - Nature

Fluorescent fusion protein knockout mediated by anti-GFP nanobody  Nature

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ - Nature

The helicase domain of Polθ counteracts RPA to promote alt-NHEJ  Nature

Mechanistic diversity in ATP-binding cassette (ABC) transporters - Nature

Mechanistic diversity in ATP-binding cassette (ABC) transporters  Nature

Stage-specific assembly events of the 6-MDa small-subunit processome initiate eukaryotic ribosome...

Stage-specific assembly events of the 6-MDa small-subunit processome initiate eukaryotic ribosome biogenesis  Nature

Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase ac...

Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity  Nature

A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex -...

A molecular code for endosomal recycling of phosphorylated cargos by the SNX27–retromer complex  Nature

Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation - Na...

Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation  Nature

Structure and assembly of the NOT module of the human CCR4–NOT complex - Nature

Structure and assembly of the NOT module of the human CCR4–NOT complex  Nature

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site - Nature

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site  Nature

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome - Nature

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome  Nature

A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal fu...

A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function  Nature

Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells - Nature

Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells  Nature

Xist -dependent imprinted X inactivation and the early developmental consequences of its failure ...

Xist -dependent imprinted X inactivation and the early developmental consequences of its failure  Nature

Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation ...

Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation  Nature

Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality contr...

Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality control  Nature

Membrane insertion of a Tc toxin in near-atomic detail - Nature

Membrane insertion of a Tc toxin in near-atomic detail  Nature

Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1 - Nature

Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1  Nature

The energy landscape of adenylate kinase during catalysis - Nature

The energy landscape of adenylate kinase during catalysis  Nature

Naive pluripotency is associated with global DNA hypomethylation - Nature

Naive pluripotency is associated with global DNA hypomethylation  Nature

Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre -...

Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre  Nature

Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase - Nature

Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase  Nature

Molecular basis of lipid-linked oligosaccharide recognition and processing by bacterial oligosacc...

Molecular basis of lipid-linked oligosaccharide recognition and processing by bacterial oligosaccharyltransferase  Nature

Crystal structure of a monomeric retroviral protease solved by protein folding game players - Nature

Crystal structure of a monomeric retroviral protease solved by protein folding game players  Nature

Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43 - Nature

Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43  Nature

A U1 snRNP–specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange ...

A U1 snRNP–specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange  Nature

New insights into ubiquitin E3 ligase mechanism - Nature

New insights into ubiquitin E3 ligase mechanism  Nature

Post-translational modifications in signal integration - Nature

Post-translational modifications in signal integration  Nature

The evolutionary journey of Argonaute proteins - Nature

The evolutionary journey of Argonaute proteins  Nature

Structural basis of the specificity of USP18 toward ISG15 - Nature

Structural basis of the specificity of USP18 toward ISG15  Nature

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A ...

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses  Nature

Structure of the retinoid X receptor α–liver X receptor β (RXRα–LXRβ) heterodimer on DNA - Nature

Structure of the retinoid X receptor α–liver X receptor β (RXRα–LXRβ) heterodimer on DNA  Nature

Cleaning up in the endoplasmic reticulum: ubiquitin in charge - Nature

Cleaning up in the endoplasmic reticulum: ubiquitin in charge  Nature

NuRD–ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination - ...

NuRD–ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination  Nature

Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins - Nature

Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins  Nature

An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin...

An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains  Nature

53BP1 fosters fidelity of homology-directed DNA repair - Nature

53BP1 fosters fidelity of homology-directed DNA repair  Nature

Crystal structure of human stearoyl–coenzyme A desaturase in complex with substrate - Nature

Crystal structure of human stearoyl–coenzyme A desaturase in complex with substrate  Nature

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's ...

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease  Nature

The RNA-binding protein repertoire of embryonic stem cells - Nature

The RNA-binding protein repertoire of embryonic stem cells  Nature

Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specific...

Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity  Nature

Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine desi...

Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design  Nature

A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly - Nature

A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly  Nature

Structural basis for activity of highly efficient RNA mimics of green fluorescent protein - Nature

Structural basis for activity of highly efficient RNA mimics of green fluorescent protein  Nature

Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression - Nature

Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression  Nature

Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational foldin...

Evolutionary conservation of codon optimality reveals hidden signatures of cotranslational folding  Nature

Structural basis for regulation of Arp2/3 complex by GMF - Nature

Structural basis for regulation of Arp2/3 complex by GMF  Nature

Structural basis of the proinflammatory signaling complex mediated by TSLP - Nature

Structural basis of the proinflammatory signaling complex mediated by TSLP  Nature

Structure of the active form of Dcp1–Dcp2 decapping enzyme bound to m - Nature

Structure of the active form of Dcp1–Dcp2 decapping enzyme bound to m  Nature

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2 - Nature

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2  Nature

Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres - Na...

Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres  Nature

Structural basis for bifunctional peptide recognition at human δ-opioid receptor - Nature

Structural basis for bifunctional peptide recognition at human δ-opioid receptor  Nature

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab - Nature

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab  Nature

Toll-like receptor 8 senses degradation products of single-stranded RNA - Nature

Toll-like receptor 8 senses degradation products of single-stranded RNA  Nature

Sequence composition of disordered regions fine-tunes protein half-life - Nature

Sequence composition of disordered regions fine-tunes protein half-life  Nature

Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing path...

Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway  Nature

Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase - Nature

Molecular basis for pseudokinase-dependent autoinhibition of JAK2 tyrosine kinase  Nature

Structural basis of enzyme encapsulation into a bacterial nanocompartment - Nature

Structural basis of enzyme encapsulation into a bacterial nanocompartment  Nature

Human CTP synthase filament structure reveals the active enzyme conformation - Nature

Human CTP synthase filament structure reveals the active enzyme conformation  Nature

An assessment of histone-modification antibody quality - Nature

An assessment of histone-modification antibody quality  Nature

Determinants of nucleosome positioning - Nature

Determinants of nucleosome positioning  Nature

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid clie...

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client  Nature

iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution - N...

iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution  Nature

Perceiving the epigenetic landscape through histone readers - Nature

Perceiving the epigenetic landscape through histone readers  Nature

A global profile of replicative polymerase usage - Nature

A global profile of replicative polymerase usage  Nature

Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges - ...

Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges  Nature

Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin o...

Solid-state NMR and SAXS studies provide a structural basis for the activation of αB-crystallin oligomers  Nature

Extended surface for membrane association in Zika virus NS1 structure - Nature

Extended surface for membrane association in Zika virus NS1 structure  Nature

Superwobbling facilitates translation with reduced tRNA sets - Nature

Superwobbling facilitates translation with reduced tRNA sets  Nature

The program for processing newly synthesized histones H3.1 and H4 - Nature

The program for processing newly synthesized histones H3.1 and H4  Nature

Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28...

Structural basis of pre-let-7 miRNA recognition by the zinc knuckles of pluripotency factor Lin28  Nature

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact ...

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4–NOT  Nature

Large-scale mapping of branchpoints in human pre-mRNA transcripts in vivo - Nature

Large-scale mapping of branchpoints in human pre-mRNA transcripts in vivo  Nature

Cryo-electron microscopy structure of the TRPV2 ion channel - Nature

Cryo-electron microscopy structure of the TRPV2 ion channel  Nature

The role of lipids in mechanosensation - Nature

The role of lipids in mechanosensation  Nature

The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity - Na...

The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity  Nature

Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain - Nature

Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain  Nature

Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site select...

Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity  Nature

A transcription factor–based mechanism for mouse heterochromatin formation - Nature

A transcription factor–based mechanism for mouse heterochromatin formation  Nature

Structure and VP16 binding of the Mediator Med25 activator interaction domain - Nature

Structure and VP16 binding of the Mediator Med25 activator interaction domain  Nature

Structural determinants of integrin β-subunit specificity for latent TGF-β - Nature

Structural determinants of integrin β-subunit specificity for latent TGF-β  Nature

A 3D cellular context for the macromolecular world - Nature

A 3D cellular context for the macromolecular world  Nature

A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding ...

A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding  Nature

Structural basis of HIV-1 resistance to AZT by excision - Nature

Structural basis of HIV-1 resistance to AZT by excision  Nature

Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases - Nature

Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases  Nature

Structure of human mitochondrial RNA polymerase elongation complex - Nature

Structure of human mitochondrial RNA polymerase elongation complex  Nature

Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase REC...

Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5  Nature

Structural insights into the mechanism of abscisic acid signaling by PYL proteins - Nature

Structural insights into the mechanism of abscisic acid signaling by PYL proteins  Nature