New Super Mario Bros. U Deluxe: All of the secret exits and world skips - Digital Trends

New Super Mario Bros. U Deluxe: All of the secret exits and world skips  Digital Trends

Is a New Super Mario Bros Collection Coming to Switch 2? - VICE

Is a New Super Mario Bros Collection Coming to Switch 2?  VICE

NSMB’s 30th anniversary: shining a light on the invisible - Nature

NSMB’s 30th anniversary: shining a light on the invisible  Nature

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein - Nature

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein  Nature

Fluorescent fusion protein knockout mediated by anti-GFP nanobody - Nature

Fluorescent fusion protein knockout mediated by anti-GFP nanobody  Nature

Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit...

Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit  Nature

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome - Nature

PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome  Nature

Stage-specific assembly events of the 6-MDa small-subunit processome initiate eukaryotic ribosome...

Stage-specific assembly events of the 6-MDa small-subunit processome initiate eukaryotic ribosome biogenesis  Nature

Detecting endogenous SUMO targets in mammalian cells and tissues - Nature

Detecting endogenous SUMO targets in mammalian cells and tissues  Nature

A global profile of replicative polymerase usage - Nature

A global profile of replicative polymerase usage  Nature

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis - Nature

RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis  Nature

Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality contr...

Preribosomes escaping from the nucleus are caught during translation by cytoplasmic quality control  Nature

Molecular basis for N-terminal acetylation by the heterodimeric NatA complex - Nature

Molecular basis for N-terminal acetylation by the heterodimeric NatA complex  Nature

A family of macrodomain proteins reverses cellular mono-ADP-ribosylation - Nature

A family of macrodomain proteins reverses cellular mono-ADP-ribosylation  Nature

Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43 - Nature

Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43  Nature

An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem ...

An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells  Nature

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutatio...

The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations  Nature

Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases - Nature

Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases  Nature

Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states - Nature

Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states  Nature

Structure and assembly of the NOT module of the human CCR4–NOT complex - Nature

Structure and assembly of the NOT module of the human CCR4–NOT complex  Nature

Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase - Nature

Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase  Nature

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid clie...

The chaperone αB-crystallin uses different interfaces to capture an amorphous and an amyloid client  Nature

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis...

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis  Nature

regulation of the TRP channel Polycystin-2 - Nature

regulation of the TRP channel Polycystin-2  Nature

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site - Nature

The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site  Nature

Sequence composition of disordered regions fine-tunes protein half-life - Nature

Sequence composition of disordered regions fine-tunes protein half-life  Nature

Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specific...

Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity  Nature

Structural and mechanistic insight into Holliday-junction dissolution by Topoisomerase IIIα and R...

Structural and mechanistic insight into Holliday-junction dissolution by Topoisomerase IIIα and RMI1  Nature

Why New Super Mario Bros. 2 Cannot Rest on the Original's Laurels - Nintendo World Report

Why New Super Mario Bros. 2 Cannot Rest on the Original's Laurels  Nintendo World Report

Large-scale mapping of branchpoints in human pre-mRNA transcripts in vivo - Nature

Large-scale mapping of branchpoints in human pre-mRNA transcripts in vivo  Nature

Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells - Nature

Single-cell RNA-Seq profiling of human preimplantation embryos and embryonic stem cells  Nature

Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV - Nature

Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV  Nature

Superwobbling facilitates translation with reduced tRNA sets - Nature

Superwobbling facilitates translation with reduced tRNA sets  Nature

Crystal structure of human stearoyl–coenzyme A desaturase in complex with substrate - Nature

Crystal structure of human stearoyl–coenzyme A desaturase in complex with substrate  Nature

Structure of the retinoid X receptor α–liver X receptor β (RXRα–LXRβ) heterodimer on DNA - Nature

Structure of the retinoid X receptor α–liver X receptor β (RXRα–LXRβ) heterodimer on DNA  Nature

Crystal structure of a monomeric retroviral protease solved by protein folding game players - Nature

Crystal structure of a monomeric retroviral protease solved by protein folding game players  Nature

Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1 - Nature

Structural basis for MOF and MSL3 recruitment into the dosage compensation complex by MSL1  Nature

A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cel...

A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells  Nature

The role of lipids in mechanosensation - Nature

The role of lipids in mechanosensation  Nature

Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation - Na...

Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation  Nature

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mecha...

Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism  Nature

NMR Exchange Format: a unified and open standard for representation of NMR restraint data - Nature

NMR Exchange Format: a unified and open standard for representation of NMR restraint data  Nature

An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin...

An ankyrin-repeat ubiquitin-binding domain determines TRABID's specificity for atypical ubiquitin chains  Nature

The RNA-binding protein repertoire of embryonic stem cells - Nature

The RNA-binding protein repertoire of embryonic stem cells  Nature

Phosphorylation-dependent activity of the deubiquitinase DUBA - Nature

Phosphorylation-dependent activity of the deubiquitinase DUBA  Nature

Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins - Nature

Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins  Nature

A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization...

A cancer-associated BRCA2 mutation reveals masked nuclear export signals controlling localization  Nature

miRNA repression involves GW182-mediated recruitment of CCR4–NOT through conserved W-containing m...

miRNA repression involves GW182-mediated recruitment of CCR4–NOT through conserved W-containing motifs  Nature

A novel actin binding site of myosin required for effective muscle contraction - Nature

A novel actin binding site of myosin required for effective muscle contraction  Nature

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's ...

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease  Nature

Assembly, analysis and architecture of atypical ubiquitin chains - Nature

Assembly, analysis and architecture of atypical ubiquitin chains  Nature

-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics - Nature

-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamics  Nature

A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal fu...

A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function  Nature

Toll-like receptor 8 senses degradation products of single-stranded RNA - Nature

Toll-like receptor 8 senses degradation products of single-stranded RNA  Nature

The evolutionary journey of Argonaute proteins - Nature

The evolutionary journey of Argonaute proteins  Nature

MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD - Nature

MacroH2A1.1 regulates mitochondrial respiration by limiting nuclear NAD  Nature

An assessment of histone-modification antibody quality - Nature

An assessment of histone-modification antibody quality  Nature

Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation - Nature

Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation  Nature

ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay - Nature

ADAR1 controls apoptosis of stressed cells by inhibiting Staufen1-mediated mRNA decay  Nature

Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induce...

Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization  Nature

Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing path...

Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway  Nature

Intrinsic histone-DNA interactions are not the major determinant of nucleosome positions in vivo ...

Intrinsic histone-DNA interactions are not the major determinant of nucleosome positions in vivo  Nature

receptor bound to clinical antagonist bosentan and its analog - Nature

receptor bound to clinical antagonist bosentan and its analog  Nature

The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1A - Na...

The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1A  Nature

An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse...

An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3  Nature

Cooperative three-step motions in catalytic subunits of F - Nature

Cooperative three-step motions in catalytic subunits of F  Nature

Studies of IscR reveal a unique mechanism for metal-dependent regulation of DNA binding specifici...

Studies of IscR reveal a unique mechanism for metal-dependent regulation of DNA binding specificity  Nature

Chromatin signatures and retrotransposon profiling in mouse embryos reveal regulation of LINE-1 b...

Chromatin signatures and retrotransposon profiling in mouse embryos reveal regulation of LINE-1 by RNA  Nature

Polymerase δ replicates both strands after homologous recombination–dependent fork restart - Nature

Polymerase δ replicates both strands after homologous recombination–dependent fork restart  Nature

Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation - Nature

Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation  Nature

Copper-transporting P-type ATPases use a unique ion-release pathway - Nature

Copper-transporting P-type ATPases use a unique ion-release pathway  Nature

An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and dec...

An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay  Nature

Structure-function analyses of the human SIX1–EYA2 complex reveal insights into metastasis and BO...

Structure-function analyses of the human SIX1–EYA2 complex reveal insights into metastasis and BOR syndrome  Nature

The structural basis of autotransporter translocation by TamA - Nature

The structural basis of autotransporter translocation by TamA  Nature

Structural basis of enzyme encapsulation into a bacterial nanocompartment - Nature

Structural basis of enzyme encapsulation into a bacterial nanocompartment  Nature

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2 - Nature

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2  Nature

Biological basis for restriction of microRNA targets to the 3′ untranslated region in mammalian m...

Biological basis for restriction of microRNA targets to the 3′ untranslated region in mammalian mRNAs  Nature

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism - Nature

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism  Nature

Determinants of nucleosome positioning - Nature

Determinants of nucleosome positioning  Nature

Structural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-t...

Structural dynamics of the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase  Nature

Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation - ...

Spiral architecture of the Hsp104 disaggregase reveals the basis for polypeptide translocation  Nature

Perceiving the epigenetic landscape through histone readers - Nature

Perceiving the epigenetic landscape through histone readers  Nature

Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex - Nature

Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex  Nature

iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution - N...

iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution  Nature

Conformational ensemble of the sodium-coupled aspartate transporter - Nature

Conformational ensemble of the sodium-coupled aspartate transporter  Nature

A 3D cellular context for the macromolecular world - Nature

A 3D cellular context for the macromolecular world  Nature

Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses - Nature

Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses  Nature

Cryo-electron microscopy structure of the TRPV2 ion channel - Nature

Cryo-electron microscopy structure of the TRPV2 ion channel  Nature

Converging concepts of protein folding in vitro and in vivo - Nature

Converging concepts of protein folding in vitro and in vivo  Nature

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A ...

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses  Nature

Extended surface for membrane association in Zika virus NS1 structure - Nature

Extended surface for membrane association in Zika virus NS1 structure  Nature

Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 pro...

Structural basis for dimethylarginine recognition by the Tudor domains of human SMN and SPF30 proteins  Nature

Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine desi...

Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design  Nature

Structural basis for activity of highly efficient RNA mimics of green fluorescent protein - Nature

Structural basis for activity of highly efficient RNA mimics of green fluorescent protein  Nature

Mechanics of membrane fusion - Nature

Mechanics of membrane fusion  Nature

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation - N...

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation  Nature

A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding ...

A structural ensemble of a ribosome–nascent chain complex during cotranslational protein folding  Nature

Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40 ...

Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40  Nature

Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase REC...

Structural mimicry in transcription regulation of human RNA polymerase II by the DNA helicase RECQL5  Nature

Structures of the human mitochondrial ribosome in native states of assembly - Nature

Structures of the human mitochondrial ribosome in native states of assembly  Nature