First Clinical Investigation of a Gene Therapy (YAP101) to Induce Cardiac Regeneration to Treat H...

First Clinical Investigation of a Gene Therapy (YAP101) to Induce Cardiac Regeneration to Treat Heart Failure Passes Initial Safety Hurdle  Business Wire

Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression - Na...

Phase separation of YAP reorganizes genome topology for long-term YAP target gene expression  Nature

Targeting a gene that controls tissue growth, scientists reveal regenerative path for treating di...

Targeting a gene that controls tissue growth, scientists reveal regenerative path for treating diabetic foot ulcers  Scripps Research

MISP Suppresses Ferroptosis via MST1/2 Kinases to Facilitate YAP Activation in Non-Small Cell Lun...

MISP Suppresses Ferroptosis via MST1/2 Kinases to Facilitate YAP Activation in Non-Small Cell Lung Cancer  Wiley

YAP protein identified as new target for Alzheimer’s disease - Drug Target Review

YAP protein identified as new target for Alzheimer’s disease  Drug Target Review

A degradable form of polyoma small T antigen reveals the high specificity of TAZ in regulating ge...

A degradable form of polyoma small T antigen reveals the high specificity of TAZ in regulating gene expression  PNAS

New study shows cancer-causing ‘Frankengene’ mutation could be target for new drugs - Fred Hutchi...

New study shows cancer-causing ‘Frankengene’ mutation could be target for new drugs  Fred Hutchinson Cancer Center

Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration | Circulation Re...

Yap Promotes Noncanonical Wnt Signals From Cardiomyocytes for Heart Regeneration | Circulation Research  American Heart Association Journals

YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for ...

YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity  Nature

Hippo pathway effector Yap promotes cardiac regeneration - PNAS

Hippo pathway effector Yap promotes cardiac regeneration  PNAS

The circadian gene ARNTL2 promotes nasopharyngeal carcinoma invasiveness and metastasis through s...

The circadian gene ARNTL2 promotes nasopharyngeal carcinoma invasiveness and metastasis through suppressing AMOTL2-LATS-YAP pathway  Nature

Cancer lineage-specific regulation of YAP responsive elements revealed through large-scale functi...

Cancer lineage-specific regulation of YAP responsive elements revealed through large-scale functional epigenomic screens  Nature

Optogenetic control of YAP reveals a dynamic communication code for stem cell fate and proliferat...

Optogenetic control of YAP reveals a dynamic communication code for stem cell fate and proliferation  Nature

YAP Activity is Not Associated with Survival of Uveal Melanoma Patients and Cell Lines - Nature

YAP Activity is Not Associated with Survival of Uveal Melanoma Patients and Cell Lines  Nature

UBR1 promotes anaplastic thyroid carcinoma progression via stabilizing YAP through monoubiquityla...

UBR1 promotes anaplastic thyroid carcinoma progression via stabilizing YAP through monoubiquitylation  Nature

FRMD6 determines the cell fate towards senescence: involvement of the Hippo-YAP-CCN3 axis - Nature

FRMD6 determines the cell fate towards senescence: involvement of the Hippo-YAP-CCN3 axis  Nature

Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac matura...

Cardiomyocyte proliferation is suppressed by ARID1A-mediated YAP inhibition during cardiac maturation  Nature

Fat3 regulates neural progenitor cells by promoting Yap activity during spinal cord development -...

Fat3 regulates neural progenitor cells by promoting Yap activity during spinal cord development  Nature

ARSD, a novel ERα downstream target gene, inhibits proliferation and migration of breast cancer c...

ARSD, a novel ERα downstream target gene, inhibits proliferation and migration of breast cancer cells via activating Hippo/YAP pathway  Nature

EWS-FLI1 perturbs MRTFB/YAP-1/TEAD target gene regulation inhibiting cytoskeletal autoregulatory ...

EWS-FLI1 perturbs MRTFB/YAP-1/TEAD target gene regulation inhibiting cytoskeletal autoregulatory feedback in Ewing sarcoma  Nature

breast cancer growth by disrupting a TEAD-ERα signaling axis - Nature

breast cancer growth by disrupting a TEAD-ERα signaling axis  Nature

Gene expression profiles of YAP1, TAZ, CRB3, and VDR in familial and sporadic multiple sclerosis ...

Gene expression profiles of YAP1, TAZ, CRB3, and VDR in familial and sporadic multiple sclerosis among an Iranian population  Nature

YAP1 gene fusions are oncogenic drivers in several tumor types and potential therapeutic targets ...

YAP1 gene fusions are oncogenic drivers in several tumor types and potential therapeutic targets  Fred Hutchinson Cancer Center

YAP 5-methylcytosine modification increases its mRNA stability and promotes the transcription of ...

YAP 5-methylcytosine modification increases its mRNA stability and promotes the transcription of exosome secretion-related genes in lung adenocarcinoma  Nature

Musculoskeletal defects associated with myosin heavy chain‐embryonic loss of function are mediate...

Musculoskeletal defects associated with myosin heavy chain‐embryonic loss of function are mediated by the YAP signaling pathway  Springer

Regulation of Hippo/YAP axis in colon cancer progression by the deubiquitinase JOSD1 - Nature

Regulation of Hippo/YAP axis in colon cancer progression by the deubiquitinase JOSD1  Nature

Transformation of normal cells by aberrant activation of YAP via cMyc with TEAD - Nature

Transformation of normal cells by aberrant activation of YAP via cMyc with TEAD  Nature

Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associate...

Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts  Nature

Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therape...

Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER  Nature

Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) c...

Extracellular signal-Regulated Kinase 5 (ERK5) is required for the Yes-associated protein (YAP) co-transcriptional activity | Cell Death & Disease  Nature

Hippo pathway in non-small cell lung cancer: mechanisms, potential targets, and biomarkers - Nature

Hippo pathway in non-small cell lung cancer: mechanisms, potential targets, and biomarkers  Nature

The spectraplakin Dystonin antagonizes YAP activity and suppresses tumourigenesis - Nature

The spectraplakin Dystonin antagonizes YAP activity and suppresses tumourigenesis  Nature

The RNA helicase DDX21 activates YAP to promote tumorigenesis and is transcriptionally upregulate...

The RNA helicase DDX21 activates YAP to promote tumorigenesis and is transcriptionally upregulated by β-catenin in colorectal cancer  Nature

Expression of foetal gene Pontin is essential in protecting heart against pathological remodellin...

Expression of foetal gene Pontin is essential in protecting heart against pathological remodelling and cardiomyopathy  Nature

Ionizing radiation-induced long noncoding RNA CRYBG3 regulates YAP/TAZ through mechanotransductio...

Ionizing radiation-induced long noncoding RNA CRYBG3 regulates YAP/TAZ through mechanotransduction  Nature

Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers ...

Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ  Nature

A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis - Nature

A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis  Nature

LncRNA SFTA1P mediates positive feedback regulation of the Hippo-YAP/TAZ signaling pathway in non...

LncRNA SFTA1P mediates positive feedback regulation of the Hippo-YAP/TAZ signaling pathway in non-small cell lung cancer  Nature

Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial ...

Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction  Science | AAAS

Yap haploinsufficiency leads to Müller cell dysfunction and late-onset cone dystrophy - Nature

Yap haploinsufficiency leads to Müller cell dysfunction and late-onset cone dystrophy  Nature

A basal-like breast cancer-specific role for SRF–IL6 in YAP-induced cancer stemness - Nature

A basal-like breast cancer-specific role for SRF–IL6 in YAP-induced cancer stemness  Nature

MST1/Hippo promoter gene methylation predicts poor survival in patients with malignant pleural me...

MST1/Hippo promoter gene methylation predicts poor survival in patients with malignant pleural mesothelioma in the IFCT-GFPC-0701 MAPS Phase 3 trial | British Journal of Cancer  Nature

YAP dysregulation by phosphorylation or ΔNp63-mediated gene repression promotes proliferation, su...

YAP dysregulation by phosphorylation or ΔNp63-mediated gene repression promotes proliferation, survival and migration in head and neck cancer subsets  Nature

Yes-associated protein (YAP) functions as a tumor suppressor in breast - Nature

Yes-associated protein (YAP) functions as a tumor suppressor in breast  Nature

Nectin-4 and p95-ErbB2 cooperatively regulate Hippo signaling-dependent SOX2 gene expression, enh...

Nectin-4 and p95-ErbB2 cooperatively regulate Hippo signaling-dependent SOX2 gene expression, enhancing anchorage-independent T47D cell proliferation  Nature

YAP1 oncogene and its eight isoforms - Nature

YAP1 oncogene and its eight isoforms  Nature

Gravity-resisting gene stops our bodies being squashed flat - University of Bath

Gravity-resisting gene stops our bodies being squashed flat  University of Bath