Harnessing IL-2 for immunotherapy against cancer and chronic infection: a historical perspective ...

Harnessing IL-2 for immunotherapy against cancer and chronic infection: a historical perspective and emerging trends  Nature.com

2024 Drug Approvals in Review: Part 2 - Dermatology Times

2024 Drug Approvals in Review: Part 2  Dermatology Times

Scientists Identify Key Biomarkers That May Predict Low-Dose IL-2 Treatment Efficacy in People wi...

Scientists Identify Key Biomarkers That May Predict Low-Dose IL-2 Treatment Efficacy in People with Systemic Lupus Erythematosus  Lupus Foundation of America

An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to...

An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to promote T cell anergy  sciencedirect.com

IL-2-free tumor-infiltrating lymphocyte therapy with PD-1 blockade demonstrates potent efficacy i...

IL-2-free tumor-infiltrating lymphocyte therapy with PD-1 blockade demonstrates potent efficacy in advanced gynecologic cancer  BMC Medicine

BCANTT 2024: Rationally Engineered IL2 for Enhanced Treatment of Local and Metastatic Bladder Can...

BCANTT 2024: Rationally Engineered IL2 for Enhanced Treatment of Local and Metastatic Bladder Cancer  UroToday

IL-2 based cancer immunotherapies: an evolving paradigm - Frontiers

IL-2 based cancer immunotherapies: an evolving paradigm  Frontiers

Coya touts partnership potential as IL-2 prospect comes through small Alzheimer's study - Fierce ...

Coya touts partnership potential as IL-2 prospect comes through small Alzheimer's study  Fierce Biotech

Cleanup on IL-2 - Science

Cleanup on IL-2  Science

IL-2 Receptor-Targeted Therapy Approved for Relapsed/Refractory CTCL - Medpage Today

IL-2 Receptor-Targeted Therapy Approved for Relapsed/Refractory CTCL  Medpage Today

IL-2/anti-IL-2 antibody complexes augment immune responses to therapeutic cancer vaccines - pnas.org

IL-2/anti-IL-2 antibody complexes augment immune responses to therapeutic cancer vaccines  pnas.org

Low-dose IL-2 promising in bullous pemphigoid treatment - Healio

Low-dose IL-2 promising in bullous pemphigoid treatment  Healio

Aulos Bioscience Presents Phase 2 Dose Selection Data for Novel IL-2 Therapeutic Antibody, AU-007...

Aulos Bioscience Presents Phase 2 Dose Selection Data for Novel IL-2 Therapeutic Antibody, AU-007, at 36th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics  Business Wire

Targeting systemic IL-2 to BCMA CAR-T cells - Nature.com

Targeting systemic IL-2 to BCMA CAR-T cells  Nature.com

Human serum albumin promotes interactions between HSA-IL-2 fusion protein and CD122 for enhancing...

Human serum albumin promotes interactions between HSA-IL-2 fusion protein and CD122 for enhancing immunotherapy  sciencedirect.com

T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics - ...

T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics  Nature.com

PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function - Nature.com

PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function  Nature.com

Spatial microniches of IL-2 combine with IL-10 to drive lung migratory T - Nature.com

Spatial microniches of IL-2 combine with IL-10 to drive lung migratory T  Nature.com

The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer - Nature.com

The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer  Nature.com

The regulatory T cell-selective interleukin-2 receptor agonist rezpegaldesleukin in the treatment...

The regulatory T cell-selective interleukin-2 receptor agonist rezpegaldesleukin in the treatment of inflammatory skin diseases: two randomized, double-blind, placebo-controlled phase 1b trials  Nature.com

Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T ...

Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation  Nature.com

Aulos Bioscience to Present Promising Phase 2 Data for Novel IL-2 Therapeutic Antibody, AU-007, a...

Aulos Bioscience to Present Promising Phase 2 Data for Novel IL-2 Therapeutic Antibody, AU-007, at 39th Society for Immunotherapy of Cancer (SITC) Annual Meeting  Business Wire

Overcoming toxicities: are IL-2 smart cytokines the next big thing? - Labiotech.eu

Overcoming toxicities: are IL-2 smart cytokines the next big thing?  Labiotech.eu

A CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organism - Nat...

A CD25-biased interleukin-2 for autoimmune therapy engineered via a semi-synthetic organism  Nature.com

Low Dose Interleukin-2 Ameliorates Sjögren’s Syndrome in a Murine Model - Frontiers

Low Dose Interleukin-2 Ameliorates Sjögren’s Syndrome in a Murine Model  Frontiers

Early Serum IL-2 Levels Are Associated With CAR T-Cell Expansion Post–CAR T-Cell Therapy - OncLive

Early Serum IL-2 Levels Are Associated With CAR T-Cell Expansion Post–CAR T-Cell Therapy  OncLive

A single-agent fusion of human IL-2 and anti-IL-2 antibody that selectively expands regulatory T ...

A single-agent fusion of human IL-2 and anti-IL-2 antibody that selectively expands regulatory T cells  Nature.com

Interleukin‐2‐mediated CD4 T‐cell activation correlates highly with effective serological and T‐c...

Interleukin‐2‐mediated CD4 T‐cell activation correlates highly with effective serological and T‐cell responses to SARS‐CoV‐2 vaccination in people living with HIV - Gupta - 2024 - Journal of Medical Virology  Wiley Online Library

Innovent braves bruising cytokine space, linking fusion protein to tumor responses in small study...

Innovent braves bruising cytokine space, linking fusion protein to tumor responses in small study  Fierce Biotech

Harnessing IGF-1 and IL-2 as biomarkers for calcineurin activity to tailor optimal FK506 dosage i...

Harnessing IGF-1 and IL-2 as biomarkers for calcineurin activity to tailor optimal FK506 dosage in α-synucleinopathies  Frontiers

Interleukin-2 is required for NKp30-dependent NK cell cytotoxicity by preferentially regulating N...

Interleukin-2 is required for NKp30-dependent NK cell cytotoxicity by preferentially regulating NKp30 expression  Frontiers

flux and suppresses interleukin-2 production by enhancing the expression of GM2 on the surface me...

flux and suppresses interleukin-2 production by enhancing the expression of GM2 on the surface membrane  Nature.com

Abstract 4144964: Low-Dose IL-2 Lowers Arterial Inflammation and Trends Towards Lower MACE in pat...

Abstract 4144964: Low-Dose IL-2 Lowers Arterial Inflammation and Trends Towards Lower MACE in patients with ACS: The results of the IVORY trial and IVORY FINALE study  AHA Journals

Report of the Validation of the IL-2 Luc Leukocyte Toxicity Test (IL-2 Luc LTT) Assay on In Vitro...

Report of the Validation of the IL-2 Luc Leukocyte Toxicity Test (IL-2 Luc LTT) Assay on In Vitro Immuno-Toxicity Testing  OECD

IL-2 and TCR stimulation induce expression and secretion of IL-32β by human T cells - Frontiers

IL-2 and TCR stimulation induce expression and secretion of IL-32β by human T cells  Frontiers

Development at Rockford’s US-20 and IL-2 interchange could soon bring 37,000 jobs - MyStateline.com

Development at Rockford’s US-20 and IL-2 interchange could soon bring 37,000 jobs  MyStateline.com

Combined analysis of host IFN-γ, IL-2 and IP-10 as potential LTBI biomarkers in ESAT-6/CFP-10 sti...

Combined analysis of host IFN-γ, IL-2 and IP-10 as potential LTBI biomarkers in ESAT-6/CFP-10 stimulated blood  Frontiers

Novel IL-2 Agent Shows Promise in Advanced Solid Tumors - Medpage Today

Novel IL-2 Agent Shows Promise in Advanced Solid Tumors  Medpage Today

Synthekine Announces Presentation of New Translational Data from Phase 1a/1b Clinical Trial of α/...

Synthekine Announces Presentation of New Translational Data from Phase 1a/1b Clinical Trial of α/β Biased IL-2, STK-012, at the Society for Immunotherapy of Cancer (SITC) 39th Annual Meeting  Business Wire

AACR: Synthekine hopes new IL-2 will be the high-alpha in a beta class - Fierce Biotech

AACR: Synthekine hopes new IL-2 will be the high-alpha in a beta class  Fierce Biotech

Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney tra...

Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney transplant recipients  Nature.com

A Comprehensive Review of Low-Dose Interleukin-2 (IL-2) Therapy for Systemic Lupus Erythematosus:...

A Comprehensive Review of Low-Dose Interleukin-2 (IL-2) Therapy for Systemic Lupus Erythematosus: Mechanisms, Efficacy, and Clinical Applications  Cureus

Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue...

Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue  Nature.com

The Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its D...

The Blockade of Interleukin-2 During the Acute Phase of Trypanosoma cruzi Infection Reveals Its Dominant Regulatory Role  Frontiers

Dr Olson on Toxicities Associated With Lifileucel and IL-2 in Melanoma - OncLive

Dr Olson on Toxicities Associated With Lifileucel and IL-2 in Melanoma  OncLive

Utilizing interleukin 2 for immune cell activation and expansion - News-Medical.Net

Utilizing interleukin 2 for immune cell activation and expansion  News-Medical.Net

IL‐2 amplifies quantitative TCR signalling inputs to drive Th1 and Th2 differentiation - Al‐Aghba...

IL‐2 amplifies quantitative TCR signalling inputs to drive Th1 and Th2 differentiation - Al‐Aghbar - 2024 - Immunology  Wiley Online Library

ESMO Virtual Plenary: Ph I trial of PD-1/IL-2 BsAb in pts with advanced cancer - European Society...

ESMO Virtual Plenary: Ph I trial of PD-1/IL-2 BsAb in pts with advanced cancer  European Society for Medical Oncology

Interleukin-2 Mediated Expansion of T-Regulatory Cells as an Ischemic Stroke Therapy - AHA Journals

Interleukin-2 Mediated Expansion of T-Regulatory Cells as an Ischemic Stroke Therapy  AHA Journals

IL-2 Korea Announcement - FSElite

IL-2 Korea Announcement  FSElite

Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B...

Optimized RNA interference therapeutics combined with interleukin-2 mRNA for treating hepatitis B virus infection  Nature.com

Interleukin (IL)-2 Is a Key Regulator of T Helper 1 and T Helper 2 Cytokine Expression in Fish: F...

Interleukin (IL)-2 Is a Key Regulator of T Helper 1 and T Helper 2 Cytokine Expression in Fish: Functional Characterization of Two Divergent IL2 Paralogs in Salmonids  Frontiers

Concomitant use of interleukin-2 and tacrolimus suppresses follicular helper T cell proportion an...

Concomitant use of interleukin-2 and tacrolimus suppresses follicular helper T cell proportion and exerts therapeutic effect against lupus nephritis in systemic lupus erythematosus-like chronic graft versus host disease  Frontiers

Defining the Threshold IL-2 Signal Required for Induction of Selective Treg Cell Responses Using ...

Defining the Threshold IL-2 Signal Required for Induction of Selective Treg Cell Responses Using Engineered IL-2 Muteins  Frontiers

Interleukin-2 Production by Dendritic Cells and its Immuno-Regulatory Functions - Frontiers

Interleukin-2 Production by Dendritic Cells and its Immuno-Regulatory Functions  Frontiers

Anti-cancer Therapies Employing IL-2 Cytokine Tumor Targeting: Contribution of Innate, Adaptive a...

Anti-cancer Therapies Employing IL-2 Cytokine Tumor Targeting: Contribution of Innate, Adaptive and Immunosuppressive Cells in the Anti-tumor Efficacy  Frontiers

The Potential of Harnessing IL-2-Mediated Immunosuppression to Prevent Pathogenic B Cell Response...

The Potential of Harnessing IL-2-Mediated Immunosuppression to Prevent Pathogenic B Cell Responses  Frontiers

Interleukin‐2‐induced skin inflammation - Sommer - 2024 - European Journal of Immunology - Wiley ...

Interleukin‐2‐induced skin inflammation - Sommer - 2024 - European Journal of Immunology  Wiley Online Library

The application of Interleukin-2 family cytokines in tumor immunotherapy research - Frontiers

The application of Interleukin-2 family cytokines in tumor immunotherapy research  Frontiers

The effects of low-dose IL-2 on Th17/Treg cell imbalance in primary biliary cholangitis mouse mod...

The effects of low-dose IL-2 on Th17/Treg cell imbalance in primary biliary cholangitis mouse models  BMC Gastroenterology

IFNγ-secreting T cells that highly express IL-2 potently inhibit the growth of intracellular M. t...

IFNγ-secreting T cells that highly express IL-2 potently inhibit the growth of intracellular M. tuberculosis in macrophages  Frontiers

Oncolytic Adenovirus Coding for a Variant Interleukin 2 (vIL-2) Cytokine Re-Programs the Tumor Mi...

Oncolytic Adenovirus Coding for a Variant Interleukin 2 (vIL-2) Cytokine Re-Programs the Tumor Microenvironment and Confers Enhanced Tumor Control  Frontiers

IL-2 Restores T-Cell Dysfunction Induced by Persistent Mycobacterium tuberculosis Antigen Stimula...

IL-2 Restores T-Cell Dysfunction Induced by Persistent Mycobacterium tuberculosis Antigen Stimulation  Frontiers

IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4+Foxp3+ regulatory ...

IL-2 and IL-15 drive intrathymic development of distinct periphery-seeding CD4+Foxp3+ regulatory T lymphocytes  Frontiers

JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL...

JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans  Nature.com

Efficient Secretion of Murine IL-2 From an Attenuated Strain of Clostridium sporogenes, a Novel D...

Efficient Secretion of Murine IL-2 From an Attenuated Strain of Clostridium sporogenes, a Novel Delivery Vehicle for Cancer Immunotherapy  Frontiers

A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models - JCI

A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models  JCI

PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells - Nature.com

PGE2 limits effector expansion of tumour-infiltrating stem-like CD8+ T cells  Nature.com

Ilyushin Il-2: 5 Fast Facts About The World’s Most Produced Warplane - Simple Flying

Ilyushin Il-2: 5 Fast Facts About The World’s Most Produced Warplane  Simple Flying

Supraphysiological Levels of IL-2 in Jak3-Deficient Mice Promote Strong Proliferative Responses o...

Supraphysiological Levels of IL-2 in Jak3-Deficient Mice Promote Strong Proliferative Responses of Adoptively Transferred Naive CD8+ T Cells  Frontiers

IL-2 Inhibition of Th17 Generation Rather Than Induction of Treg Cells Is Impaired in Primary Sjö...

IL-2 Inhibition of Th17 Generation Rather Than Induction of Treg Cells Is Impaired in Primary Sjögren’s Syndrome Patients  Frontiers

The combination of IL-2 nanoparticles and Palbociclib enhances the anti-tumor immune response for...

The combination of IL-2 nanoparticles and Palbociclib enhances the anti-tumor immune response for colon cancer therapy  Frontiers

The small molecule inhibitor BX-795 uncouples IL-2 production from inhibition of Th2 inflammation...

The small molecule inhibitor BX-795 uncouples IL-2 production from inhibition of Th2 inflammation and induces CD4  Frontiers

Case Report: Interleukin-2 Receptor Common Gamma Chain Defect Presented as a Hyper-IgE Syndrome -...

Case Report: Interleukin-2 Receptor Common Gamma Chain Defect Presented as a Hyper-IgE Syndrome  Frontiers

Hugely popular IL-2 Sturmovik devs announce new combat flight sim for next year based on Korean W...

Hugely popular IL-2 Sturmovik devs announce new combat flight sim for next year based on Korean War  ReadWrite

Increased TNF-α/IFN-γ/IL-2 and Decreased TNF-α/IFN-γ Production by Central Memory T Cells Are Ass...

Increased TNF-α/IFN-γ/IL-2 and Decreased TNF-α/IFN-γ Production by Central Memory T Cells Are Associated with Protective Responses against Bovine Tuberculosis Following BCG Vaccination  Frontiers

Lifileucel First Cellular Therapy Approved for Cancer - NCI Cancer Bulletin

Lifileucel First Cellular Therapy Approved for Cancer  NCI Cancer Bulletin

CD8 cis-targeted IL-2 drives potent antiviral activity against hepatitis B virus - Science

CD8 cis-targeted IL-2 drives potent antiviral activity against hepatitis B virus  Science

cells critically depends on the cellular levels of FOXP3 as well as of four transcription factors...

cells critically depends on the cellular levels of FOXP3 as well as of four transcription factors of T cell activation  Frontiers

Measurement of IFN-γ and IL-2 for the assessment of the cellular immunity against SARS-CoV-2 - Na...

Measurement of IFN-γ and IL-2 for the assessment of the cellular immunity against SARS-CoV-2  Nature.com

A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models - JCI

A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models  JCI

A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells (TCR-T cells) against h...

A novel engineered IL-21 receptor arms T-cell receptor-engineered T cells (TCR-T cells) against hepatocellular carcinoma  Nature.com

Low-Zone IL-2 Signaling: Fusion Proteins Containing Linked CD25 and IL-2 Domains Sustain Toleroge...

Low-Zone IL-2 Signaling: Fusion Proteins Containing Linked CD25 and IL-2 Domains Sustain Tolerogenic Vaccination in vivo and Promote Dominance of FOXP3+ Tregs in vitro  Frontiers

The effect of serum IL-2 levels on the prognosis of primary biliary cholangitis-related liver fai...

The effect of serum IL-2 levels on the prognosis of primary biliary cholangitis-related liver failure and the preliminary exploration of its mechanism  Frontiers

A novel interleukin-2-based fusion molecule, HCW9302, differentially promotes regulatory T cell e...

A novel interleukin-2-based fusion molecule, HCW9302, differentially promotes regulatory T cell expansion to treat atherosclerosis in mice  Frontiers

IL-2-Mediated In Vivo Expansion of Regulatory T Cells Combined with CD154–CD40 Co-Stimulation Blo...

IL-2-Mediated In Vivo Expansion of Regulatory T Cells Combined with CD154–CD40 Co-Stimulation Blockade but Not CTLA-4 Ig Prolongs Allograft Survival in Naive and Sensitized Mice  Frontiers

Chicken γδ T cells proliferate upon IL-2 and IL-12 treatment and show a restricted receptor reper...

Chicken γδ T cells proliferate upon IL-2 and IL-12 treatment and show a restricted receptor repertoire in cell culture  Frontiers

Engineering IL-2 for immunotherapy of autoimmunity and cancer - Nature.com

Engineering IL-2 for immunotherapy of autoimmunity and cancer  Nature.com

A Comprehensive Safety Trial of Chimeric Antibody 14.18 With GM-CSF, IL-2, and Isotretinoin in Hi...

A Comprehensive Safety Trial of Chimeric Antibody 14.18 With GM-CSF, IL-2, and Isotretinoin in High-Risk Neuroblastoma Patients Following Myeloablative Therapy: Children’s Oncology Group Study ANBL0931  Frontiers

IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective...

IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein  Science

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothe...

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells  pnas.org

Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with redu...

Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with reduced toxicity  JCI

De novo design of potent and selective mimics of IL-2 and IL-15 - Nature.com

De novo design of potent and selective mimics of IL-2 and IL-15  Nature.com

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes - Sci...

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes  Science

Biology and regulation of IL-2: from molecular mechanisms to human therapy - Nature.com

Biology and regulation of IL-2: from molecular mechanisms to human therapy  Nature.com

A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy -...

A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy  Nature.com

Effects of calcium supplementation on changes in the IL2, IL4, IL6, IL10 axes and oxidative stres...

Effects of calcium supplementation on changes in the IL2, IL4, IL6, IL10 axes and oxidative stress in pregnant women at risk for pre-eclampsia  BMC Pregnancy and Childbirth

IL-2 immunotherapy for targeting regulatory T cells in autoimmunity - Genes & Immunity - Nature.com

IL-2 immunotherapy for targeting regulatory T cells in autoimmunity - Genes & Immunity  Nature.com

Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor ...

Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor  pnas.org

Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and...

Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity  Nature.com