Nektar says IL-2 pathway agonist rejected by Lilly succeeds in atopic dermatitis trial - FirstWor...

Nektar says IL-2 pathway agonist rejected by Lilly succeeds in atopic dermatitis trial  FirstWord Pharma

Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune respons...

Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune response  Nature

Gluten-Stimulated Interleukin-2 Secretion Useful for Diagnosing Celiac Disease - Physician's Weekly

Gluten-Stimulated Interleukin-2 Secretion Useful for Diagnosing Celiac Disease  Physician's Weekly

A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals - ...

A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals  Science | AAAS

Satb1 directs the differentiation of TH17 cells through suppression of IL-2 expression - ScienceD...

Satb1 directs the differentiation of TH17 cells through suppression of IL-2 expression  ScienceDirect.com

Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, dou...

Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial  The Lancet

Mural risks going to the wall as IL-2 flop triggers 90% staff reduction, hunt for strategic alter...

Mural risks going to the wall as IL-2 flop triggers 90% staff reduction, hunt for strategic alternatives  Fierce Biotech

Adding low-dose IL-2 to riluzole may improve survival in ALS - ALS News Today

Adding low-dose IL-2 to riluzole may improve survival in ALS  ALS News Today

Cue Biopharma Receives FDA Feedback on Pre-IND Briefing Document Reinforcing Company’s Intention ...

Cue Biopharma Receives FDA Feedback on Pre-IND Briefing Document Reinforcing Company’s Intention to Advance IND Submission for CUE-401 to Address Unmet Need in the Treatment of Autoimmune Disease  TradingView

The Interleukin-2 Market is Set to Reach USD 4 Billion by 2034, Driven by IL-2 Targeting Fusion P...

The Interleukin-2 Market is Set to Reach USD 4 Billion by 2034, Driven by IL-2 Targeting Fusion Proteins, Monoclonal antibodies, and Gene Therapies Across Immunology, Dermatology, Neurodegenerative Disorders, and Oncology | DelveInsight  PR Newswire

TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8 - Nature

TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8  Nature

An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to...

An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to promote T cell anergy  ScienceDirect.com

Coordinating interleukin-2 encoding circRNA with immunomodulatory lipid nanoparticles to potentia...

Coordinating interleukin-2 encoding circRNA with immunomodulatory lipid nanoparticles to potentiate cancer immunotherapy  Science | AAAS

Examining the evidence for IL-2 in amyotrophic lateral sclerosis - The Lancet

Examining the evidence for IL-2 in amyotrophic lateral sclerosis  The Lancet

Low-dose interleukin-2 induces clonal expansion of BACH2-repressed effector regulatory T cells fo...

Low-dose interleukin-2 induces clonal expansion of BACH2-repressed effector regulatory T cells following acute coronary syndrome  Nature

A tetraspecific engager armed with a non-alpha IL-2 variant harnesses natural killer cells agains...

A tetraspecific engager armed with a non-alpha IL-2 variant harnesses natural killer cells against B cell non-Hodgkin lymphoma  Science | AAAS

Biomineral tablets for long-acting IL-2 immunotherapy - Nature

Biomineral tablets for long-acting IL-2 immunotherapy  Nature

CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation | Nature Communic...

CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation | Nature Communications  Nature

An in situ engineered chimeric IL-2 receptor potentiates the tumoricidal activity of proinflammat...

An in situ engineered chimeric IL-2 receptor potentiates the tumoricidal activity of proinflammatory CAR macrophages in renal cell carcinoma  Nature

Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficac...

Expression of an interleukin-2 partial agonist enhances regulatory T cell persistence and efficacy in mouse autoimmune models  Nature

IL-2/anti-IL-2 antibody complexes augment immune responses to therapeutic cancer vaccines - PNAS

IL-2/anti-IL-2 antibody complexes augment immune responses to therapeutic cancer vaccines  PNAS

National Air and Space Museum Completes Restoration of Ilyushin Il-2 Shturmovik - Vintage Aviatio...

National Air and Space Museum Completes Restoration of Ilyushin Il-2 Shturmovik  Vintage Aviation News

Human serum albumin promotes interactions between HSA-IL-2 fusion protein and CD122 for enhancing...

Human serum albumin promotes interactions between HSA-IL-2 fusion protein and CD122 for enhancing immunotherapy  ScienceDirect.com

Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 ove...

Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer  Nature

Spatial microniches of IL-2 combine with IL-10 to drive lung migratory T - Nature

Spatial microniches of IL-2 combine with IL-10 to drive lung migratory T  Nature

Harnessing IL-2 for immunotherapy against cancer and chronic infection: a historical perspective ...

Harnessing IL-2 for immunotherapy against cancer and chronic infection: a historical perspective and emerging trends  Nature

Novel [18F]FPG-interleukin-2 conjugate for monitoring immune checkpoint therapy with positron emi...

Novel [18F]FPG-interleukin-2 conjugate for monitoring immune checkpoint therapy with positron emission tomography  ScienceDirect.com

A glimpse into the application of the immunomodulatory effect of IL-2 in systemic lupus erythemat...

A glimpse into the application of the immunomodulatory effect of IL-2 in systemic lupus erythematosus  Frontiers

Scientists Identify Key Biomarkers That May Predict Low-Dose IL-2 Treatment Efficacy in People wi...

Scientists Identify Key Biomarkers That May Predict Low-Dose IL-2 Treatment Efficacy in People with Systemic Lupus Erythematosus  Lupus Foundation of America

T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics - ...

T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics  Nature

Based on the immune system: the role of the IL-2 family in pancreatic disease - Frontiers

Based on the immune system: the role of the IL-2 family in pancreatic disease  Frontiers

WW2 Flight Sim Il-2 Sturmovik Announces Final Expansion Before New Korea Game - DualShockers

WW2 Flight Sim Il-2 Sturmovik Announces Final Expansion Before New Korea Game  DualShockers

Claude on Google Cloud’s Vertex AI: FedRAMP High and IL2 Authorized - Anthropic

Claude on Google Cloud’s Vertex AI: FedRAMP High and IL2 Authorized  Anthropic

Targeting systemic IL-2 to BCMA CAR-T cells - Nature

Targeting systemic IL-2 to BCMA CAR-T cells  Nature

Early Serum IL-2 Levels Are Associated With CAR T-Cell Expansion Post–CAR T-Cell Therapy - OncLive

Early Serum IL-2 Levels Are Associated With CAR T-Cell Expansion Post–CAR T-Cell Therapy  OncLive

Aulos Bioscience to Present Promising Phase 2 Data for Novel IL-2 Therapeutic AU-007 in Melanoma ...

Aulos Bioscience to Present Promising Phase 2 Data for Novel IL-2 Therapeutic AU-007 in Melanoma at AACR Annual Meeting  BioSpace

IL-2 and IL-15 Augment HBV Therapeutic Vaccination and PD1 Blockade for Functional Cure In the AA...

IL-2 and IL-15 Augment HBV Therapeutic Vaccination and PD1 Blockade for Functional Cure In the AAV-HBV Mouse Model  Frontiers

The regulatory T cell-selective interleukin-2 receptor agonist rezpegaldesleukin in the treatment...

The regulatory T cell-selective interleukin-2 receptor agonist rezpegaldesleukin in the treatment of inflammatory skin diseases: two randomized, double-blind, placebo-controlled phase 1b trials  Nature

Coya touts partnership potential as IL-2 prospect comes through small Alzheimer's study - Fierce ...

Coya touts partnership potential as IL-2 prospect comes through small Alzheimer's study  Fierce Biotech

Teva's Breakthrough Cancer Immunotherapy Gains Momentum with Major Asian Market Partnership - Sto...

Teva's Breakthrough Cancer Immunotherapy Gains Momentum with Major Asian Market Partnership  Stock Titan

Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T ...

Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation  Nature

IL-2 based cancer immunotherapies: an evolving paradigm - Frontiers

IL-2 based cancer immunotherapies: an evolving paradigm  Frontiers

Development at Rockford’s US-20 and IL-2 interchange could soon bring 37,000 jobs - MyStateline

Development at Rockford’s US-20 and IL-2 interchange could soon bring 37,000 jobs  MyStateline

IL-2 Sturmovik Flying Circus Vol. IV Released - FSElite

IL-2 Sturmovik Flying Circus Vol. IV Released  FSElite

Low-dose IL-2 promising in bullous pemphigoid treatment - Healio

Low-dose IL-2 promising in bullous pemphigoid treatment  Healio

BCANTT 2024: Rationally Engineered IL2 for Enhanced Treatment of Local and Metastatic Bladder Can...

BCANTT 2024: Rationally Engineered IL2 for Enhanced Treatment of Local and Metastatic Bladder Cancer  UroToday

Novel design of potent anti-tumour activity of IL-2 prodrug by FAPα-mediated activation - Science...

Novel design of potent anti-tumour activity of IL-2 prodrug by FAPα-mediated activation  ScienceDirect.com

Engineered IL-2 molecule shows promise in treating autoimmune disease - McGill University

Engineered IL-2 molecule shows promise in treating autoimmune disease  McGill University

Dr Tarhini on the Combination of High-Dose Bolus IL-2 and CTLA-4 Inhibition in Advanced Melanoma ...

Dr Tarhini on the Combination of High-Dose Bolus IL-2 and CTLA-4 Inhibition in Advanced Melanoma  OncLive

Fig. 4. IL-2-induced T cell proliferation in the presence of high-dose... - researchgate.net

Fig. 4. IL-2-induced T cell proliferation in the presence of high-dose...  researchgate.net

Fig. 2. 4H3MC inhibits IL-2 production in activated T cells. (A) Jurkat... - researchgate.net

Fig. 2. 4H3MC inhibits IL-2 production in activated T cells. (A) Jurkat...  researchgate.net

IL-2 Receptor-Targeted Therapy Approved for Relapsed/Refractory CTCL - MedPage Today

IL-2 Receptor-Targeted Therapy Approved for Relapsed/Refractory CTCL  MedPage Today

A Comprehensive Review of Low-Dose Interleukin-2 (IL-2) Therapy for Systemic Lupus Erythematosus:...

A Comprehensive Review of Low-Dose Interleukin-2 (IL-2) Therapy for Systemic Lupus Erythematosus: Mechanisms, Efficacy, and Clinical Applications  Cureus

Fig. 1. Interleukin-2 takes center stage. The different functional... - researchgate.net

Fig. 1. Interleukin-2 takes center stage. The different functional...  researchgate.net

Central control of dynamic gene circuits governs T cell rest and activation - Nature

Central control of dynamic gene circuits governs T cell rest and activation  Nature

Figure 5. Interleukin-2 (IL-2) activity in blood mononuclear cell... - researchgate.net

Figure 5. Interleukin-2 (IL-2) activity in blood mononuclear cell...  researchgate.net

10-Day Weather Forecast for Chicago, IL - The Weather Channel | weather.com - The Weather Channel

10-Day Weather Forecast for Chicago, IL - The Weather Channel | weather.com  The Weather Channel

IL-2 Korea Announcement - FSElite

IL-2 Korea Announcement  FSElite

The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity ...

The IL-2 Defect in Systemic Lupus Erythematosus Disease Has an Expansive Effect on Host Immunity  Wiley Online Library

A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models - JC...

A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models  JCI.org

PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function - Nature

PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function  Nature

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program - Nature

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program  Nature

IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective...

IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein  Science | AAAS

Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with redu...

Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with reduced toxicity  JCI.org

Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor ...

Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor  PNAS

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothe...

Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells  PNAS

An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity...

An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice  Science | AAAS

Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and...

Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity | Signal Transduction and Targeted Therapy  Nature

A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy -...

A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy  Nature

Engineering IL-2 for immunotherapy of autoimmunity and cancer - Nature

Engineering IL-2 for immunotherapy of autoimmunity and cancer  Nature

IL-2 treatment can be dangerous. Here’s how drug firms are trying to fix it - C&EN

IL-2 treatment can be dangerous. Here’s how drug firms are trying to fix it  C&EN

FIGURE 3. IL-2 and IL-12 induce IFN-g production by NK cells in vitro.... - researchgate.net

FIGURE 3. IL-2 and IL-12 induce IFN-g production by NK cells in vitro....  researchgate.net

Emerging mechanisms and applications of low-dose IL-2 therapy in autoimmunity - ScienceDirect.com

Emerging mechanisms and applications of low-dose IL-2 therapy in autoimmunity  ScienceDirect.com

IL-2 immunotherapy for targeting regulatory T cells in autoimmunity - Genes & Immunity - Nature

IL-2 immunotherapy for targeting regulatory T cells in autoimmunity - Genes & Immunity  Nature

Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung...

Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung allograft acceptance in mice  Nature

IL-2-free tumor-infiltrating lymphocyte therapy with PD-1 blockade demonstrates potent efficacy i...

IL-2-free tumor-infiltrating lymphocyte therapy with PD-1 blockade demonstrates potent efficacy in advanced gynecologic cancer  BMC Medicine

An engineered IL-2 partial agonist promotes CD8+ T cell stemness - Nature

An engineered IL-2 partial agonist promotes CD8+ T cell stemness  Nature

De novo design of potent and selective mimics of IL-2 and IL-15 - Nature

De novo design of potent and selective mimics of IL-2 and IL-15  Nature

IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function - Sci...

IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function  ScienceDirect.com

Competition for IL-2 between Regulatory and Effector T Cells to Chisel Immune Responses - Frontiers

Competition for IL-2 between Regulatory and Effector T Cells to Chisel Immune Responses  Frontiers

An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism - Nature

An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism  Nature

Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells - Nature

Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells  Nature

Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist...

Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist  Nature

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes - Sci...

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes  Science | AAAS

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulator...

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation  Nature

Lifileucel Induces Response in Metastatic Melanoma Independent of Number of IL-2 Doses Received -...

Lifileucel Induces Response in Metastatic Melanoma Independent of Number of IL-2 Doses Received  OncLive

A single-agent fusion of human IL-2 and anti-IL-2 antibody that selectively expands regulatory T ...

A single-agent fusion of human IL-2 and anti-IL-2 antibody that selectively expands regulatory T cells  Nature

Dr Olson on Toxicities Associated With Lifileucel and IL-2 in Melanoma - OncLive

Dr Olson on Toxicities Associated With Lifileucel and IL-2 in Melanoma  OncLive

Defining the Threshold IL-2 Signal Required for Induction of Selective Treg Cell Responses Using ...

Defining the Threshold IL-2 Signal Required for Induction of Selective Treg Cell Responses Using Engineered IL-2 Muteins  Frontiers

Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney tra...

Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney transplant recipients  Nature

Interleukin (IL)-2 Is a Key Regulator of T Helper 1 and T Helper 2 Cytokine Expression in Fish: F...

Interleukin (IL)-2 Is a Key Regulator of T Helper 1 and T Helper 2 Cytokine Expression in Fish: Functional Characterization of Two Divergent IL2 Paralogs in Salmonids  Frontiers

Engineered E. coli Nissle 1917 for delivery of bioactive IL-2 for cancer immunotherapy - Nature

Engineered E. coli Nissle 1917 for delivery of bioactive IL-2 for cancer immunotherapy  Nature

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helpe...

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells  Science | AAAS

Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulatio...

Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity  Nature

Autocrine and paracrine IL-2 signals collaborate to regulate distinct phases of CD8 T cell memory...

Autocrine and paracrine IL-2 signals collaborate to regulate distinct phases of CD8 T cell memory  ScienceDirect.com

Differential Roles of IL-2 Signaling in Developing versus Mature Tregs - ScienceDirect.com

Differential Roles of IL-2 Signaling in Developing versus Mature Tregs  ScienceDirect.com

Molecular reshaping of phage-displayed Interleukin-2 at beta chain receptor interface to obtain p...

Molecular reshaping of phage-displayed Interleukin-2 at beta chain receptor interface to obtain potent super-agonists with improved developability profiles | Communications Biology  Nature

Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue...

Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue  Nature

An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer - Nature

An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer  Nature

Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-TFH cells - Scienc...

Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-TFH cells  Science | AAAS