"il2" の関連情報検索結果

Therapeutic activity of F8-IL2 immunocytokine in combination with... - researchgate.net



Therapeutic activity of F8-IL2 immunocytokine in combination with...  researchgate.net

TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion | Nature Com...



TIM3-blockade synergizes with IL2 in alleviating intra-tumoral CD8+T cell exhaustion | Nature Communications  Nature

A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-media...



A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies  ScienceDirect.com

A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals - ...



A distinct priming phase regulates CD8 T cell immunity by orchestrating paracrine IL-2 signals  Science | AAAS

Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, dou...



Efficacy and safety of low-dose IL-2 as an add-on therapy to riluzole (MIROCALS): a phase 2b, double-blind, randomised, placebo-controlled trial  The Lancet

Nektar says IL-2 pathway agonist rejected by Lilly succeeds in atopic dermatitis trial - FirstWor...



Nektar says IL-2 pathway agonist rejected by Lilly succeeds in atopic dermatitis trial  FirstWord Pharma

Claude on Google Cloud’s Vertex AI: FedRAMP High and IL2 Authorized - Anthropic



Claude on Google Cloud’s Vertex AI: FedRAMP High and IL2 Authorized  Anthropic

Abstract 4144964: Low-Dose IL-2 Lowers Arterial Inflammation and Trends Towards Lower MACE in pat...



Abstract 4144964: Low-Dose IL-2 Lowers Arterial Inflammation and Trends Towards Lower MACE in patients with ACS: The results of the IVORY trial and IVORY FINALE study  American Heart Association Journals

AWT020: a novel fusion protein harnessing PD-1 blockade and selective IL-2 Cis-activation for enh...



AWT020: a novel fusion protein harnessing PD-1 blockade and selective IL-2 Cis-activation for enhanced anti-tumor immunity and diminished toxicity  Frontiers

Mural risks going to the wall as IL-2 flop triggers 90% staff reduction, hunt for strategic alter...



Mural risks going to the wall as IL-2 flop triggers 90% staff reduction, hunt for strategic alternatives  Fierce Biotech

Directed disruption of IL2 aggregation and receptor binding sites produces designer biologics wit...



Directed disruption of IL2 aggregation and receptor binding sites produces designer biologics with enhanced specificity and improved production capacity  ScienceDirect.com

CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation | Nature Communic...



CD301b+ dendritic cell-derived IL-2 dictates CD4+ T helper cell differentiation | Nature Communications  Nature

Examining the evidence for IL-2 in amyotrophic lateral sclerosis - The Lancet



Examining the evidence for IL-2 in amyotrophic lateral sclerosis  The Lancet

In-situ trichosanthin-IL2/pectin dynamic hydrogel activates dendritic cells and reverses T cell e...



In-situ trichosanthin-IL2/pectin dynamic hydrogel activates dendritic cells and reverses T cell exhaustion for post-operative cancer therapy  ScienceDirect.com

An in situ engineered chimeric IL-2 receptor potentiates the tumoricidal activity of proinflammat...



An in situ engineered chimeric IL-2 receptor potentiates the tumoricidal activity of proinflammatory CAR macrophages in renal cell carcinoma  Nature

An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to...



An IL-2 mutein increases regulatory T cell suppression of dendritic cells via IL-10 and CTLA-4 to promote T cell anergy  ScienceDirect.com

Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune respons...



Long-acting IL-2 release from pressure-fused biomineral tablets promotes antitumor immune response  Nature

Harnessing IL-2 for immunotherapy against cancer and chronic infection: a historical perspective ...



Harnessing IL-2 for immunotherapy against cancer and chronic infection: a historical perspective and emerging trends  Nature

Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 ove...



Tebentafusp, a T cell engager, promotes macrophage reprogramming and in combination with IL-2 overcomes macrophage immunosuppression in cancer  Nature

Biomineral tablets for long-acting IL-2 immunotherapy - Nature



Biomineral tablets for long-acting IL-2 immunotherapy  Nature

A tetraspecific engager armed with a non-alpha IL-2 variant harnesses natural killer cells agains...



A tetraspecific engager armed with a non-alpha IL-2 variant harnesses natural killer cells against B cell non-Hodgkin lymphoma  Science | AAAS

Spatial microniches of IL-2 combine with IL-10 to drive lung migratory T - Nature



Spatial microniches of IL-2 combine with IL-10 to drive lung migratory T  Nature

Novel [18F]FPG-interleukin-2 conjugate for monitoring immune checkpoint therapy with positron emi...



Novel [18F]FPG-interleukin-2 conjugate for monitoring immune checkpoint therapy with positron emission tomography  ScienceDirect.com

Targeting systemic IL-2 to BCMA CAR-T cells - Nature



Targeting systemic IL-2 to BCMA CAR-T cells  Nature

Early Serum IL-2 Levels Are Associated With CAR T-Cell Expansion Post–CAR T-Cell Therapy - OncLive



Early Serum IL-2 Levels Are Associated With CAR T-Cell Expansion Post–CAR T-Cell Therapy  OncLive

Adding low-dose IL-2 to riluzole may improve survival in ALS - ALS News Today



Adding low-dose IL-2 to riluzole may improve survival in ALS  ALS News Today

WW2 Flight Sim Il-2 Sturmovik Announces Final Expansion Before New Korea Game - DualShockers



WW2 Flight Sim Il-2 Sturmovik Announces Final Expansion Before New Korea Game  DualShockers

Scientists Identify Key Biomarkers That May Predict Low-Dose IL-2 Treatment Efficacy in People wi...



Scientists Identify Key Biomarkers That May Predict Low-Dose IL-2 Treatment Efficacy in People with Systemic Lupus Erythematosus  Lupus Foundation of America

BCANTT 2024: Rationally Engineered IL2 for Enhanced Treatment of Local and Metastatic Bladder Can...



BCANTT 2024: Rationally Engineered IL2 for Enhanced Treatment of Local and Metastatic Bladder Cancer  UroToday

Human serum albumin promotes interactions between HSA-IL-2 fusion protein and CD122 for enhancing...



Human serum albumin promotes interactions between HSA-IL-2 fusion protein and CD122 for enhancing immunotherapy  ScienceDirect.com

Teva's Breakthrough Cancer Immunotherapy Gains Momentum with Major Asian Market Partnership - Sto...



Teva's Breakthrough Cancer Immunotherapy Gains Momentum with Major Asian Market Partnership  Stock Titan

IL-2/anti-IL-2 antibody complexes augment immune responses to therapeutic cancer vaccines - PNAS



IL-2/anti-IL-2 antibody complexes augment immune responses to therapeutic cancer vaccines  PNAS

Regulating IL-2 Immune Signaling Function Via A Core Allosteric Structural Network - ScienceDirec...



Regulating IL-2 Immune Signaling Function Via A Core Allosteric Structural Network  ScienceDirect.com

IL-2 immunotherapy rescues irradiation-induced T cell exhaustion in mouse colon cancer - ScienceD...



IL-2 immunotherapy rescues irradiation-induced T cell exhaustion in mouse colon cancer  ScienceDirect.com

IL-2 Sturmovik Flying Circus Vol. IV Released - FSElite



IL-2 Sturmovik Flying Circus Vol. IV Released  FSElite

Based on the immune system: the role of the IL-2 family in pancreatic disease - Frontiers



Based on the immune system: the role of the IL-2 family in pancreatic disease  Frontiers

IL-2 Complexed With Anti–IL-2 Antibody Expands the Maternal T-Regulatory Cell Pool and Alleviates...



IL-2 Complexed With Anti–IL-2 Antibody Expands the Maternal T-Regulatory Cell Pool and Alleviates Fetal Loss in Abortion-Prone Mice  ScienceDirect.com

Novel engineered IL-2 Nemvaleukin alfa combined with PD1 checkpoint blockade enhances the systemi...



Novel engineered IL-2 Nemvaleukin alfa combined with PD1 checkpoint blockade enhances the systemic anti-tumor responses of radiation therapy  Journal of Experimental & Clinical Cancer Research

T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics - ...



T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics  Nature

Worst Piloting Fails and Mishaps IL2 Sturmovik BoS - MSN



Worst Piloting Fails and Mishaps IL2 Sturmovik BoS  MSN

Engineered IL-2 molecule shows promise in treating autoimmune disease - McGill University



Engineered IL-2 molecule shows promise in treating autoimmune disease  McGill University

Development at Rockford’s US-20 and IL-2 interchange could soon bring 37,000 jobs - MyStateline



Development at Rockford’s US-20 and IL-2 interchange could soon bring 37,000 jobs  MyStateline

Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T ...



Tyrosine phosphorylation of both STAT5A and STAT5B is necessary for maximal IL-2 signaling and T cell proliferation  Nature

Novel design of potent anti-tumour activity of IL-2 prodrug by FAPα-mediated activation - Science...



Novel design of potent anti-tumour activity of IL-2 prodrug by FAPα-mediated activation  ScienceDirect.com

IL-2 based cancer immunotherapies: an evolving paradigm - Frontiers



IL-2 based cancer immunotherapies: an evolving paradigm  Frontiers

Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strateg...



Reigniting hope in cancer treatment: the promise and pitfalls of IL-2 and IL-2R targeting strategies  Molecular Cancer

A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models - JC...



A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models  JCI - Welcome

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program - Nature



PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program  Nature

A cytokine receptor-masked IL2 prodrug selectively activates tumor-infiltrating lymphocytes for p...



A cytokine receptor-masked IL2 prodrug selectively activates tumor-infiltrating lymphocytes for potent antitumor therapy  Nature

Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor ...



Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor  PNAS

The scFv-IL2 fusion protein maintains the functions of both component proteins. - researchgate.net



The scFv-IL2 fusion protein maintains the functions of both component proteins.  researchgate.net

A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy -...



A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy  Nature

Localization of Salmonella and albumin-IL-2 to the tumor microenvironment augments anticancer T c...



Localization of Salmonella and albumin-IL-2 to the tumor microenvironment augments anticancer T cell immunity  Journal of Biomedical Science

PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function - Nature



PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function  Nature

IL-2 immunotherapy for targeting regulatory T cells in autoimmunity - Genes & Immunity - Nature



IL-2 immunotherapy for targeting regulatory T cells in autoimmunity - Genes & Immunity  Nature

Emerging mechanisms and applications of low-dose IL-2 therapy in autoimmunity - ScienceDirect.com



Emerging mechanisms and applications of low-dose IL-2 therapy in autoimmunity  ScienceDirect.com

IL-2 treatment can be dangerous. Here’s how drug firms are trying to fix it - C&EN



IL-2 treatment can be dangerous. Here’s how drug firms are trying to fix it  C&EN

Exogenous IL-2 delays memory precursors generation and is essential for enhancing memory cells ef...



Exogenous IL-2 delays memory precursors generation and is essential for enhancing memory cells effector functions  ScienceDirect.com

Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2...



Molecular and cognitive signatures of ageing partially restored through synthetic delivery of IL2 to the brain  EMBO Press

An engineered IL-2 partial agonist promotes CD8+ T cell stemness - Nature



An engineered IL-2 partial agonist promotes CD8+ T cell stemness  Nature

De novo design of potent and selective mimics of IL-2 and IL-15 - Nature



De novo design of potent and selective mimics of IL-2 and IL-15  Nature

Acidity suppresses CD8 + T-cell function by perturbing IL-2, mTORC1, and c-Myc signaling - EMBO P...



Acidity suppresses CD8 + T-cell function by perturbing IL-2, mTORC1, and c-Myc signaling  EMBO Press

IL-2 family cytokines IL-9 and IL-21 differentially regulate innate and adaptive type 2 immunity ...



IL-2 family cytokines IL-9 and IL-21 differentially regulate innate and adaptive type 2 immunity in asthma  ScienceDirect.com

Engineered E. coli Nissle 1917 for delivery of bioactive IL-2 for cancer immunotherapy - Nature



Engineered E. coli Nissle 1917 for delivery of bioactive IL-2 for cancer immunotherapy  Nature

Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and...



Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity | Signal Transduction and Targeted Therapy  Nature

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes - Sci...



Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes  Science | AAAS

T cell exhaustion by activating the aryl hydrocarbon receptor - Nature



T cell exhaustion by activating the aryl hydrocarbon receptor  Nature

An essential role for the IL-2 receptor in T - Nature



An essential role for the IL-2 receptor in T  Nature

IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function - Sci...



IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function  ScienceDirect.com

Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulatio...



Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity  Nature

The antitumor effect induced by an IL-2 ‘no-alpha’ mutein depends on changes in the CD8 - Frontiers



The antitumor effect induced by an IL-2 ‘no-alpha’ mutein depends on changes in the CD8  Frontiers

A single-agent fusion of human IL-2 and anti-IL-2 antibody that selectively expands regulatory T ...



A single-agent fusion of human IL-2 and anti-IL-2 antibody that selectively expands regulatory T cells  Nature

Biology and regulation of IL-2: from molecular mechanisms to human therapy - Nature



Biology and regulation of IL-2: from molecular mechanisms to human therapy  Nature

Genetically modified IL2 bone-marrow-derived myeloid cells reprogram the glioma immunosuppressive...



Genetically modified IL2 bone-marrow-derived myeloid cells reprogram the glioma immunosuppressive tumor microenvironment  ScienceDirect.com

A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8 - Nature



A next-generation tumor-targeting IL-2 preferentially promotes tumor-infiltrating CD8  Nature

Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist...



Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist  Nature

A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo ...



A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells  Nature

Measurement of IFN-γ and IL-2 for the assessment of the cellular immunity against SARS-CoV-2 - Na...



Measurement of IFN-γ and IL-2 for the assessment of the cellular immunity against SARS-CoV-2  Nature

Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with redu...



Selective delivery of low-affinity IL-2 to PD-1+ T cells rejuvenates antitumor immunity with reduced toxicity  JCI - Welcome

IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8 - Nature



IL-2 delivery by engineered mesenchymal stem cells re-invigorates CD8  Nature

T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes - Nature



T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes  Nature

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helpe...



Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells  Science | AAAS

Engineering IL-2 for immunotherapy of autoimmunity and cancer - Nature



Engineering IL-2 for immunotherapy of autoimmunity and cancer  Nature

Defining the Threshold IL-2 Signal Required for Induction of Selective Treg Cell Responses Using ...



Defining the Threshold IL-2 Signal Required for Induction of Selective Treg Cell Responses Using Engineered IL-2 Muteins  Frontiers

Low-Dose IL-2 Therapy in Autoimmune and Rheumatic Diseases - Frontiers



Low-Dose IL-2 Therapy in Autoimmune and Rheumatic Diseases  Frontiers

Membrane-bound IL-2 improves the expansion, survival, and phenotype of CAR Tregs and confers resi...



Membrane-bound IL-2 improves the expansion, survival, and phenotype of CAR Tregs and confers resistance to calcineurin inhibitors  Frontiers

Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung...



Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung allograft acceptance in mice  Nature

A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism - N...



A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism  Nature

Lifileucel Induces Response in Metastatic Melanoma Independent of Number of IL-2 Doses Received -...



Lifileucel Induces Response in Metastatic Melanoma Independent of Number of IL-2 Doses Received  OncLive

Salmonella-IL2 May Improve Upon FOLFIRINOX in Stage IV Pancreatic Cancer - Cancer Therapy Advisor



Salmonella-IL2 May Improve Upon FOLFIRINOX in Stage IV Pancreatic Cancer  Cancer Therapy Advisor

An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism - Nature



An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism  Nature

Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells - Nature



Low-dose IL-2 enhances the generation of IL-10-producing immunoregulatory B cells  Nature

Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2—A Balancing Act - Frontiers



Regulation of Effector and Memory CD8 T Cell Differentiation by IL-2—A Balancing Act  Frontiers

IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repress...



IL-2 imprints human naive B cell fate towards plasma cell through ERK/ELK1-mediated BACH2 repression  Nature

IL2 Sturmovik guide: how to play IL2 Battle of Stalingrad - wargamer.com



IL2 Sturmovik guide: how to play IL2 Battle of Stalingrad  wargamer.com

Dr Olson on Toxicities Associated With Lifileucel and IL-2 in Melanoma - OncLive



Dr Olson on Toxicities Associated With Lifileucel and IL-2 in Melanoma  OncLive

cAMP response element modulator α controls IL2 and IL17A expression during CD4 lineage commitment...



cAMP response element modulator α controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus  PNAS

A novel human IL-2 mutein with minimal systemic toxicity exerts greater antitumor efficacy than w...



A novel human IL-2 mutein with minimal systemic toxicity exerts greater antitumor efficacy than wild-type IL-2  Nature

A DNA vaccine (EG95-PT1/2/3-IL2) encoding multi-epitope antigen and IL-2 provokes efficient and l...



A DNA vaccine (EG95-PT1/2/3-IL2) encoding multi-epitope antigen and IL-2 provokes efficient and long-term immunity to echinococcosis  ScienceDirect.com

Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a...



Selective activation and expansion of regulatory T cells using lipid encapsulated mRNA encoding a long-acting IL-2 mutein  Nature